FIGNL2 (fidgetin like 2)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 401720
• Gene name: Fidgetin like 2
• Gene symbol: FIGNL2
• Synonyms (NCBI Gene): -
• Chromosome: 12
• Chromosome location: 12q13.13

miRNA Show/Hide all (148)

miRTarBase ID	miRNA	Experiments	Reference
MIRT996814	hsa-let-7a	CLIP-seq
MIRT996815	hsa-let-7b	CLIP-seq
MIRT996816	hsa-let-7c	CLIP-seq
MIRT996817	hsa-let-7d	CLIP-seq
MIRT996818	hsa-let-7e	CLIP-seq
MIRT996819	hsa-let-7f	CLIP-seq
MIRT996820	hsa-let-7g	CLIP-seq
MIRT996821	hsa-let-7i	CLIP-seq
MIRT996822	hsa-miR-1207-5p	CLIP-seq
MIRT996823	hsa-miR-1236	CLIP-seq
MIRT996824	hsa-miR-1262	CLIP-seq
MIRT996825	hsa-miR-1293	CLIP-seq
MIRT996826	hsa-miR-1324	CLIP-seq
MIRT996827	hsa-miR-15a	CLIP-seq
MIRT996828	hsa-miR-15b	CLIP-seq
MIRT996829	hsa-miR-16	CLIP-seq
MIRT996830	hsa-miR-1909	CLIP-seq
MIRT996831	hsa-miR-195	CLIP-seq
MIRT996832	hsa-miR-202	CLIP-seq
MIRT996833	hsa-miR-214	CLIP-seq
MIRT996834	hsa-miR-223	CLIP-seq
MIRT996835	hsa-miR-224	CLIP-seq
MIRT996836	hsa-miR-2467-3p	CLIP-seq
MIRT996837	hsa-miR-3125	CLIP-seq
MIRT996838	hsa-miR-3144-5p	CLIP-seq
MIRT996839	hsa-miR-3150a-3p	CLIP-seq
MIRT996840	hsa-miR-3151	CLIP-seq
MIRT996841	hsa-miR-3158-5p	CLIP-seq
MIRT996842	hsa-miR-3175	CLIP-seq
MIRT996843	hsa-miR-3182	CLIP-seq
MIRT996844	hsa-miR-3191	CLIP-seq
MIRT996845	hsa-miR-338-3p	CLIP-seq
MIRT996846	hsa-miR-3529	CLIP-seq
MIRT996847	hsa-miR-361-3p	CLIP-seq
MIRT996848	hsa-miR-3619-5p	CLIP-seq
MIRT996849	hsa-miR-3649	CLIP-seq
MIRT996850	hsa-miR-3678-3p	CLIP-seq
MIRT996851	hsa-miR-3714	CLIP-seq
MIRT996852	hsa-miR-379	CLIP-seq
MIRT996853	hsa-miR-3916	CLIP-seq
MIRT996854	hsa-miR-3927	CLIP-seq
MIRT996855	hsa-miR-424	CLIP-seq
MIRT996856	hsa-miR-4303	CLIP-seq
MIRT996857	hsa-miR-4310	CLIP-seq
MIRT996858	hsa-miR-4328	CLIP-seq
MIRT996859	hsa-miR-4418	CLIP-seq
MIRT996860	hsa-miR-4458	CLIP-seq
MIRT996861	hsa-miR-4459	CLIP-seq
MIRT996862	hsa-miR-4480	CLIP-seq
MIRT996863	hsa-miR-4483	CLIP-seq
MIRT996864	hsa-miR-4500	CLIP-seq
MIRT996865	hsa-miR-4633-5p	CLIP-seq
MIRT996866	hsa-miR-4649-3p	CLIP-seq
MIRT996867	hsa-miR-4651	CLIP-seq
MIRT996868	hsa-miR-4652-5p	CLIP-seq
MIRT996869	hsa-miR-4659a-3p	CLIP-seq
MIRT996870	hsa-miR-4659b-3p	CLIP-seq
MIRT996871	hsa-miR-4667-5p	CLIP-seq
MIRT996872	hsa-miR-4695-5p	CLIP-seq
MIRT996873	hsa-miR-4700-5p	CLIP-seq
MIRT996874	hsa-miR-4701-3p	CLIP-seq
MIRT996875	hsa-miR-4722-5p	CLIP-seq
MIRT996876	hsa-miR-4727-5p	CLIP-seq
MIRT996877	hsa-miR-4742-5p	CLIP-seq
MIRT996878	hsa-miR-4753-5p	CLIP-seq
MIRT996879	hsa-miR-4762-3p	CLIP-seq
MIRT996880	hsa-miR-4763-3p	CLIP-seq
MIRT996881	hsa-miR-4768-3p	CLIP-seq
MIRT996882	hsa-miR-4769-3p	CLIP-seq
MIRT996883	hsa-miR-486-3p	CLIP-seq
MIRT996884	hsa-miR-491-5p	CLIP-seq
MIRT996885	hsa-miR-497	CLIP-seq
MIRT996886	hsa-miR-509-3-5p	CLIP-seq
MIRT996887	hsa-miR-509-5p	CLIP-seq
MIRT996888	hsa-miR-532-5p	CLIP-seq
MIRT996889	hsa-miR-608	CLIP-seq
MIRT996890	hsa-miR-761	CLIP-seq
MIRT996891	hsa-miR-939	CLIP-seq
MIRT996892	hsa-miR-940	CLIP-seq
MIRT996893	hsa-miR-98	CLIP-seq
MIRT1995588	hsa-miR-184	CLIP-seq
MIRT1995589	hsa-miR-185	CLIP-seq
MIRT1995590	hsa-miR-1908	CLIP-seq
MIRT1995591	hsa-miR-193a-5p	CLIP-seq
MIRT996834	hsa-miR-223	CLIP-seq
MIRT1995592	hsa-miR-2278	CLIP-seq
MIRT1995593	hsa-miR-3143	CLIP-seq
MIRT996844	hsa-miR-3191	CLIP-seq
MIRT1995594	hsa-miR-326	CLIP-seq
MIRT1995595	hsa-miR-330-5p	CLIP-seq
MIRT1995596	hsa-miR-331-3p	CLIP-seq
MIRT996845	hsa-miR-338-3p	CLIP-seq
MIRT1995597	hsa-miR-3918	CLIP-seq
MIRT1995598	hsa-miR-3960	CLIP-seq
MIRT996856	hsa-miR-4303	CLIP-seq
MIRT1995599	hsa-miR-4306	CLIP-seq
MIRT996858	hsa-miR-4328	CLIP-seq
MIRT1995600	hsa-miR-4447	CLIP-seq
MIRT1995601	hsa-miR-4467	CLIP-seq
MIRT1995602	hsa-miR-4472	CLIP-seq
MIRT1995603	hsa-miR-4640-5p	CLIP-seq
MIRT1995604	hsa-miR-4644	CLIP-seq
MIRT996866	hsa-miR-4649-3p	CLIP-seq
MIRT996867	hsa-miR-4651	CLIP-seq
MIRT996869	hsa-miR-4659a-3p	CLIP-seq
MIRT996870	hsa-miR-4659b-3p	CLIP-seq
MIRT1995605	hsa-miR-4706	CLIP-seq
MIRT1995606	hsa-miR-4726-5p	CLIP-seq
MIRT1995607	hsa-miR-4749-5p	CLIP-seq
MIRT1995608	hsa-miR-4757-5p	CLIP-seq
MIRT996879	hsa-miR-4762-3p	CLIP-seq
MIRT996881	hsa-miR-4768-3p	CLIP-seq
MIRT1995609	hsa-miR-543	CLIP-seq
MIRT996889	hsa-miR-608	CLIP-seq
MIRT1995610	hsa-miR-658	CLIP-seq
MIRT1995611	hsa-miR-663	CLIP-seq
MIRT996892	hsa-miR-940	CLIP-seq
MIRT1995589	hsa-miR-185	CLIP-seq
MIRT1995592	hsa-miR-2278	CLIP-seq
MIRT1995599	hsa-miR-4306	CLIP-seq
MIRT1995604	hsa-miR-4644	CLIP-seq
MIRT996881	hsa-miR-4768-3p	CLIP-seq
MIRT996837	hsa-miR-3125	CLIP-seq
MIRT996853	hsa-miR-3916	CLIP-seq
MIRT2533541	hsa-miR-4287	CLIP-seq
MIRT2533542	hsa-miR-4685-3p	CLIP-seq
MIRT996878	hsa-miR-4753-5p	CLIP-seq
MIRT2533543	hsa-miR-4768-5p	CLIP-seq
MIRT2533544	hsa-miR-942	CLIP-seq
MIRT2680997	hsa-miR-1266	CLIP-seq
MIRT996837	hsa-miR-3125	CLIP-seq
MIRT2680998	hsa-miR-3153	CLIP-seq
MIRT2680999	hsa-miR-320a	CLIP-seq
MIRT2681000	hsa-miR-320b	CLIP-seq
MIRT2681001	hsa-miR-320c	CLIP-seq
MIRT2681002	hsa-miR-320d	CLIP-seq
MIRT2681003	hsa-miR-3910	CLIP-seq
MIRT996853	hsa-miR-3916	CLIP-seq
MIRT2681004	hsa-miR-4270	CLIP-seq
MIRT2533541	hsa-miR-4287	CLIP-seq
MIRT2681005	hsa-miR-4429	CLIP-seq
MIRT2681006	hsa-miR-4441	CLIP-seq
MIRT2681007	hsa-miR-4518	CLIP-seq
MIRT2533542	hsa-miR-4685-3p	CLIP-seq
MIRT996878	hsa-miR-4753-5p	CLIP-seq
MIRT2533543	hsa-miR-4768-5p	CLIP-seq
MIRT2681008	hsa-miR-548an	CLIP-seq
MIRT2533544	hsa-miR-942	CLIP-seq

Gene ontology (GO) Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001763	Process	Morphogenesis of a branching structure	ISS
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005938	Component	Cell cortex	IEA
GO:0008568	Function	Microtubule severing ATPase activity	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0030336	Process	Negative regulation of cell migration	IEA
GO:0030336	Process	Negative regulation of cell migration	IMP	25756798, 36523161
GO:0031252	Component	Cell leading edge	IDA	25756798
GO:0048681	Process	Negative regulation of axon regeneration	IEA
GO:0048681	Process	Negative regulation of axon regeneration	ISS
GO:0051013	Process	Microtubule severing	IBA
GO:0051013	Process	Microtubule severing	IEA
GO:0051013	Process	Microtubule severing	IMP	25756798, 36523161
GO:1903690	Process	Negative regulation of wound healing, spreading of epidermal cells	IEA
GO:1903690	Process	Negative regulation of wound healing, spreading of epidermal cells	ISS

Other IDs

• MIM: 620503
• HGNC: 13287
• e!Ensembl: ENSG00000261308

Protein

• UniProt ID: A6NMB9
• Protein name: Fidgetin-like protein 2 (EC 3.6.4.-)
• Protein function: Microtubule-severing enzyme that negatively regulates cell migration and wound healing (PubMed:25756798, PubMed:36523161). In migrating cells, targets dynamic microtubules (MTs) at the leading edge and severs them, thereby suppressing motility (
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00004	AAA	428 → 557	ATPase family associated with various cellular activities (AAA)	Domain

• Sequence:

  MHWTPEHAQPLNQWPEQHLDVSSTTPSPAHKLELPPGGRQRCHYAWAHDDISALTASNLL
  KRYAEKYSGVLDSPYERPALGGYSDASFLNGAKGDPEPWPGPEPPYPLASLHEGLPGTKS
  GGGGGSGALGGSPVLAGNLPEPLYAGNACGGPSAAPEYAAGYGGGYLAPGYCAQTGAALP
  PPPPAALLQPPPPPGYGPSAPLYNYPAGGYAAQPGYGALPPPPGPPPAPYLTPGLPAPTP
  LPAPAPPTAYGFPTAAPGAESGLSLKRKAADEGPEGRYRKYAYEPAKAPVADGASYPAAD
  NGECRGNGFRAKPPGAAEEASGKYGGGVPLKVLGSPVYGPQLEPFEKFPERAPAPRGGFA
  VPSGETPKGVDPGALELVTSKMVDCGPPVQWADVAGQGALKAALEEELVWPLLRPPAYPG
  SLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRLRGATLAAPGAAEGARLLQAAFAAA
  RCRPPSVLLISELEALLPARDDGAAAGGALQVPLLACLDGGCGAGADGVLVVGTTSRPAA
  LDEATRRRFSLRFYVALPDSPARGQILQRALAQQGCALSERELAALVQGTQGFSGGELGQ
  LCQQAAAGAGLPGLQRPLSYKDLEAALAKVGPRASAKELDSFVEWDKMYGSGH

• Sequence length: 653

Related Genes

No strongly related genes found yet for FIGNL2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to FIGNL2.