FHOD1 (formin homology 2 domain containing 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 29109
• Gene name: Formin homology 2 domain containing 1
• Gene symbol: FHOD1
• Synonyms (NCBI Gene): FHOS
• Chromosome: 16
• Chromosome location: 16q22.1
• Summary: This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the F

miRNA Show/Hide all (65)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006618	rno-miR-200c-3p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	22144583
MIRT006618	rno-miR-200c-3p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	22144583
MIRT006618	rno-miR-200c-3p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	22144583
MIRT049791	hsa-miR-92a-3p	CLASH	23622248
MIRT045468	hsa-miR-149-5p	CLASH	23622248
MIRT038061	hsa-miR-423-5p	CLASH	23622248
MIRT649968	hsa-miR-8485	HITS-CLIP	23824327
MIRT649969	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT649967	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT649966	hsa-miR-603	HITS-CLIP	23824327
MIRT649964	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT649965	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT649963	hsa-miR-3941	HITS-CLIP	23824327
MIRT649968	hsa-miR-8485	HITS-CLIP	23824327
MIRT649969	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT649967	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT649966	hsa-miR-603	HITS-CLIP	23824327
MIRT649964	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT649965	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT649963	hsa-miR-3941	HITS-CLIP	23824327
MIRT996595	hsa-miR-1976	CLIP-seq
MIRT996596	hsa-miR-198	CLIP-seq
MIRT996597	hsa-miR-3664-5p	CLIP-seq
MIRT996598	hsa-miR-4418	CLIP-seq
MIRT996599	hsa-miR-455-3p	CLIP-seq
MIRT996600	hsa-miR-4685-5p	CLIP-seq
MIRT996601	hsa-miR-4793-3p	CLIP-seq
MIRT996602	hsa-miR-509-3-5p	CLIP-seq
MIRT996603	hsa-miR-509-5p	CLIP-seq
MIRT1922735	hsa-miR-329	CLIP-seq
MIRT2229507	hsa-miR-1285	CLIP-seq
MIRT2229508	hsa-miR-1343	CLIP-seq
MIRT996595	hsa-miR-1976	CLIP-seq
MIRT996596	hsa-miR-198	CLIP-seq
MIRT2229509	hsa-miR-296-5p	CLIP-seq
MIRT2229510	hsa-miR-3187-5p	CLIP-seq
MIRT2229511	hsa-miR-3194-3p	CLIP-seq
MIRT2229512	hsa-miR-326	CLIP-seq
MIRT1922735	hsa-miR-329	CLIP-seq
MIRT2229513	hsa-miR-330-5p	CLIP-seq
MIRT2229514	hsa-miR-3622b-5p	CLIP-seq
MIRT996597	hsa-miR-3664-5p	CLIP-seq
MIRT2229515	hsa-miR-378g	CLIP-seq
MIRT2229516	hsa-miR-3910	CLIP-seq
MIRT2229517	hsa-miR-3922-5p	CLIP-seq
MIRT2229518	hsa-miR-4290	CLIP-seq
MIRT2229519	hsa-miR-4314	CLIP-seq
MIRT996598	hsa-miR-4418	CLIP-seq
MIRT2229520	hsa-miR-4486	CLIP-seq
MIRT996599	hsa-miR-455-3p	CLIP-seq
MIRT2229521	hsa-miR-4639-3p	CLIP-seq
MIRT2229522	hsa-miR-4640-5p	CLIP-seq
MIRT2229523	hsa-miR-4667-3p	CLIP-seq
MIRT2229524	hsa-miR-4667-5p	CLIP-seq
MIRT996600	hsa-miR-4685-5p	CLIP-seq
MIRT2229525	hsa-miR-4700-5p	CLIP-seq
MIRT2229526	hsa-miR-4726-5p	CLIP-seq
MIRT996601	hsa-miR-4793-3p	CLIP-seq
MIRT2229527	hsa-miR-4797-5p	CLIP-seq
MIRT996602	hsa-miR-509-3-5p	CLIP-seq
MIRT996603	hsa-miR-509-5p	CLIP-seq
MIRT2229528	hsa-miR-612	CLIP-seq
MIRT2229529	hsa-miR-637	CLIP-seq
MIRT2229530	hsa-miR-767-3p	CLIP-seq
MIRT1922735	hsa-miR-329	CLIP-seq

Gene ontology (GO) Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001725	Component	Stress fiber	IDA	15095401
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	15095401, 16361249, 24880667, 32296183
GO:0005634	Component	Nucleus	IDA	15095401
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	10352228
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IBA
GO:0005856	Component	Cytoskeleton	IEA
GO:0007015	Process	Actin filament organization	IBA
GO:0007097	Process	Nuclear migration	IEA
GO:0014704	Component	Intercalated disc	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0032059	Component	Bleb	IEA
GO:0042802	Function	Identical protein binding	IPI	18239683, 18786395
GO:0042995	Component	Cell projection	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	15095401
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	16361249
GO:0051015	Function	Actin filament binding	IBA
GO:0051492	Process	Regulation of stress fiber assembly	IMP	16361249
GO:0051496	Process	Positive regulation of stress fiber assembly	IBA
GO:0051496	Process	Positive regulation of stress fiber assembly	IDA	15095401
GO:0051660	Process	Establishment of centrosome localization	IEA

Other IDs

• MIM: 606881
• HGNC: 17905
• e!Ensembl: ENSG00000135723

Protein

• UniProt ID: Q9Y613
• Protein name: FH1/FH2 domain-containing protein 1 (Formin homolog overexpressed in spleen 1) (FHOS) (Formin homology 2 domain-containing protein 1)
• Protein function: Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically
• PDB: 3DAD , 6XF1 , 6XF2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02181	FH2	616 → 988	Formin Homology 2 Domain	Family
  PF18382	Formin_GBD_N	17 → 115	Formin N-terminal GTPase-binding domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. Highly expressed in spleen.
• Sequence:

  MAGGEDRGDGEPVSVVTVRVQYLEDTDPFACANFPEPRRAPTCSLDGALPLGAQIPAVHR
  LLGAPLKLEDCALQVSPSGYYLDTELSLEEQREMLEGFYEEISKGRKPTLILRTQLSVRV
  NAILEKLYSSSGPELRRSLFSLKQIFQEDKDLVPEFVHSEGLSCLIRVGAAADHNYQSYI
  LRALGQLMLFVDGMLGVVAHSDTIQWLYTLCASLSRLVVKTALKLLLVFVEYSENNAPLF
  IRAVNSVASTTGAPPWANLVSILEEKNGADPELLVYTVTLINKTLAALPDQDSFYDVTDA
  LEQQGMEALVQRHLGTAGTDVDLRTQLVLYENALKLEDGDIEEAPGAGGRRERRKPSSEE
  GKRSRRSLEGGGCPARAPEPGPTGPASPVGPTSSTGPALLTGPASSPVGPPSGLQASVNL
  FPTISVAPSADTSSERSIYKARFLENVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDA
  RQLWDSPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAEPIWELPTRAPRLS
  IGDLDFSDLGEDEDQDMLNVESVEAGKDIPAPSPPLPLLSGVPPPPPLPPPPPIKGPFPP
  PPPLPLAAPLPHSVPDSSALPTKRKTVKLFWRELKLAGGHGVSASRFGPCATLWASLDPV
  SVDTARLEHLFESRAKEVLPSKKAGEGRRTMTTVLDPKRSNAINIGLTTLPPVHVIKAAL
  LNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDIPLGPAENFLMTLASIGGLAAR
  LQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGSQSSGFE
  LSYLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLG
  QLERRSRAAEESLRSLAKHELAPALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLY
  LGYTPQAAREVRIMQFCHTLREFALEYRTCRERVLQQQQKQATYRERNKTRGRMITETEK
  FSGVAGEAPSNPSVPVAVSSGPGRGDADSHASMKSLLTSRPEDTTHNRRSRGMVQSSSPI
  MPTVGPSTASPEEPPGSSLPSDTSDEIMDLLVQSVTKSSPRALAARERKRSRGNRKSLRR
  TLKSGLGDDLVQALGLSKGPGLEV

• Sequence length: 1164

Pathways

KEGG Pathway:

Salmonella infection

Related Genes

No strongly related genes found yet for FHOD1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to FHOD1.