FER1L6 (fer-1 like family member 6)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 654463
• Gene name: Fer-1 like family member 6
• Gene symbol: FER1L6
• Synonyms (NCBI Gene): C8ORFK23
• Chromosome: 8
• Chromosome location: 8q24.13

miRNA Show/Hide all (10)

miRTarBase ID	miRNA	Experiments	Reference
MIRT2387967	hsa-miR-1207-5p	CLIP-seq
MIRT2387968	hsa-miR-1827	CLIP-seq
MIRT2387969	hsa-miR-1909	CLIP-seq
MIRT2387970	hsa-miR-3612	CLIP-seq
MIRT2387971	hsa-miR-432	CLIP-seq
MIRT2387972	hsa-miR-4443	CLIP-seq
MIRT2387973	hsa-miR-4763-3p	CLIP-seq
MIRT2387974	hsa-miR-650	CLIP-seq
MIRT2387975	hsa-miR-890	CLIP-seq
MIRT2387976	hsa-miR-940	CLIP-seq

Gene ontology (GO) Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005544	Function	Calcium-dependent phospholipid binding	ISS
GO:0005802	Component	Trans-Golgi network	IDA	26707827
GO:0005886	Component	Plasma membrane	IDA	26707827
GO:0005886	Component	Plasma membrane	ISS
GO:0007519	Process	Skeletal muscle tissue development	ISS
GO:0009617	Process	Response to bacterium	IEA
GO:0010628	Process	Positive regulation of gene expression	IBA
GO:0016020	Component	Membrane	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	ISS
GO:0048738	Process	Cardiac muscle tissue development	ISS
GO:0055037	Component	Recycling endosome	IDA	26707827

Other IDs

• MIM: 620884
• HGNC: 28065
• e!Ensembl: ENSG00000214814

Protein

• UniProt ID: Q2WGJ9
• Protein name: Fer-1-like protein 6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00168	C2	1356 → 1464	C2 domain	Domain
  PF00168	C2	243 → 357	C2 domain	Domain
  PF00168	C2	826 → 930	C2 domain	Domain
  PF00168	C2	83 → 184	C2 domain	Domain
  PF00168	C2	1596 → 1730	C2 domain	Domain
  PF00168	C2	1004 → 1098	C2 domain	Domain
  PF08150	FerB	712 → 784	FerB (NUC096) domain	Domain
  PF08151	FerI	187 → 236	FerI (NUC094) domain	Domain
  PF16165	Ferlin_C	1760 → 1853	Ferlin C-terminus	Family

• Sequence:

  MFGLKVKKKRNKAEKGLILANKAAKDSQGDTEALQEEPSHQEGPRGDLVHDDASIFPVPS
  ASPKRRSKLLTKIHDGEVRSQNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEG
  TNSPFYNEYFVFDFIGPQVHLFDKIIKISVFHHKLIGSVLIGSFKVDLGTVYNQPGHQFC
  NKWALLTDPGDIRTGTKGYLKCDISVMGKGDVLKTSPKTSDTEEPIEKNLLIPNGFPLER
  PWARFYVRLYKAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCA
  DPVWHEQVIFKEMFPPLCRRVKIQVWDEGSMNDVALATHFIDLKKISNEQDGDKGFLPTF
  GPAWINLYGSPRNHSLMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALK
  ELKLPSKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFL
  LFGAFFEATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQ
  GDVAHDVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNML
  EKMADFLEESIEEVRELIKISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLD
  KKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVDEPQHTIPDVF
  IWMLSNNRRVAYARIASKDLLYSPVAGQMGKHCGKIKTHFLKPPGKRPAGWSVQAKVDVY
  LWLGSIKHASAILDNLPVGYEAEMSSKGAGTNHPPSNLLYQEQHVFQLRAHMYQARGLIA
  ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV
  ELYDSDAVGKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELLQVP
  PSGLQGLPPVEPPDITQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIE
  CGGQGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTY
  TINYLKQFLCKLREPLAPITQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVE
  PPPTVVPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKR
  TIADESAENVIDWWSKYYASLKKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDK
  MLKKKPKDDGIPNLAILQIYDGDLESEFNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGK
  FKGSFCIYKSPQDSSSEDSGQLRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPY
  IVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGET
  KIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHPGKIQ
  IGNQVFSGKTIFTEEDTDETVESYEHLALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDK
  PGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQK
  SSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFS
  LEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENASEET
  KISIFQQKRVRGWWPFSKSKELTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPNRPD
  TSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIVVGS

• Sequence length: 1857

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Gastric cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Bipolar Disorder	Bipolar Disorder	GWASCAT_DG	31164008		★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	31164008		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	31164008		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for FER1L6.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to FER1L6.