FDCSP (follicular dendritic cell secreted protein)

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Gene Gene information from NCBI Gene database.
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Entrez ID 260436
Gene name Follicular dendritic cell secreted protein
Gene symbol FDCSP
Synonyms (NCBI Gene)
C4orf7FDC-SP
Chromosome 4
Chromosome location 4q13.3|4q13
Summary This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by p
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
2
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GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
607241 19215 ENSG00000181617
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NFU4
Protein name Follicular dendritic cell secreted peptide (FDC secreted protein) (FDC-SP)
Protein function Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15215 FDC-SP 18 → 82 Follicular dendritic cell secreted peptide Family
Tissue specificity TISSUE SPECIFICITY: Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. {ECO:0000269|PubMed:12193705}.
Sequence
Sequence length 85
Interactions View interactions

No strongly related genes found yet for FDCSP.

No additional diseases found yet through genes similar to FDCSP.