FCRLA (Fc receptor like A)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 84824
• Gene name: Fc receptor like A
• Gene symbol: FCRLA
• Synonyms (NCBI Gene): FCRL, FCRL1, FCRLM1, FCRLX, FCRLb, FCRLc1, FCRLc2, FCRLd, FCRLe, FCRX, FREB
• Chromosome: 1
• Chromosome location: 1q23.3
• Summary: This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selective

miRNA Show/Hide all (31)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017269	hsa-miR-335-5p	Microarray	18185580
MIRT994197	hsa-miR-1224-3p	CLIP-seq
MIRT994198	hsa-miR-1260	CLIP-seq
MIRT994199	hsa-miR-1260b	CLIP-seq
MIRT994200	hsa-miR-1280	CLIP-seq
MIRT994201	hsa-miR-141	CLIP-seq
MIRT994202	hsa-miR-200a	CLIP-seq
MIRT994203	hsa-miR-323-3p	CLIP-seq
MIRT994204	hsa-miR-3612	CLIP-seq
MIRT994205	hsa-miR-361-3p	CLIP-seq
MIRT994206	hsa-miR-3652	CLIP-seq
MIRT994207	hsa-miR-4430	CLIP-seq
MIRT994208	hsa-miR-4443	CLIP-seq
MIRT994209	hsa-miR-485-5p	CLIP-seq
MIRT994210	hsa-miR-495	CLIP-seq
MIRT994211	hsa-miR-606	CLIP-seq
MIRT994212	hsa-miR-650	CLIP-seq
MIRT994213	hsa-miR-1229	CLIP-seq
MIRT994214	hsa-miR-1243	CLIP-seq
MIRT994215	hsa-miR-331-3p	CLIP-seq
MIRT994216	hsa-miR-3654	CLIP-seq
MIRT994217	hsa-miR-410	CLIP-seq
MIRT994218	hsa-miR-4699-3p	CLIP-seq
MIRT994219	hsa-miR-4735-5p	CLIP-seq
MIRT994220	hsa-miR-513a-3p	CLIP-seq
MIRT994221	hsa-miR-618	CLIP-seq
MIRT994197	hsa-miR-1224-3p	CLIP-seq
MIRT994198	hsa-miR-1260	CLIP-seq
MIRT994199	hsa-miR-1260b	CLIP-seq
MIRT994200	hsa-miR-1280	CLIP-seq
MIRT994205	hsa-miR-361-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IBA
GO:0005737	Component	Cytoplasm	IDA	15815692
GO:0005737	Component	Cytoplasm	IEA
GO:0006955	Process	Immune response	IBA
GO:0007166	Process	Cell surface receptor signaling pathway	IBA
GO:0009897	Component	External side of plasma membrane	IBA
GO:0030154	Process	Cell differentiation	IEA

Other IDs

• MIM: 606891
• HGNC: 18504
• e!Ensembl: ENSG00000132185

Protein

• UniProt ID: Q7L513
• Protein name: Fc receptor-like A (Fc receptor homolog expressed in B-cells) (Fc receptor-like and mucin-like protein 1) (Fc receptor-like protein) (Fc receptor-related protein X) (FcRX)
• Protein function: May be implicated in B-cell differentiation and lymphomagenesis.
• PDB: 4HWN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13895	Ig_2	79 → 165	Immunoglobulin domain	Domain
  PF13895	Ig_2	171 → 260	Immunoglobulin domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed specifically in primary and secondary lymphoid tissues like lymph node, spleen and tonsil. Specifically expressed in B-cells with a high level in normal germinal center B-cells, centroblasts and in a subset of diffuse large B
• Sequence:

  MKLGCVLMAWALYLSLGVLWVAQMLLAASFETLQCEGPVCTEESSCHTEDDLTDAREAGF
  QVKAYTFSEPFHLIVSYDWLILQGPAKPVFEGDLLVLRCQAWQDWPLTQVTFYRDGSALG
  PPGPNREFSITVVQKADSGHYHCSGIFQSPGPGIPETASVVAITVQELFPAPILRAVPSA
  EPQAGSPMTLSCQTKLPLQRSAARLLFSFYKDGRIVQSRGLSSEFQIPTASEDHSGSYWC
  EAATEDNQVWKQSPQLEIRVQGASSSAAPPTLNPAPQKSAAPGTAPEEAPGPLPPPPTPS
  SEDPGFSSPLGMPDPHLYHQMGLLLKHMQDVRVLLGHLLMELRELSGHRKPGTTKATAE

• Sequence length: 359

Related Genes

No strongly related genes found yet for FCRLA.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to FCRLA.