FCMR (Fc mu receptor)

Download as csv Download as pdf

Log in to save this analysis

Save This Analysis

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 9214
• Gene name: Fc mu receptor
• Gene symbol: FCMR
• Synonyms (NCBI Gene): FAIM3, FcmuR, IgM FcR, TOSO
• Chromosome: 1
• Chromosome location: 1q32.1
• Summary: Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]

miRNA Show/Hide all (18)

miRTarBase ID	miRNA	Experiments	Reference
MIRT721194	hsa-miR-95-5p	HITS-CLIP	19536157
MIRT721193	hsa-miR-1224-3p	HITS-CLIP	19536157
MIRT721192	hsa-miR-5696	HITS-CLIP	19536157
MIRT721191	hsa-miR-579-3p	HITS-CLIP	19536157
MIRT721190	hsa-miR-664b-3p	HITS-CLIP	19536157
MIRT721189	hsa-miR-188-3p	HITS-CLIP	19536157
MIRT721188	hsa-miR-1260a	HITS-CLIP	19536157
MIRT721187	hsa-miR-1260b	HITS-CLIP	19536157
MIRT721186	hsa-miR-3156-3p	HITS-CLIP	19536157
MIRT740368	hsa-miR-95-5p	HITS-CLIP	19536157
MIRT740369	hsa-miR-1224-3p	HITS-CLIP	19536157
MIRT740370	hsa-miR-5696	HITS-CLIP	19536157
MIRT740371	hsa-miR-579-3p	HITS-CLIP	19536157
MIRT740372	hsa-miR-664b-3p	HITS-CLIP	19536157
MIRT740373	hsa-miR-188-3p	HITS-CLIP	19536157
MIRT740374	hsa-miR-1260a	HITS-CLIP	19536157
MIRT740375	hsa-miR-1260b	HITS-CLIP	19536157
MIRT740376	hsa-miR-3156-3p	HITS-CLIP	19536157

Gene ontology (GO) Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001790	Function	Polymeric immunoglobulin binding	IDA	36949194, 37095205
GO:0001791	Function	IgM binding	ISS
GO:0002172	Function	High-affinity IgM receptor activity	IDA	19858324
GO:0002376	Process	Immune system process	IEA
GO:0002414	Process	Immunoglobulin transcytosis in epithelial cells	ISS
GO:0002455	Process	Humoral immune response mediated by circulating immunoglobulin	ISS
GO:0004888	Function	Transmembrane signaling receptor activity	IBA
GO:0005515	Function	Protein binding	IPI	36949194
GO:0005576	Component	Extracellular region	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	21908732
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	19858324, 21908732
GO:0005886	Component	Plasma membrane	IEA
GO:0006968	Process	Cellular defense response	TAS	9586636
GO:0007165	Process	Signal transduction	IBA
GO:0016020	Component	Membrane	IEA
GO:0031901	Component	Early endosome membrane	IDA	21908732
GO:0031901	Component	Early endosome membrane	IEA
GO:0032588	Component	Trans-Golgi network membrane	IDA	21908732
GO:0038093	Process	Fc receptor signaling pathway	IEA
GO:0043066	Process	Negative regulation of apoptotic process	TAS	9586636
GO:0050855	Process	Regulation of B cell receptor signaling pathway	ISS
GO:0160006	Process	Fc receptor-mediated immune complex endocytosis	IDA	21908732

Other IDs

• MIM: 606015
• HGNC: 14315
• e!Ensembl: ENSG00000162894

Protein

• UniProt ID: O60667
• Protein name: Immunoglobulin mu Fc receptor (IgM FcR) (Fas apoptotic inhibitory molecule 3) (FAIM3) (Regulator of Fas-induced apoptosis Toso)
• Protein function: High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM (PubMed:19858324, PubMed:22675200, PubMed:36949194, PubMed:37095205). Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocyt
• PDB: 7YSG , 7YTC , 7YTD , 7YTE , 8BPE , 8BPF , 8BPG
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	20 → 123	Immunoglobulin V-set domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed by CD19-positive B cells and CD4-positive and CD8-positive T cell populations in primary and secondary lymphoid tissues (at protein level). Among B cell subsets, detected in a subset of bone marrow pro- and pre-B cells, in mo
• Sequence:

  MDFWLWPLYFLPVSGALRILPEVKVEGELGGSVTIKCPLPEMHVRIYLCREMAGSGTCGT
  VVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVYACGAGMNTDRGKTQKVTL
  NVHSEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFVTRVTTPAQRGKVPPVHHSSP
  TTQITHRPRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHRQRALD
  YGSQSGREGQGFHILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQ
  RPRGSPRPRSQNNIYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVSESPWLHAPSL
  KTSCEYVSLYHQPAAMMEDSDSDDYINVPA

• Sequence length: 390

Related Genes

No strongly related genes found yet for FCMR.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to FCMR.