FCHSD1 (FCH and double SH3 domains 1)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 89848
• Gene name: FCH and double SH3 domains 1
• Gene symbol: FCHSD1
• Synonyms (NCBI Gene): NWK2
• Chromosome: 5
• Chromosome location: 5q31.3

miRNA Show/Hide all (101)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018693	hsa-miR-335-5p	Microarray	18185580
MIRT658176	hsa-miR-6856-3p	HITS-CLIP	23824327
MIRT658175	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT658174	hsa-miR-370-5p	HITS-CLIP	23824327
MIRT658173	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT658172	hsa-miR-4459	HITS-CLIP	23824327
MIRT658171	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT658170	hsa-miR-622	HITS-CLIP	23824327
MIRT658169	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT658168	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT658167	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT658166	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT658165	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT658164	hsa-miR-4264	HITS-CLIP	23824327
MIRT658163	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT658162	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT658161	hsa-miR-4749-3p	HITS-CLIP	23824327
MIRT658160	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT658159	hsa-miR-4279	HITS-CLIP	23824327
MIRT658158	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT658176	hsa-miR-6856-3p	HITS-CLIP	23824327
MIRT658175	hsa-miR-6769a-3p	HITS-CLIP	23824327
MIRT658174	hsa-miR-370-5p	HITS-CLIP	23824327
MIRT658173	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT658172	hsa-miR-4459	HITS-CLIP	23824327
MIRT658171	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT658170	hsa-miR-622	HITS-CLIP	23824327
MIRT658169	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT658168	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT658167	hsa-miR-331-3p	HITS-CLIP	23824327
MIRT658166	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT658165	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT658164	hsa-miR-4264	HITS-CLIP	23824327
MIRT658163	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT658162	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT658161	hsa-miR-4749-3p	HITS-CLIP	23824327
MIRT658160	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT658159	hsa-miR-4279	HITS-CLIP	23824327
MIRT658158	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT994001	hsa-miR-103a	CLIP-seq
MIRT994002	hsa-miR-107	CLIP-seq
MIRT994003	hsa-miR-15a	CLIP-seq
MIRT994004	hsa-miR-15b	CLIP-seq
MIRT994005	hsa-miR-16	CLIP-seq
MIRT994006	hsa-miR-195	CLIP-seq
MIRT994007	hsa-miR-28-3p	CLIP-seq
MIRT994008	hsa-miR-3140-3p	CLIP-seq
MIRT994009	hsa-miR-3153	CLIP-seq
MIRT994010	hsa-miR-3194-3p	CLIP-seq
MIRT994011	hsa-miR-424	CLIP-seq
MIRT994012	hsa-miR-4267	CLIP-seq
MIRT994013	hsa-miR-4640-5p	CLIP-seq
MIRT994014	hsa-miR-4687-3p	CLIP-seq
MIRT994015	hsa-miR-4726-5p	CLIP-seq
MIRT994016	hsa-miR-497	CLIP-seq
MIRT994017	hsa-miR-541	CLIP-seq
MIRT994018	hsa-miR-572	CLIP-seq
MIRT994019	hsa-miR-583	CLIP-seq
MIRT994020	hsa-miR-605	CLIP-seq
MIRT994021	hsa-miR-606	CLIP-seq
MIRT994022	hsa-miR-637	CLIP-seq
MIRT994023	hsa-miR-647	CLIP-seq
MIRT994024	hsa-miR-654-5p	CLIP-seq
MIRT994025	hsa-miR-885-5p	CLIP-seq
MIRT1994750	hsa-miR-218	CLIP-seq
MIRT1994751	hsa-miR-3134	CLIP-seq
MIRT1994752	hsa-miR-4289	CLIP-seq
MIRT1994753	hsa-miR-4534	CLIP-seq
MIRT1994754	hsa-miR-4733-5p	CLIP-seq
MIRT1994755	hsa-miR-634	CLIP-seq
MIRT2228914	hsa-miR-1266	CLIP-seq
MIRT2228915	hsa-miR-3155	CLIP-seq
MIRT2228916	hsa-miR-3155b	CLIP-seq
MIRT2228917	hsa-miR-3664-3p	CLIP-seq
MIRT2228918	hsa-miR-4254	CLIP-seq
MIRT2228919	hsa-miR-4505	CLIP-seq
MIRT2228920	hsa-miR-4518	CLIP-seq
MIRT2228921	hsa-miR-4653-3p	CLIP-seq
MIRT2228922	hsa-miR-4709-5p	CLIP-seq
MIRT2228923	hsa-miR-4731-5p	CLIP-seq
MIRT2228924	hsa-miR-484	CLIP-seq
MIRT2228925	hsa-miR-619	CLIP-seq
MIRT994022	hsa-miR-637	CLIP-seq
MIRT994007	hsa-miR-28-3p	CLIP-seq
MIRT994021	hsa-miR-606	CLIP-seq
MIRT994022	hsa-miR-637	CLIP-seq
MIRT2449584	hsa-miR-125a-5p	CLIP-seq
MIRT2449585	hsa-miR-125b	CLIP-seq
MIRT2449586	hsa-miR-4319	CLIP-seq
MIRT2449587	hsa-miR-4642	CLIP-seq
MIRT2449588	hsa-miR-4720-5p	CLIP-seq
MIRT2449589	hsa-miR-4725-5p	CLIP-seq
MIRT2449590	hsa-miR-4732-3p	CLIP-seq
MIRT2449591	hsa-miR-4799-3p	CLIP-seq
MIRT2449592	hsa-miR-504	CLIP-seq
MIRT2449593	hsa-miR-670	CLIP-seq
MIRT2680911	hsa-miR-3126-5p	CLIP-seq
MIRT2680912	hsa-miR-361-3p	CLIP-seq
MIRT994012	hsa-miR-4267	CLIP-seq
MIRT2680913	hsa-miR-4419a	CLIP-seq
MIRT2680914	hsa-miR-4510	CLIP-seq

Gene ontology (GO) Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0007274	Process	Neuromuscular synaptic transmission	IBA
GO:0008289	Function	Lipid binding	IEA
GO:0010467	Process	Gene expression	IEA
GO:0030833	Process	Regulation of actin filament polymerization	IBA
GO:0030833	Process	Regulation of actin filament polymerization	IEA
GO:0030838	Process	Positive regulation of actin filament polymerization	IEA
GO:0030838	Process	Positive regulation of actin filament polymerization	ISS
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031594	Component	Neuromuscular junction	IBA
GO:0032437	Component	Cuticular plate	IEA
GO:0032437	Component	Cuticular plate	ISS
GO:0032991	Component	Protein-containing complex	IEA
GO:0042542	Process	Response to hydrogen peroxide	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0051170	Process	Import into nucleus	IEA
GO:0051495	Process	Positive regulation of cytoskeleton organization	IEA
GO:0055037	Component	Recycling endosome	IBA
GO:0061024	Process	Membrane organization	IEA
GO:1901652	Process	Response to peptide	IEA
GO:1902905	Process	Positive regulation of supramolecular fiber organization	IEA

Other IDs

• MIM: 617555
• HGNC: 25463
• e!Ensembl: ENSG00000197948

Protein

• UniProt ID: Q86WN1
• Protein name: F-BAR and double SH3 domains protein 1 (Protein nervous wreck 2) (NWK2)
• Protein function: Promotes actin polymerization mediated by SNX9 and WASL.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00611	FCH	21 → 102	Fes/CIP4, and EFC/F-BAR homology domain	Family
  PF14604	SH3_9	553 → 605	Variant SH3 domain	Domain
  PF14604	SH3_9	475 → 525	Variant SH3 domain	Domain

• Sequence:

  MQPPPRKVKPAQEVKLRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKL
  AGPFLKREGHRSGEMDSRGRTVFGAWRCLLDATVAGGQTRLQASDRYRDLAGGTGRSAKE
  QVLRKGTENLQRAQAEVLQSVRELSRSRKLYGQRERVWALAQEKAADVQARLNRSDHGIF
  HSRTSLQKLSTKLSAQSAQYSQQLQAARNEYLLNLVATNAHLDHYYQEELPALLKALVSE
  LSEHLRDPLTSLSHTELEAAEVILEHAHRGEQTTSQVSWEQDLKLFLQEPGVFSPTPPQQ
  FQPAGTDQVCVLEWGAEGVAGKSGLEKEVQRLTSRAARDYKIQNHGHRVLQRLEQRRQQA
  SEREAPSIEQRLQEVRESIRRAQVSQVKGAARLALLQGAGLDVERWLKPAMTQAQDEVEQ
  ERRLSEARLSQRDLSPTAEDAELSDFEECEETGELFEEPAPQALATRALPCPAHVVFRYQ
  AGREDELTITEGEWLEVIEEGDADEWVKARNQHGEVGFVPERYLNFPDLSLPESSQDSDN
  PCGAEPTAFLAQALYSYTGQSAEELSFPEGALIRLLPRAQDGVDDGFWRGEFGGRVGVFP
  SLLVEELLGPPGPPELSDPEQMLPSPSPPSFSPPAPTSVLDGPPAPVLPGDKALDFPGFL
  DMMAPRLRPMRPPPPPPAKAPDPGHPDPLT

• Sequence length: 690

Related Genes

No strongly related genes found yet for FCHSD1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to FCHSD1.