FBXW5 (F-box and WD repeat domain containing 5)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 54461
• Gene name: F-box and WD repeat domain containing 5
• Gene symbol: FBXW5
• Synonyms (NCBI Gene): Fbw5
• Chromosome: 9
• Chromosome location: 9q34.3
• Summary: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cul

miRNA Show/Hide all (47)

miRTarBase ID	miRNA	Experiments	Reference
MIRT993461	hsa-miR-140-3p	CLIP-seq
MIRT993462	hsa-miR-665	CLIP-seq
MIRT1994674	hsa-miR-1291	CLIP-seq
MIRT993461	hsa-miR-140-3p	CLIP-seq
MIRT1994675	hsa-miR-150	CLIP-seq
MIRT1994676	hsa-miR-3127-5p	CLIP-seq
MIRT1994677	hsa-miR-3918	CLIP-seq
MIRT1994678	hsa-miR-452	CLIP-seq
MIRT1994679	hsa-miR-4658	CLIP-seq
MIRT1994680	hsa-miR-4676-3p	CLIP-seq
MIRT1994681	hsa-miR-4758-5p	CLIP-seq
MIRT1994682	hsa-miR-4765	CLIP-seq
MIRT1994683	hsa-miR-887	CLIP-seq
MIRT993462	hsa-miR-665	CLIP-seq
MIRT1994678	hsa-miR-452	CLIP-seq
MIRT1994680	hsa-miR-4676-3p	CLIP-seq
MIRT2387953	hsa-miR-4715-3p	CLIP-seq
MIRT2387954	hsa-miR-4722-3p	CLIP-seq
MIRT2532324	hsa-miR-1207-3p	CLIP-seq
MIRT2532325	hsa-miR-125a-3p	CLIP-seq
MIRT2532326	hsa-miR-18a	CLIP-seq
MIRT2532327	hsa-miR-18b	CLIP-seq
MIRT2532328	hsa-miR-296-5p	CLIP-seq
MIRT1994677	hsa-miR-3918	CLIP-seq
MIRT2532329	hsa-miR-3934	CLIP-seq
MIRT2532330	hsa-miR-4293	CLIP-seq
MIRT2532331	hsa-miR-4640-5p	CLIP-seq
MIRT2532332	hsa-miR-4685-5p	CLIP-seq
MIRT2532333	hsa-miR-4700-3p	CLIP-seq
MIRT2387953	hsa-miR-4715-3p	CLIP-seq
MIRT2532334	hsa-miR-4726-5p	CLIP-seq
MIRT2532335	hsa-miR-4735-3p	CLIP-seq
MIRT2532336	hsa-miR-4758-3p	CLIP-seq
MIRT2532337	hsa-miR-596	CLIP-seq
MIRT2532338	hsa-miR-764	CLIP-seq
MIRT2532324	hsa-miR-1207-3p	CLIP-seq
MIRT2532326	hsa-miR-18a	CLIP-seq
MIRT2532327	hsa-miR-18b	CLIP-seq
MIRT2532328	hsa-miR-296-5p	CLIP-seq
MIRT1994677	hsa-miR-3918	CLIP-seq
MIRT2532331	hsa-miR-4640-5p	CLIP-seq
MIRT2532332	hsa-miR-4685-5p	CLIP-seq
MIRT2532333	hsa-miR-4700-3p	CLIP-seq
MIRT2387953	hsa-miR-4715-3p	CLIP-seq
MIRT2532334	hsa-miR-4726-5p	CLIP-seq
MIRT2532335	hsa-miR-4735-3p	CLIP-seq
MIRT2532336	hsa-miR-4758-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15070733, 18381890, 19159283, 21725316, 22632967, 23314863, 25416956, 27705803, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IDA	21725316
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007088	Process	Regulation of mitotic nuclear division	IEA
GO:0010564	Process	Regulation of cell cycle process	IEA
GO:0010824	Process	Regulation of centrosome duplication	IMP	21725316
GO:0016567	Process	Protein ubiquitination	IDA	18381890, 21725316
GO:0016567	Process	Protein ubiquitination	IEA
GO:0019005	Component	SCF ubiquitin ligase complex	IDA	21725316
GO:0019005	Component	SCF ubiquitin ligase complex	IEA
GO:0019901	Function	Protein kinase binding	IPI	21725316
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA	21725316
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	18381890
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IDA	18381890
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IEA

Other IDs

• MIM: 609072
• HGNC: 13613
• e!Ensembl: ENSG00000159069

Protein

• UniProt ID: Q969U6
• Protein name: F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)
• Protein function: Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiqu
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	82 → 120	WD domain, G-beta repeat	Repeat
  PF12937	F-box-like	6 → 52	F-box-like	Domain

• Sequence:

  MDEGGTPLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQFYRYYQVARDV
  PRHPAAMSWYEEFQRLYDTVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVKIWS
  NDLTISLLHSADMRPYNWSYTQFSQFNKDDSLLLASGVFLGPHNSSSGEIAVISLDSFAL
  LSRVRNKPYDVFGCWLTETSLISGNLHRIGDITSCSVLWLNNAFQDVESENVNVVKRLFK
  IQNLNASTVRTVMVADCSRFDSPDLLLEAGDPATSPCRIFDLGSDNEEVVAGPAPAHAKE
  GLRHFLDRVLEGRAQPQLSERMLETKVAELLAQGHTKPPERSATGAKSKYLIFTTGCLTY
  SPHQIGIKQILPHQMTTAGPVLGEGRGSDAFFDALDHVIDIHGHIIGMGLSPDNRYLYVN
  SRAWPNGAVVADPMQPPPIAEEIDLLVFDLKTMREVRRALRAHRAYTPNDECFFIFLDVS
  RDFVASGAEDRHGYIWDRHYNICLARLRHEDVVNSVVFSPQEQELLLTASDDATIKAWRS
  PRTMRVLQAPRPRPRTFFSWLASQRR

• Sequence length: 566

Pathways

Reactome Pathway

Neddylation

Antigen processing: Ubiquitination & Proteasome degradation

Related Genes

No strongly related genes found yet for FBXW5.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to FBXW5.