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Gene Gene information from NCBI Gene database.
Entrez ID 26190
Gene name F-box and WD repeat domain containing 2
Gene symbol FBXW2
Synonyms (NCBI Gene)
FBW2Fwd2Md6
Chromosome 9
Chromosome location 9q33.2
Summary F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In f
miRNA miRNA information provided by mirtarbase database.
1322 Show/Hide all (1322)
miRTarBase ID miRNA Experiments Reference
MIRT024395 hsa-miR-215-5p Microarray 19074876
MIRT026356 hsa-miR-192-5p Microarray 19074876
MIRT052421 hsa-let-7a-5p CLASH 23622248
MIRT052115 hsa-let-7b-5p CLASH 23622248
MIRT046735 hsa-miR-222-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
5
GO ID Ontology Definition Evidence Reference
GO:0004842 Function Ubiquitin-protein transferase activity TAS 10531035
GO:0005515 Function Protein binding IPI 11238952, 15070733, 21145461, 22632967, 22939624, 23108047, 23651062, 25036637, 27705803, 31391242, 32296183, 33961781
GO:0005829 Component Cytosol TAS
GO:0006508 Process Proteolysis TAS 10531035
GO:0036211 Process Protein modification process TAS 10531035
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609071 13608 ENSG00000119402
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UKT8
Protein name F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6)
Protein function Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00400 WD40 216 → 253 WD domain, G-beta repeat Repeat
PF00400 WD40 258 → 304 WD domain, G-beta repeat Repeat
PF00400 WD40 140 → 174 WD domain, G-beta repeat Repeat
PF00646 F-box 55 → 95 F-box domain Domain
Sequence
MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLL
PLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACT
EVWQTACKNLGWQIDDSVQDALHWK
KVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQC
VYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDI
LVSGSADFTVKVW
ALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYE
IKIW
PIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRV
IKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGEA
SWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG
Sequence length 454
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation