FBXO42 (F-box protein 42)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 54455
• Gene name: F-box protein 42
• Gene symbol: FBXO42
• Synonyms (NCBI Gene): Fbx42, JFK
• Chromosome: 1
• Chromosome location: 1p36.13
• Summary: Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F

miRNA Show/Hide all (78)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044952	hsa-miR-186-5p	CLASH	23622248
MIRT625828	hsa-miR-5193	HITS-CLIP	23824327
MIRT625827	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT625826	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT625825	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT625824	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT625823	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT625822	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT625821	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT645399	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT645398	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT645397	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT625820	hsa-miR-1281	HITS-CLIP	23824327
MIRT625828	hsa-miR-5193	HITS-CLIP	23824327
MIRT625827	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT625826	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT625825	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT625821	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT645399	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT645398	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT645397	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT625820	hsa-miR-1281	HITS-CLIP	23824327
MIRT625828	hsa-miR-5193	HITS-CLIP	23824327
MIRT625827	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT625826	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT625825	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT625824	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT625823	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT625822	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT625821	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT625820	hsa-miR-1281	HITS-CLIP	23824327
MIRT625828	hsa-miR-5193	HITS-CLIP	23824327
MIRT625827	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT625826	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT625825	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT625824	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT625823	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT625822	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT625821	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT645399	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT645398	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT645397	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT625820	hsa-miR-1281	HITS-CLIP	23824327
MIRT625828	hsa-miR-5193	HITS-CLIP	23824327
MIRT625827	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT625826	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT625825	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT625821	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT645399	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT645398	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT645397	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT625820	hsa-miR-1281	HITS-CLIP	23824327
MIRT625828	hsa-miR-5193	HITS-CLIP	23824327
MIRT625827	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT625826	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT625825	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT625824	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT625823	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT625822	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT625821	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT625820	hsa-miR-1281	HITS-CLIP	23824327
MIRT1994328	hsa-miR-105	CLIP-seq
MIRT1994329	hsa-miR-1910	CLIP-seq
MIRT1994330	hsa-miR-3148	CLIP-seq
MIRT1994331	hsa-miR-3154	CLIP-seq
MIRT1994332	hsa-miR-329	CLIP-seq
MIRT1994333	hsa-miR-362-3p	CLIP-seq
MIRT1994334	hsa-miR-3647-3p	CLIP-seq
MIRT1994335	hsa-miR-3941	CLIP-seq
MIRT1994336	hsa-miR-4264	CLIP-seq
MIRT1994337	hsa-miR-4446-5p	CLIP-seq
MIRT1994338	hsa-miR-455-3p	CLIP-seq
MIRT1994339	hsa-miR-466	CLIP-seq
MIRT1994340	hsa-miR-4672	CLIP-seq
MIRT1994341	hsa-miR-4797-3p	CLIP-seq
MIRT1994342	hsa-miR-603	CLIP-seq
MIRT1994343	hsa-miR-875-3p	CLIP-seq
MIRT2228374	hsa-miR-634	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25609649, 28514442, 30824926, 32814053, 33961781
GO:0019005	Component	SCF ubiquitin ligase complex	IBA
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IBA

Other IDs

• MIM: 609109
• HGNC: 29249
• e!Ensembl: ENSG00000037637

Protein

• UniProt ID: Q6P3S6
• Protein name: F-box only protein 42 (Just one F-box and Kelch domain-containing protein)
• Protein function: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07646	Kelch_2	231 → 277	Kelch motif	Repeat
  PF12937	F-box-like	47 → 89	F-box-like	Domain
  PF13415	Kelch_3	130 → 182		Domain

• Sequence:

  MASSSDSEDDSFMAVDQEETVLEGTMDQDEEPHPVLEAEETRHNRSMSELPEEVLEYILS
  FLSPYQEHKTAALVCKQWYRLIKGVAHQCYHGFMKAVQEGNIQWESRTYPYPGTPITQRF
  SHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLV
  VYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVI
  DDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILG
  GCGGPNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHPACRVGQCVVVFSQAPSG
  RAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTP
  SGSREGSLSPARGDGSPILNGGSLSPGTAAVGGSSLDSPVQAISPSTPSAPEGYDLKIGL
  SLAPRRGSLPDQKDLRLGSIDLNWDLKPASSSNPMDGMDNRTVGGSMRHPPEQTNGVHTP
  PHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPGSPGSQSLSSGETVP
  IPRPGPAQGDGHSLPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRV
  KWKVFNSSSVVGPPETSLHTVVQGRGELIIFGGLMDKKQNVKYYPKTNALYFVRAKR

• Sequence length: 717

Related Genes

No strongly related genes found yet for FBXO42.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to FBXO42.