FBXO3 (F-box protein 3)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 26273
• Gene name: F-box protein 3
• Gene symbol: FBXO3
• Synonyms (NCBI Gene): FBA, FBX3
• Chromosome: 11
• Chromosome location: 11p13
• Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box

miRNA Show/Hide all (153)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021627	hsa-miR-142-3p	Microarray	17612493
MIRT023410	hsa-miR-30b-5p	Sequencing	20371350
MIRT026514	hsa-miR-192-5p	Microarray	19074876
MIRT029469	hsa-miR-26b-5p	Microarray	19088304
MIRT030802	hsa-miR-21-5p	Microarray	18591254
MIRT032115	hsa-let-7d-5p	Sequencing	20371350
MIRT051338	hsa-miR-15a-5p	CLASH	23622248
MIRT051071	hsa-miR-16-5p	CLASH	23622248
MIRT050537	hsa-miR-20a-5p	CLASH	23622248
MIRT992021	hsa-miR-1298	CLIP-seq
MIRT992022	hsa-miR-142-5p	CLIP-seq
MIRT992023	hsa-miR-3167	CLIP-seq
MIRT992024	hsa-miR-340	CLIP-seq
MIRT992025	hsa-miR-3613-3p	CLIP-seq
MIRT992026	hsa-miR-410	CLIP-seq
MIRT992027	hsa-miR-4275	CLIP-seq
MIRT992028	hsa-miR-4428	CLIP-seq
MIRT992029	hsa-miR-4719	CLIP-seq
MIRT992030	hsa-miR-4764-3p	CLIP-seq
MIRT992031	hsa-miR-520d-5p	CLIP-seq
MIRT992032	hsa-miR-524-5p	CLIP-seq
MIRT992033	hsa-miR-568	CLIP-seq
MIRT992034	hsa-miR-618	CLIP-seq
MIRT992035	hsa-miR-668	CLIP-seq
MIRT992036	hsa-miR-876-5p	CLIP-seq
MIRT2228274	hsa-miR-1252	CLIP-seq
MIRT992021	hsa-miR-1298	CLIP-seq
MIRT2228275	hsa-miR-141	CLIP-seq
MIRT992022	hsa-miR-142-5p	CLIP-seq
MIRT2228276	hsa-miR-200a	CLIP-seq
MIRT2228277	hsa-miR-2053	CLIP-seq
MIRT2228278	hsa-miR-219-5p	CLIP-seq
MIRT2228279	hsa-miR-3074-5p	CLIP-seq
MIRT2228280	hsa-miR-3146	CLIP-seq
MIRT992023	hsa-miR-3167	CLIP-seq
MIRT992024	hsa-miR-340	CLIP-seq
MIRT2228281	hsa-miR-370	CLIP-seq
MIRT992028	hsa-miR-4428	CLIP-seq
MIRT2228282	hsa-miR-4521	CLIP-seq
MIRT2228283	hsa-miR-4635	CLIP-seq
MIRT2228284	hsa-miR-4699-3p	CLIP-seq
MIRT992029	hsa-miR-4719	CLIP-seq
MIRT2228285	hsa-miR-4782-3p	CLIP-seq
MIRT992033	hsa-miR-568	CLIP-seq
MIRT2228286	hsa-miR-569	CLIP-seq
MIRT992036	hsa-miR-876-5p	CLIP-seq
MIRT2531998	hsa-miR-1257	CLIP-seq
MIRT2531999	hsa-miR-1273f	CLIP-seq
MIRT992022	hsa-miR-142-5p	CLIP-seq
MIRT2532000	hsa-miR-143	CLIP-seq
MIRT2532001	hsa-miR-1915	CLIP-seq
MIRT2228277	hsa-miR-2053	CLIP-seq
MIRT2532002	hsa-miR-2115	CLIP-seq
MIRT2532003	hsa-miR-214	CLIP-seq
MIRT2532004	hsa-miR-2467-3p	CLIP-seq
MIRT2532005	hsa-miR-2861	CLIP-seq
MIRT2532006	hsa-miR-298	CLIP-seq
MIRT2228279	hsa-miR-3074-5p	CLIP-seq
MIRT2228280	hsa-miR-3146	CLIP-seq
MIRT2532007	hsa-miR-323-3p	CLIP-seq
MIRT2532008	hsa-miR-330-3p	CLIP-seq
MIRT2532009	hsa-miR-338-5p	CLIP-seq
MIRT992024	hsa-miR-340	CLIP-seq
MIRT2532010	hsa-miR-3611	CLIP-seq
MIRT992025	hsa-miR-3613-3p	CLIP-seq
MIRT2532011	hsa-miR-3619-5p	CLIP-seq
MIRT2532012	hsa-miR-3678-3p	CLIP-seq
MIRT2532013	hsa-miR-3690	CLIP-seq
MIRT2228281	hsa-miR-370	CLIP-seq
MIRT2532014	hsa-miR-371b-5p	CLIP-seq
MIRT2532015	hsa-miR-376c	CLIP-seq
MIRT2532016	hsa-miR-3918	CLIP-seq
MIRT2532017	hsa-miR-3919	CLIP-seq
MIRT2532018	hsa-miR-3925-5p	CLIP-seq
MIRT2532019	hsa-miR-4254	CLIP-seq
MIRT2532020	hsa-miR-4291	CLIP-seq
MIRT992028	hsa-miR-4428	CLIP-seq
MIRT2532021	hsa-miR-4461	CLIP-seq
MIRT2532022	hsa-miR-4473	CLIP-seq
MIRT2532023	hsa-miR-4512	CLIP-seq
MIRT2532024	hsa-miR-4659a-3p	CLIP-seq
MIRT2532025	hsa-miR-4659b-3p	CLIP-seq
MIRT2532026	hsa-miR-4677-3p	CLIP-seq
MIRT2532027	hsa-miR-4679	CLIP-seq
MIRT2532028	hsa-miR-4685-5p	CLIP-seq
MIRT2228284	hsa-miR-4699-3p	CLIP-seq
MIRT2532029	hsa-miR-4708-5p	CLIP-seq
MIRT992029	hsa-miR-4719	CLIP-seq
MIRT2532030	hsa-miR-4770	CLIP-seq
MIRT2532031	hsa-miR-4777-3p	CLIP-seq
MIRT2532032	hsa-miR-4793-5p	CLIP-seq
MIRT2532033	hsa-miR-494	CLIP-seq
MIRT2532034	hsa-miR-512-3p	CLIP-seq
MIRT2532035	hsa-miR-516a-3p	CLIP-seq
MIRT992031	hsa-miR-520d-5p	CLIP-seq
MIRT2532036	hsa-miR-520f	CLIP-seq
MIRT992032	hsa-miR-524-5p	CLIP-seq
MIRT2532037	hsa-miR-539	CLIP-seq
MIRT992033	hsa-miR-568	CLIP-seq
MIRT2228286	hsa-miR-569	CLIP-seq
MIRT2532038	hsa-miR-580	CLIP-seq
MIRT2532039	hsa-miR-597	CLIP-seq
MIRT2532040	hsa-miR-607	CLIP-seq
MIRT992035	hsa-miR-668	CLIP-seq
MIRT2532041	hsa-miR-7	CLIP-seq
MIRT2532042	hsa-miR-761	CLIP-seq
MIRT2532043	hsa-miR-922	CLIP-seq
MIRT2531999	hsa-miR-1273f	CLIP-seq
MIRT992022	hsa-miR-142-5p	CLIP-seq
MIRT2532000	hsa-miR-143	CLIP-seq
MIRT2228277	hsa-miR-2053	CLIP-seq
MIRT2532002	hsa-miR-2115	CLIP-seq
MIRT2532004	hsa-miR-2467-3p	CLIP-seq
MIRT2228279	hsa-miR-3074-5p	CLIP-seq
MIRT2228280	hsa-miR-3146	CLIP-seq
MIRT2532007	hsa-miR-323-3p	CLIP-seq
MIRT2532008	hsa-miR-330-3p	CLIP-seq
MIRT2532009	hsa-miR-338-5p	CLIP-seq
MIRT992024	hsa-miR-340	CLIP-seq
MIRT2532010	hsa-miR-3611	CLIP-seq
MIRT992025	hsa-miR-3613-3p	CLIP-seq
MIRT2532012	hsa-miR-3678-3p	CLIP-seq
MIRT2532013	hsa-miR-3690	CLIP-seq
MIRT2228281	hsa-miR-370	CLIP-seq
MIRT2532014	hsa-miR-371b-5p	CLIP-seq
MIRT2532015	hsa-miR-376c	CLIP-seq
MIRT2532017	hsa-miR-3919	CLIP-seq
MIRT2532018	hsa-miR-3925-5p	CLIP-seq
MIRT2532019	hsa-miR-4254	CLIP-seq
MIRT992028	hsa-miR-4428	CLIP-seq
MIRT2532021	hsa-miR-4461	CLIP-seq
MIRT2532022	hsa-miR-4473	CLIP-seq
MIRT2532024	hsa-miR-4659a-3p	CLIP-seq
MIRT2532025	hsa-miR-4659b-3p	CLIP-seq
MIRT2228284	hsa-miR-4699-3p	CLIP-seq
MIRT2532029	hsa-miR-4708-5p	CLIP-seq
MIRT992029	hsa-miR-4719	CLIP-seq
MIRT2532030	hsa-miR-4770	CLIP-seq
MIRT2532031	hsa-miR-4777-3p	CLIP-seq
MIRT2532032	hsa-miR-4793-5p	CLIP-seq
MIRT2532033	hsa-miR-494	CLIP-seq
MIRT2532034	hsa-miR-512-3p	CLIP-seq
MIRT2532035	hsa-miR-516a-3p	CLIP-seq
MIRT992031	hsa-miR-520d-5p	CLIP-seq
MIRT2532036	hsa-miR-520f	CLIP-seq
MIRT992032	hsa-miR-524-5p	CLIP-seq
MIRT2532037	hsa-miR-539	CLIP-seq
MIRT992033	hsa-miR-568	CLIP-seq
MIRT2228286	hsa-miR-569	CLIP-seq
MIRT2532038	hsa-miR-580	CLIP-seq
MIRT2532039	hsa-miR-597	CLIP-seq
MIRT992035	hsa-miR-668	CLIP-seq
MIRT2532041	hsa-miR-7	CLIP-seq

Gene ontology (GO) Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004842	Function	Ubiquitin-protein transferase activity	TAS	10531035
GO:0005515	Function	Protein binding	IPI	21145461, 21516116, 22190034, 22632967, 27705803, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	18809579
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	IDA
GO:0006366	Process	Transcription by RNA polymerase II	IDA	8692841
GO:0006508	Process	Proteolysis	TAS	10531035
GO:0016567	Process	Protein ubiquitination	IEA
GO:0019005	Component	SCF ubiquitin ligase complex	IDA	26037928
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA	26037928
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IEA
GO:0032496	Process	Response to lipopolysaccharide	IDA	26037928
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IDA	26037928
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IEA

Other IDs

• MIM: 609089
• HGNC: 13582
• e!Ensembl: ENSG00000110429

Protein

• UniProt ID: Q9UK99
• Protein name: F-box only protein 3
• Protein function: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:18809579, PubMed:26037928). Me
• PDB: 5HDW , 9KBD , 9KBF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00646	F-box	11 → 58	F-box domain	Domain
  PF04379	DUF525	294 → 384	ApaG domain	Family
  PF09346	SMI1_KNR4	121 → 251	SMI1 / KNR4 family (SUKH-1)	Domain

• Sequence:

  MAAMETETAPLTLESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCKKY
  WLISEEEKTQKNQCWKSLFIDTYSDVGRYIDHYAAIKKAWDDLKKYLEPRCPRMVLSLKE
  GAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPGLLGSMALSNHYRSEDLLDVDTA
  AGGFQQRQGLKYCLPLTFCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQMARNPAAIDMFI
  IGATFTDWFTSYVKNVVSGGFPIIRDQIFRYVHDPECVATTGDITVSVSTSFLPELSSVH
  PPHYFFTYRIRIEMSKDALPEKACQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISPGRV
  YEYTSCTTFSTTSGYMEGYYTFHFLYFKDKIFNVAIPRFHMACPTFRVSIARLEMGPDEY
  EEMEEEEEEEEEEDEDDDSADMDESDEDDEEERRRRVFDVPIRRRRCSRLF

• Sequence length: 471

Related Genes

No strongly related genes found yet for FBXO3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to FBXO3.