FBXO10 (F-box protein 10)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 26267
• Gene name: F-box protein 10
• Gene symbol: FBXO10
• Synonyms (NCBI Gene): FBX10, PRMT11
• Chromosome: 9
• Chromosome location: 9p13.2
• Summary: Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box pr

miRNA Show/Hide all (199)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045730	hsa-miR-125a-5p	CLASH	23622248
MIRT440659	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT440660	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT440659	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT727684	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT727683	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT727682	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT727681	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT727680	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT727679	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT440660	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT991205	hsa-miR-1207-3p	CLIP-seq
MIRT991206	hsa-miR-3188	CLIP-seq
MIRT991207	hsa-miR-3192	CLIP-seq
MIRT991208	hsa-miR-3689a-3p	CLIP-seq
MIRT991209	hsa-miR-3689c	CLIP-seq
MIRT991210	hsa-miR-4291	CLIP-seq
MIRT991211	hsa-miR-4310	CLIP-seq
MIRT991212	hsa-miR-4455	CLIP-seq
MIRT991213	hsa-miR-4728-5p	CLIP-seq
MIRT991214	hsa-miR-541	CLIP-seq
MIRT991215	hsa-miR-654-5p	CLIP-seq
MIRT991205	hsa-miR-1207-3p	CLIP-seq
MIRT1993924	hsa-miR-1236	CLIP-seq
MIRT1993925	hsa-miR-130a	CLIP-seq
MIRT1993926	hsa-miR-130b	CLIP-seq
MIRT1993927	hsa-miR-19a	CLIP-seq
MIRT1993928	hsa-miR-19b	CLIP-seq
MIRT1993929	hsa-miR-23a	CLIP-seq
MIRT1993930	hsa-miR-23b	CLIP-seq
MIRT1993931	hsa-miR-23c	CLIP-seq
MIRT1993932	hsa-miR-2682	CLIP-seq
MIRT1993933	hsa-miR-27a	CLIP-seq
MIRT1993934	hsa-miR-27b	CLIP-seq
MIRT1993935	hsa-miR-299-3p	CLIP-seq
MIRT1993936	hsa-miR-301a	CLIP-seq
MIRT1993937	hsa-miR-301b	CLIP-seq
MIRT1993938	hsa-miR-34a	CLIP-seq
MIRT1993939	hsa-miR-34c-5p	CLIP-seq
MIRT1993940	hsa-miR-3666	CLIP-seq
MIRT1993941	hsa-miR-4260	CLIP-seq
MIRT1993942	hsa-miR-4269	CLIP-seq
MIRT1993943	hsa-miR-4295	CLIP-seq
MIRT1993944	hsa-miR-4436a	CLIP-seq
MIRT1993945	hsa-miR-4491	CLIP-seq
MIRT1993946	hsa-miR-449a	CLIP-seq
MIRT1993947	hsa-miR-449b	CLIP-seq
MIRT1993948	hsa-miR-449c	CLIP-seq
MIRT1993949	hsa-miR-4514	CLIP-seq
MIRT1993950	hsa-miR-454	CLIP-seq
MIRT1993951	hsa-miR-4657	CLIP-seq
MIRT1993952	hsa-miR-4687-5p	CLIP-seq
MIRT1993953	hsa-miR-4691-3p	CLIP-seq
MIRT1993954	hsa-miR-4692	CLIP-seq
MIRT1993955	hsa-miR-4712-5p	CLIP-seq
MIRT1993956	hsa-miR-4742-5p	CLIP-seq
MIRT1993957	hsa-miR-4755-3p	CLIP-seq
MIRT1993958	hsa-miR-513a-5p	CLIP-seq
MIRT1993959	hsa-miR-518a-5p	CLIP-seq
MIRT1993960	hsa-miR-519a	CLIP-seq
MIRT1993961	hsa-miR-519b-3p	CLIP-seq
MIRT1993962	hsa-miR-519c-3p	CLIP-seq
MIRT1993963	hsa-miR-520a-5p	CLIP-seq
MIRT1993964	hsa-miR-525-5p	CLIP-seq
MIRT1993965	hsa-miR-527	CLIP-seq
MIRT1993966	hsa-miR-589	CLIP-seq
MIRT1993967	hsa-miR-615-5p	CLIP-seq
MIRT1993968	hsa-miR-659	CLIP-seq
MIRT1993969	hsa-miR-665	CLIP-seq
MIRT1993970	hsa-miR-770-5p	CLIP-seq
MIRT2227957	hsa-miR-101	CLIP-seq
MIRT2227958	hsa-miR-128	CLIP-seq
MIRT2227959	hsa-miR-1302	CLIP-seq
MIRT1993933	hsa-miR-27a	CLIP-seq
MIRT1993934	hsa-miR-27b	CLIP-seq
MIRT2227960	hsa-miR-3122	CLIP-seq
MIRT2227961	hsa-miR-3199	CLIP-seq
MIRT2227962	hsa-miR-3691-3p	CLIP-seq
MIRT2227963	hsa-miR-3913-5p	CLIP-seq
MIRT1993942	hsa-miR-4269	CLIP-seq
MIRT2227964	hsa-miR-4298	CLIP-seq
MIRT991211	hsa-miR-4310	CLIP-seq
MIRT2227965	hsa-miR-4480	CLIP-seq
MIRT1993949	hsa-miR-4514	CLIP-seq
MIRT2227966	hsa-miR-4520a-3p	CLIP-seq
MIRT2227967	hsa-miR-4520b-3p	CLIP-seq
MIRT1993954	hsa-miR-4692	CLIP-seq
MIRT1993956	hsa-miR-4742-5p	CLIP-seq
MIRT2227968	hsa-miR-500a	CLIP-seq
MIRT1993958	hsa-miR-513a-5p	CLIP-seq
MIRT1993960	hsa-miR-519a	CLIP-seq
MIRT1993961	hsa-miR-519b-3p	CLIP-seq
MIRT1993962	hsa-miR-519c-3p	CLIP-seq
MIRT2227969	hsa-miR-890	CLIP-seq
MIRT2387924	hsa-miR-409-5p	CLIP-seq
MIRT2387925	hsa-miR-452	CLIP-seq
MIRT2387926	hsa-miR-4676-3p	CLIP-seq
MIRT2387927	hsa-miR-4693-5p	CLIP-seq
MIRT1993958	hsa-miR-513a-5p	CLIP-seq
MIRT1993932	hsa-miR-2682	CLIP-seq
MIRT2428852	hsa-miR-3692	CLIP-seq
MIRT1993942	hsa-miR-4269	CLIP-seq
MIRT1993948	hsa-miR-449c	CLIP-seq
MIRT1993949	hsa-miR-4514	CLIP-seq
MIRT1993954	hsa-miR-4692	CLIP-seq
MIRT1993956	hsa-miR-4742-5p	CLIP-seq
MIRT1993925	hsa-miR-130a	CLIP-seq
MIRT1993926	hsa-miR-130b	CLIP-seq
MIRT1993927	hsa-miR-19a	CLIP-seq
MIRT1993928	hsa-miR-19b	CLIP-seq
MIRT1993929	hsa-miR-23a	CLIP-seq
MIRT1993930	hsa-miR-23b	CLIP-seq
MIRT1993931	hsa-miR-23c	CLIP-seq
MIRT1993936	hsa-miR-301a	CLIP-seq
MIRT1993937	hsa-miR-301b	CLIP-seq
MIRT1993940	hsa-miR-3666	CLIP-seq
MIRT1993941	hsa-miR-4260	CLIP-seq
MIRT1993943	hsa-miR-4295	CLIP-seq
MIRT1993950	hsa-miR-454	CLIP-seq
MIRT1993957	hsa-miR-4755-3p	CLIP-seq
MIRT1993959	hsa-miR-518a-5p	CLIP-seq
MIRT1993960	hsa-miR-519a	CLIP-seq
MIRT1993961	hsa-miR-519b-3p	CLIP-seq
MIRT1993962	hsa-miR-519c-3p	CLIP-seq
MIRT1993965	hsa-miR-527	CLIP-seq
MIRT2531479	hsa-miR-1266	CLIP-seq
MIRT2531480	hsa-miR-1276	CLIP-seq
MIRT1993925	hsa-miR-130a	CLIP-seq
MIRT1993926	hsa-miR-130b	CLIP-seq
MIRT2531481	hsa-miR-149	CLIP-seq
MIRT2531482	hsa-miR-1825	CLIP-seq
MIRT2531483	hsa-miR-199a-5p	CLIP-seq
MIRT2531484	hsa-miR-199b-5p	CLIP-seq
MIRT1993927	hsa-miR-19a	CLIP-seq
MIRT1993928	hsa-miR-19b	CLIP-seq
MIRT2531485	hsa-miR-2117	CLIP-seq
MIRT1993929	hsa-miR-23a	CLIP-seq
MIRT1993930	hsa-miR-23b	CLIP-seq
MIRT1993931	hsa-miR-23c	CLIP-seq
MIRT1993936	hsa-miR-301a	CLIP-seq
MIRT1993937	hsa-miR-301b	CLIP-seq
MIRT2531486	hsa-miR-3130-5p	CLIP-seq
MIRT2531487	hsa-miR-3664-3p	CLIP-seq
MIRT1993940	hsa-miR-3666	CLIP-seq
MIRT2531488	hsa-miR-4255	CLIP-seq
MIRT1993941	hsa-miR-4260	CLIP-seq
MIRT2531489	hsa-miR-4268	CLIP-seq
MIRT2531490	hsa-miR-4270	CLIP-seq
MIRT2531491	hsa-miR-4273	CLIP-seq
MIRT1993943	hsa-miR-4295	CLIP-seq
MIRT2531492	hsa-miR-4441	CLIP-seq
MIRT2531493	hsa-miR-4448	CLIP-seq
MIRT2531494	hsa-miR-4469	CLIP-seq
MIRT2531495	hsa-miR-4482	CLIP-seq
MIRT2531496	hsa-miR-4518	CLIP-seq
MIRT1993950	hsa-miR-454	CLIP-seq
MIRT1993955	hsa-miR-4712-5p	CLIP-seq
MIRT1993957	hsa-miR-4755-3p	CLIP-seq
MIRT1993959	hsa-miR-518a-5p	CLIP-seq
MIRT1993960	hsa-miR-519a	CLIP-seq
MIRT1993961	hsa-miR-519b-3p	CLIP-seq
MIRT1993962	hsa-miR-519c-3p	CLIP-seq
MIRT1993965	hsa-miR-527	CLIP-seq
MIRT2531497	hsa-miR-581	CLIP-seq
MIRT1993966	hsa-miR-589	CLIP-seq
MIRT2531498	hsa-miR-765	CLIP-seq
MIRT1993970	hsa-miR-770-5p	CLIP-seq
MIRT2680869	hsa-miR-1226	CLIP-seq
MIRT2680870	hsa-miR-125b	CLIP-seq
MIRT2531480	hsa-miR-1276	CLIP-seq
MIRT1993925	hsa-miR-130a	CLIP-seq
MIRT1993926	hsa-miR-130b	CLIP-seq
MIRT2680871	hsa-miR-188-5p	CLIP-seq
MIRT1993927	hsa-miR-19a	CLIP-seq
MIRT1993928	hsa-miR-19b	CLIP-seq
MIRT1993929	hsa-miR-23a	CLIP-seq
MIRT1993930	hsa-miR-23b	CLIP-seq
MIRT1993931	hsa-miR-23c	CLIP-seq
MIRT1993936	hsa-miR-301a	CLIP-seq
MIRT1993937	hsa-miR-301b	CLIP-seq
MIRT1993940	hsa-miR-3666	CLIP-seq
MIRT1993941	hsa-miR-4260	CLIP-seq
MIRT2680872	hsa-miR-4261	CLIP-seq
MIRT2680873	hsa-miR-4287	CLIP-seq
MIRT1993943	hsa-miR-4295	CLIP-seq
MIRT2680874	hsa-miR-4319	CLIP-seq
MIRT2531494	hsa-miR-4469	CLIP-seq
MIRT1993950	hsa-miR-454	CLIP-seq
MIRT2680875	hsa-miR-4685-3p	CLIP-seq
MIRT2680876	hsa-miR-4713-5p	CLIP-seq
MIRT2680877	hsa-miR-4732-3p	CLIP-seq
MIRT1993957	hsa-miR-4755-3p	CLIP-seq
MIRT1993959	hsa-miR-518a-5p	CLIP-seq
MIRT1993960	hsa-miR-519a	CLIP-seq
MIRT1993961	hsa-miR-519b-3p	CLIP-seq
MIRT1993962	hsa-miR-519c-3p	CLIP-seq
MIRT1993965	hsa-miR-527	CLIP-seq
MIRT2680878	hsa-miR-670	CLIP-seq
MIRT2531498	hsa-miR-765	CLIP-seq

Gene ontology (GO) Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	NAS	10531035, 10531037
GO:0004842	Function	Ubiquitin-protein transferase activity	NAS	10531035, 10531037
GO:0005515	Function	Protein binding	IPI	23431138
GO:0005737	Component	Cytoplasm	IDA	23431138
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IMP	23431138
GO:0006915	Process	Apoptotic process	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016567	Process	Protein ubiquitination	NAS	10531035, 10531037
GO:0042981	Process	Regulation of apoptotic process	IBA
GO:0042981	Process	Regulation of apoptotic process	IMP	23431138

Other IDs

• MIM: 609092
• HGNC: 13589
• e!Ensembl: ENSG00000147912

Protein

• UniProt ID: Q9UK96
• Protein name: F-box only protein 10
• Protein function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stabilit
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00646	F-box	5 → 48	F-box domain	Domain
  PF05048	NosD	702 → 893	Periplasmic copper-binding protein (NosD)	Domain
  PF13229	Beta_helix	420 → 573	Right handed beta helix region	Family
  PF13229	Beta_helix	563 → 695	Right handed beta helix region	Family

• Sequence:

  MEAGGLPLELWRMILAYLHLPDLGRCSLVCRAWYELILSLDSTRWRQLCLGCTECRHPNW
  PNQPDVEPESWREAFKQHYLASKTWTKNALDLESSICFSLFRRRRERRTLSVGPGREFDS
  LGSALAMASLYDRIVLFPGVYEEQGEIILKVPVEIVGQGKLGEVALLASIDQHCSTTRLC
  NLVFTPAWFSPIMYKTTSGHVQFDNCNFENGHIQVHGPGTCQVKFCTFKNTHIFLHNVPL
  CVLENCEFVGSENNSVTVEGHPSADKNWAYKYLLGLIKSSPTFLPTEDSDFLMSLDLESR
  DQAWSPKTCDIVIEGSQSPTSPASSSPKPGSKAGSQEAEVGSDGERVAQTPDSSDGGLSP
  SGEDEDEDQLMYRLSYQVQGPRPVLGGSFLGPPLPGASIQLPSCLVLNSLQQELQKDKEA
  MALANSVQGCLIRKCLFRDGKGGVFVCSHGRAKMEGNIFRNLTYAVRCIHNSKIIMLRND
  IYRCRASGIFLRLEGGGLIAGNNIYHNAEAGVDIRKKSNPLILCNQIHHGLRSGIVVLGN
  GKGIIRNNQIFSNKEAGIYILYHGNPVVSGNHIFKGRAAGIAVNENGKGLITENVIRENQ
  WGGVDIRRGGIPVLRSNLICFGYSDGVVVGDEGKGLIEGNTIYANKGCGVWMMSSSLPHV
  TSNHVSYNGLYGVAVFSQKDGSSELPRGHRAQENFSEDGDAILWETELEKEDDPLRRPIT
  IALVESNSINHNGASGLYVQSSEALHVITNVIHANGDRGITVAQSSQPTRVANNSISCNR
  QSGVKVEAQCKVELRGNGIYDNRGHGIITKGDSTIVIENDIIGNRGSGLQLLPRSDTKVI
  KNRIHSFRAYGIAVRGRAKALVQENIIFQGKTSKTIFQQISNNRECIMQNNKFLVFKKKS
  DTWRLVNPPARPHLENSLRRPSAAHNGQKVTAMATRITARVEGGYHSNRSVFCTIL

• Sequence length: 956

Pathways

Reactome Pathway

Neddylation

Antigen processing: Ubiquitination & Proteasome degradation

Related Genes

No strongly related genes found yet for FBXO10.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to FBXO10.