FBXL22 (F-box and leucine rich repeat protein 22)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 283807
• Gene name: F-box and leucine rich repeat protein 22
• Gene symbol: FBXL22
• Synonyms (NCBI Gene): Fbl22
• Chromosome: 15
• Chromosome location: 15q22.31
• Summary: This gene encodes a member of the F-box protein family. This F-box protein interacts with S-phase kinase-associated protein 1A and cullin in order to form SCF complexes which function as ubiquitin ligases.[provided by RefSeq, Sep 2010]

miRNA Show/Hide all (75)

miRTarBase ID	miRNA	Experiments	Reference
MIRT990998	hsa-miR-1304	CLIP-seq
MIRT990999	hsa-miR-138	CLIP-seq
MIRT991000	hsa-miR-146a	CLIP-seq
MIRT991001	hsa-miR-146b-5p	CLIP-seq
MIRT991002	hsa-miR-2467-5p	CLIP-seq
MIRT991003	hsa-miR-3119	CLIP-seq
MIRT991004	hsa-miR-3154	CLIP-seq
MIRT991005	hsa-miR-3158-3p	CLIP-seq
MIRT991006	hsa-miR-3176	CLIP-seq
MIRT991007	hsa-miR-3188	CLIP-seq
MIRT991008	hsa-miR-3192	CLIP-seq
MIRT991009	hsa-miR-3689a-3p	CLIP-seq
MIRT991010	hsa-miR-3689c	CLIP-seq
MIRT991011	hsa-miR-3922-3p	CLIP-seq
MIRT991012	hsa-miR-3975	CLIP-seq
MIRT991013	hsa-miR-433	CLIP-seq
MIRT991014	hsa-miR-4446-3p	CLIP-seq
MIRT991015	hsa-miR-4659a-3p	CLIP-seq
MIRT991016	hsa-miR-4659b-3p	CLIP-seq
MIRT991017	hsa-miR-4662a-5p	CLIP-seq
MIRT991018	hsa-miR-4676-5p	CLIP-seq
MIRT991019	hsa-miR-4685-5p	CLIP-seq
MIRT991020	hsa-miR-4728-5p	CLIP-seq
MIRT991021	hsa-miR-485-5p	CLIP-seq
MIRT991022	hsa-miR-548ag	CLIP-seq
MIRT991023	hsa-miR-548ai	CLIP-seq
MIRT991024	hsa-miR-575	CLIP-seq
MIRT991025	hsa-miR-589	CLIP-seq
MIRT991026	hsa-miR-661	CLIP-seq
MIRT1993876	hsa-miR-106a	CLIP-seq
MIRT1993877	hsa-miR-106b	CLIP-seq
MIRT1993878	hsa-miR-1236	CLIP-seq
MIRT1993879	hsa-miR-17	CLIP-seq
MIRT1993880	hsa-miR-20a	CLIP-seq
MIRT1993881	hsa-miR-20b	CLIP-seq
MIRT1993882	hsa-miR-3609	CLIP-seq
MIRT1993883	hsa-miR-4757-5p	CLIP-seq
MIRT1993884	hsa-miR-4796-3p	CLIP-seq
MIRT1993885	hsa-miR-519d	CLIP-seq
MIRT1993886	hsa-miR-548ah	CLIP-seq
MIRT1993887	hsa-miR-93	CLIP-seq
MIRT1993876	hsa-miR-106a	CLIP-seq
MIRT1993877	hsa-miR-106b	CLIP-seq
MIRT2227886	hsa-miR-1193	CLIP-seq
MIRT2227887	hsa-miR-1256	CLIP-seq
MIRT1993879	hsa-miR-17	CLIP-seq
MIRT1993880	hsa-miR-20a	CLIP-seq
MIRT1993881	hsa-miR-20b	CLIP-seq
MIRT2227888	hsa-miR-2392	CLIP-seq
MIRT2227889	hsa-miR-302a	CLIP-seq
MIRT2227890	hsa-miR-302b	CLIP-seq
MIRT2227891	hsa-miR-302c	CLIP-seq
MIRT2227892	hsa-miR-302d	CLIP-seq
MIRT2227893	hsa-miR-302e	CLIP-seq
MIRT1993882	hsa-miR-3609	CLIP-seq
MIRT2227894	hsa-miR-372	CLIP-seq
MIRT2227895	hsa-miR-373	CLIP-seq
MIRT2227896	hsa-miR-4438	CLIP-seq
MIRT991017	hsa-miR-4662a-5p	CLIP-seq
MIRT991018	hsa-miR-4676-5p	CLIP-seq
MIRT2227897	hsa-miR-4731-5p	CLIP-seq
MIRT1993883	hsa-miR-4757-5p	CLIP-seq
MIRT1993884	hsa-miR-4796-3p	CLIP-seq
MIRT2227898	hsa-miR-5095	CLIP-seq
MIRT2227899	hsa-miR-5096	CLIP-seq
MIRT2227900	hsa-miR-512-3p	CLIP-seq
MIRT1993885	hsa-miR-519d	CLIP-seq
MIRT2227901	hsa-miR-520a-3p	CLIP-seq
MIRT2227902	hsa-miR-520b	CLIP-seq
MIRT2227903	hsa-miR-520c-3p	CLIP-seq
MIRT2227904	hsa-miR-520d-3p	CLIP-seq
MIRT2227905	hsa-miR-520e	CLIP-seq
MIRT1993886	hsa-miR-548ah	CLIP-seq
MIRT991024	hsa-miR-575	CLIP-seq
MIRT1993887	hsa-miR-93	CLIP-seq

Gene ontology (GO) Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	22972877, 32296183, 33961781
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0016567	Process	Protein ubiquitination	IEA
GO:0030018	Component	Z disc	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	22972877
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	22972877

Other IDs

• MIM: 609088
• HGNC: 27537
• e!Ensembl: ENSG00000197361

Protein

• UniProt ID: Q6P050
• Protein name: F-box and leucine-rich protein 22
• Protein function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12937	F-box-like	12 → 55	F-box-like	Domain

• Tissue specificity: TISSUE SPECIFICITY: Enriched in cardiac muscle. {ECO:0000269|PubMed:22972877}.
• Sequence:

  MWPLLTMHITQLNRECLLHLFSFLDKDSRKSLARTCSQLHDVFEDPALWSLLHFRSLTEL
  QKDNFLLGPALRSLSICWHSSRVQVCSIEDWLKSAFQRSICSRHESLVNDFLLRVCDRLS
  AVRSPRRREAPAPSSGTPIAVGPKSPRWGGPDHSEFADLRSGVTGARAAARRGLGSLRAE
  RPSETPPAPGVSWGPPPPGAPVVISVKQEEGKQGRTGRRSHRAAPPCGFARTRVCPPTFP
  GADAFPQ

• Sequence length: 247

Pathways

Reactome Pathway

Neddylation

Antigen processing: Ubiquitination & Proteasome degradation

Related Genes

No strongly related genes found yet for FBXL22.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to FBXL22.