FBXL15 (F-box and leucine rich repeat protein 15)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 79176
• Gene name: F-box and leucine rich repeat protein 15
• Gene symbol: FBXL15
• Synonyms (NCBI Gene): FBXO37, Fbl15, JET, PSD
• Chromosome: 10
• Chromosome location: 10q24.32

miRNA Show/Hide all (44)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048418	hsa-miR-100-5p	CLASH	23622248
MIRT1993529	hsa-miR-1207-5p	CLIP-seq
MIRT1993530	hsa-miR-1226	CLIP-seq
MIRT1993531	hsa-miR-1229	CLIP-seq
MIRT1993532	hsa-miR-128	CLIP-seq
MIRT1993533	hsa-miR-193a-3p	CLIP-seq
MIRT1993534	hsa-miR-193b	CLIP-seq
MIRT1993535	hsa-miR-27a	CLIP-seq
MIRT1993536	hsa-miR-27b	CLIP-seq
MIRT1993537	hsa-miR-3162-3p	CLIP-seq
MIRT1993538	hsa-miR-3176	CLIP-seq
MIRT1993539	hsa-miR-3922-3p	CLIP-seq
MIRT1993540	hsa-miR-4257	CLIP-seq
MIRT1993541	hsa-miR-4302	CLIP-seq
MIRT1993542	hsa-miR-4328	CLIP-seq
MIRT1993543	hsa-miR-4446-5p	CLIP-seq
MIRT1993544	hsa-miR-4733-3p	CLIP-seq
MIRT1993545	hsa-miR-4755-5p	CLIP-seq
MIRT1993546	hsa-miR-4757-5p	CLIP-seq
MIRT1993547	hsa-miR-4763-3p	CLIP-seq
MIRT1993529	hsa-miR-1207-5p	CLIP-seq
MIRT1993530	hsa-miR-1226	CLIP-seq
MIRT1993531	hsa-miR-1229	CLIP-seq
MIRT1993532	hsa-miR-128	CLIP-seq
MIRT1993533	hsa-miR-193a-3p	CLIP-seq
MIRT1993534	hsa-miR-193b	CLIP-seq
MIRT2227352	hsa-miR-1972	CLIP-seq
MIRT1993535	hsa-miR-27a	CLIP-seq
MIRT1993536	hsa-miR-27b	CLIP-seq
MIRT2227353	hsa-miR-3151	CLIP-seq
MIRT1993537	hsa-miR-3162-3p	CLIP-seq
MIRT1993538	hsa-miR-3176	CLIP-seq
MIRT1993539	hsa-miR-3922-3p	CLIP-seq
MIRT1993540	hsa-miR-4257	CLIP-seq
MIRT1993541	hsa-miR-4302	CLIP-seq
MIRT1993542	hsa-miR-4328	CLIP-seq
MIRT1993543	hsa-miR-4446-5p	CLIP-seq
MIRT2227354	hsa-miR-4650-5p	CLIP-seq
MIRT2227355	hsa-miR-4685-5p	CLIP-seq
MIRT1993544	hsa-miR-4733-3p	CLIP-seq
MIRT1993545	hsa-miR-4755-5p	CLIP-seq
MIRT1993546	hsa-miR-4757-5p	CLIP-seq
MIRT1993547	hsa-miR-4763-3p	CLIP-seq
MIRT2227356	hsa-miR-486-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000086	Process	G2/M transition of mitotic cell cycle	IMP	21572392
GO:0005515	Function	Protein binding	IPI	21572392
GO:0005737	Component	Cytoplasm	IDA	21572392
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0009953	Process	Dorsal/ventral pattern formation	ISS
GO:0016567	Process	Protein ubiquitination	IDA	21572392
GO:0016567	Process	Protein ubiquitination	IEA
GO:0019005	Component	SCF ubiquitin ligase complex	IBA
GO:0019005	Component	SCF ubiquitin ligase complex	IDA	21572392
GO:0030282	Process	Bone mineralization	IEA
GO:0030282	Process	Bone mineralization	ISS
GO:0030513	Process	Positive regulation of BMP signaling pathway	IMP	21572392
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA	21572392

Other IDs

• MIM: 610287
• HGNC: 28155
• e!Ensembl: ENSG00000107872

Protein

• UniProt ID: Q9H469
• Protein name: F-box/LRR-repeat protein 15 (F-box only protein 37)
• Protein function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signalin
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00646	F-box	18 → 61	F-box domain	Domain
  PF13516	LRR_6	217 → 241	Leucine Rich repeat	Repeat

• Sequence:

  MEPPMEPSGGEQEPGAVRFLDLPWEDVLLPHVLNRVPLRQLLRLQRVSRAFRSLVQLHLA
  GLRRFDAAQVGPQIPRAALARLLRDAEGLQELALAPCHEWLSDEDLVPVLARNPQLRSVA
  LGGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRGLADRCPALEELDLTACRQLK
  DEAIVYLAQRRGAGLRSLSLAVNANVGDAAVQELARNCPELHHLDLTGCLRVGSDGVRTL
  AEYCPVLRSLRVRHCHHVAESSLSRLRKRGVDIDVEPPLHQALVLLQDMAGFAPFVNLQV
  

• Sequence length: 300

Pathways

Reactome Pathway

Neddylation

Antigen processing: Ubiquitination & Proteasome degradation

Related Genes

No strongly related genes found yet for FBXL15.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to FBXL15.