FBXL12 (F-box and leucine rich repeat protein 12)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 54850
• Gene name: F-box and leucine rich repeat protein 12
• Gene symbol: FBXL12
• Synonyms (NCBI Gene): Fbl12
• Chromosome: 19
• Chromosome location: 19p13.2
• Summary: Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box pr

miRNA Show/Hide all (103)

miRTarBase ID	miRNA	Experiments	Reference
MIRT990218	hsa-let-7a	CLIP-seq
MIRT990219	hsa-let-7b	CLIP-seq
MIRT990220	hsa-let-7c	CLIP-seq
MIRT990221	hsa-let-7d	CLIP-seq
MIRT990222	hsa-let-7e	CLIP-seq
MIRT990223	hsa-let-7f	CLIP-seq
MIRT990224	hsa-let-7g	CLIP-seq
MIRT990225	hsa-let-7i	CLIP-seq
MIRT990226	hsa-miR-1294	CLIP-seq
MIRT990227	hsa-miR-202	CLIP-seq
MIRT990228	hsa-miR-3180-5p	CLIP-seq
MIRT990229	hsa-miR-3663-3p	CLIP-seq
MIRT990230	hsa-miR-4458	CLIP-seq
MIRT990231	hsa-miR-4500	CLIP-seq
MIRT990232	hsa-miR-451	CLIP-seq
MIRT990233	hsa-miR-4793-5p	CLIP-seq
MIRT990234	hsa-miR-520a-5p	CLIP-seq
MIRT990235	hsa-miR-525-5p	CLIP-seq
MIRT990236	hsa-miR-556-5p	CLIP-seq
MIRT990237	hsa-miR-98	CLIP-seq
MIRT1993515	hsa-miR-4283	CLIP-seq
MIRT990229	hsa-miR-3663-3p	CLIP-seq
MIRT990236	hsa-miR-556-5p	CLIP-seq
MIRT2387906	hsa-miR-1182	CLIP-seq
MIRT2387907	hsa-miR-4257	CLIP-seq
MIRT990229	hsa-miR-3663-3p	CLIP-seq
MIRT990218	hsa-let-7a	CLIP-seq
MIRT990219	hsa-let-7b	CLIP-seq
MIRT990220	hsa-let-7c	CLIP-seq
MIRT990221	hsa-let-7d	CLIP-seq
MIRT990222	hsa-let-7e	CLIP-seq
MIRT990223	hsa-let-7f	CLIP-seq
MIRT990224	hsa-let-7g	CLIP-seq
MIRT990225	hsa-let-7i	CLIP-seq
MIRT2531295	hsa-miR-1292	CLIP-seq
MIRT990226	hsa-miR-1294	CLIP-seq
MIRT2531296	hsa-miR-1303	CLIP-seq
MIRT990227	hsa-miR-202	CLIP-seq
MIRT2531297	hsa-miR-299-3p	CLIP-seq
MIRT990228	hsa-miR-3180-5p	CLIP-seq
MIRT2531298	hsa-miR-3192	CLIP-seq
MIRT2531299	hsa-miR-3612	CLIP-seq
MIRT2531300	hsa-miR-4300	CLIP-seq
MIRT2531301	hsa-miR-4443	CLIP-seq
MIRT990230	hsa-miR-4458	CLIP-seq
MIRT2531302	hsa-miR-4461	CLIP-seq
MIRT2531303	hsa-miR-4471	CLIP-seq
MIRT990231	hsa-miR-4500	CLIP-seq
MIRT2531304	hsa-miR-4505	CLIP-seq
MIRT2531305	hsa-miR-450b-5p	CLIP-seq
MIRT990232	hsa-miR-451	CLIP-seq
MIRT2531306	hsa-miR-4522	CLIP-seq
MIRT2531307	hsa-miR-4648	CLIP-seq
MIRT2531308	hsa-miR-4654	CLIP-seq
MIRT2531309	hsa-miR-4769-5p	CLIP-seq
MIRT990233	hsa-miR-4793-5p	CLIP-seq
MIRT2531310	hsa-miR-485-5p	CLIP-seq
MIRT2531311	hsa-miR-516b	CLIP-seq
MIRT990234	hsa-miR-520a-5p	CLIP-seq
MIRT990235	hsa-miR-525-5p	CLIP-seq
MIRT2531312	hsa-miR-576-3p	CLIP-seq
MIRT2531313	hsa-miR-650	CLIP-seq
MIRT2531314	hsa-miR-920	CLIP-seq
MIRT990237	hsa-miR-98	CLIP-seq
MIRT990218	hsa-let-7a	CLIP-seq
MIRT990219	hsa-let-7b	CLIP-seq
MIRT990220	hsa-let-7c	CLIP-seq
MIRT990221	hsa-let-7d	CLIP-seq
MIRT990222	hsa-let-7e	CLIP-seq
MIRT990223	hsa-let-7f	CLIP-seq
MIRT990224	hsa-let-7g	CLIP-seq
MIRT990225	hsa-let-7i	CLIP-seq
MIRT2531295	hsa-miR-1292	CLIP-seq
MIRT990226	hsa-miR-1294	CLIP-seq
MIRT2531296	hsa-miR-1303	CLIP-seq
MIRT990227	hsa-miR-202	CLIP-seq
MIRT2531297	hsa-miR-299-3p	CLIP-seq
MIRT990228	hsa-miR-3180-5p	CLIP-seq
MIRT2531298	hsa-miR-3192	CLIP-seq
MIRT2531299	hsa-miR-3612	CLIP-seq
MIRT2531300	hsa-miR-4300	CLIP-seq
MIRT2531301	hsa-miR-4443	CLIP-seq
MIRT990230	hsa-miR-4458	CLIP-seq
MIRT2531302	hsa-miR-4461	CLIP-seq
MIRT2531303	hsa-miR-4471	CLIP-seq
MIRT990231	hsa-miR-4500	CLIP-seq
MIRT2531304	hsa-miR-4505	CLIP-seq
MIRT2531305	hsa-miR-450b-5p	CLIP-seq
MIRT990232	hsa-miR-451	CLIP-seq
MIRT2531306	hsa-miR-4522	CLIP-seq
MIRT2531307	hsa-miR-4648	CLIP-seq
MIRT2531308	hsa-miR-4654	CLIP-seq
MIRT2531309	hsa-miR-4769-5p	CLIP-seq
MIRT990233	hsa-miR-4793-5p	CLIP-seq
MIRT2531310	hsa-miR-485-5p	CLIP-seq
MIRT2531311	hsa-miR-516b	CLIP-seq
MIRT990234	hsa-miR-520a-5p	CLIP-seq
MIRT990235	hsa-miR-525-5p	CLIP-seq
MIRT2531312	hsa-miR-576-3p	CLIP-seq
MIRT2680837	hsa-miR-645	CLIP-seq
MIRT2531313	hsa-miR-650	CLIP-seq
MIRT2531314	hsa-miR-920	CLIP-seq
MIRT990237	hsa-miR-98	CLIP-seq

Gene ontology (GO) Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	IEA
GO:0005515	Function	Protein binding	IPI	18660753, 21163940, 25416956, 27705803, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0016567	Process	Protein ubiquitination	IEA

Other IDs

• MIM: 609079
• HGNC: 13611
• e!Ensembl: ENSG00000127452

Protein

• UniProt ID: Q9NXK8
• Protein name: F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12)
• Protein function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12937	F-box-like	4 → 50	F-box-like	Domain

• Sequence:

  MATLVELPDSVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLYTMRPKVMW
  HLLRRYMASRLHSLRMGGYLFSGSQAPQLSPALLRALGQKCPNLKRLCLHVADLSMVPIT
  SLPSTLRTLELHSCEISMAWLHKQQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRS
  LVLGGTYRVTETGLDAGLQELSYLQRLEVLGCTLSADSTLLAISRHLRDVRKIRLTVRGL
  SAPGLAVLEGMPALESLCLQGPLVTPEMPSPTEILSSCLTMPKLRVLELQGLGWEGQEAE
  KILCKGLPHCMVIVRACPKESMDWWM

• Sequence length: 326

Pathways

Reactome Pathway

Neddylation

Antigen processing: Ubiquitination & Proteasome degradation

Related Genes

No strongly related genes found yet for FBXL12.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to FBXL12.