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Gene Gene information from NCBI Gene database.
Entrez ID 130074
Gene name Family with sequence similarity 168 member B
Gene symbol FAM168B
Synonyms (NCBI Gene)
MANI
Chromosome 2
Chromosome location 2q21.1
miRNA miRNA information provided by mirtarbase database.
1099 Show/Hide all (1099)
miRTarBase ID miRNA Experiments Reference
MIRT029136 hsa-miR-26b-5p Microarray 19088304
MIRT049312 hsa-miR-92a-3p CLASH 23622248
MIRT046272 hsa-miR-23b-3p CLASH 23622248
MIRT043832 hsa-miR-330-3p CLASH 23622248
MIRT043304 hsa-miR-331-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8 Show/Hide all (8)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183, 32814053
GO:0005737 Component Cytoplasm IEA
GO:0005886 Component Plasma membrane IEA
GO:0016020 Component Membrane IEA
GO:0030424 Component Axon IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
620078 27016 ENSG00000152102
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
A1KXE4
Protein name Myelin-associated neurite-outgrowth inhibitor (Mani) (p20)
Protein function Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14944 TCRP1 51 → 195 Tongue Cancer Chemotherapy Resistant Protein 1 Family
PF14944 TCRP1 1 → 52 Tongue Cancer Chemotherapy Resistant Protein 1 Family
Tissue specificity TISSUE SPECIFICITY: Expressed in the brain, within neuronal axonal fibers and associated with myelin sheets (at protein level). Expression tends to be lower in the brain of Alzheimer disease patients compared to healthy individuals (at protein level). {EC
Sequence
MNPVYSPGSSGVPYANAKGIGYPAGFPMGYAAAAPAYSPNMYPGANPTFQTGYTPGTPYK
VSCSPTSGAVPPYSSSPNPYQTAVYPVRSAYPQQSPYAQQGTYYTQPLYAAPPHVIHHTT
VVQPNGMPATVYPAPIPPPRGNGVTMGMVAGTTMAMSAGTLLTAHSPTPVAPHPVTVPTY
RAPGTPTYSYVPPQW
Sequence length 195
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Myoepithelial tumor Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (9)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Becker Muscular Dystrophy Becker Muscular Dystrophy BEFREE 2900805
★★★★★
★☆☆☆☆
Found in Text Mining only
Fibrosis, Liver Liver Fibrosis BEFREE 31301646
★★★★★
★☆☆☆☆
Found in Text Mining only
Glioma Glioma BEFREE 21150246
★★★★★
★☆☆☆☆
Found in Text Mining only
Hypoalbuminemia Hypoalbuminemia BEFREE 31067355
★★★★★
★☆☆☆☆
Found in Text Mining only
Muscular Dystrophy, Duchenne Duchenne Muscular Dystrophy BEFREE 1709287, 2900805
★★★★★
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 28547860
★★★★★
★☆☆☆☆
Found in Text Mining only
Neurodegenerative Disorders Neurodegenerative Disorders BEFREE 20716133, 23817205
★★★★★
★☆☆☆☆
Found in Text Mining only
Neuropsychiatric Systemic Lupus Erythematosus Neuropsychiatric Systemic Lupus Erythematosus BEFREE 28807492
★★★★★
★☆☆☆☆
Found in Text Mining only
Steatohepatitis Fatty Liver BEFREE 29735977
★★★★★
★☆☆☆☆
Found in Text Mining only