FAM120C (family with sequence similarity 120 member C)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Diseases linked via similar genes

Gene

• Entrez ID: 54954
• Gene name: Family with sequence similarity 120 member C
• Gene symbol: FAM120C
• Synonyms (NCBI Gene): CXorf17, ORF34
• Chromosome: X
• Chromosome location: Xp11.22
• Summary: This gene encodes a potential transmembrane protein and lies in a region where mutations and deletions have been associated with intellectual disability and autism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 201

miRNA Show/Hide all (211)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021696	hsa-miR-133a-3p	Microarray	21396852
MIRT031340	hsa-miR-18a-5p	Sequencing	20371350
MIRT978258	hsa-miR-1236	CLIP-seq
MIRT978259	hsa-miR-1276	CLIP-seq
MIRT978260	hsa-miR-15a	CLIP-seq
MIRT978261	hsa-miR-15b	CLIP-seq
MIRT978262	hsa-miR-16	CLIP-seq
MIRT978263	hsa-miR-181a	CLIP-seq
MIRT978264	hsa-miR-181b	CLIP-seq
MIRT978265	hsa-miR-181c	CLIP-seq
MIRT978266	hsa-miR-181d	CLIP-seq
MIRT978267	hsa-miR-1827	CLIP-seq
MIRT978268	hsa-miR-195	CLIP-seq
MIRT978269	hsa-miR-3124-3p	CLIP-seq
MIRT978270	hsa-miR-3152-3p	CLIP-seq
MIRT978271	hsa-miR-3153	CLIP-seq
MIRT978272	hsa-miR-3163	CLIP-seq
MIRT978273	hsa-miR-3190	CLIP-seq
MIRT978274	hsa-miR-3192	CLIP-seq
MIRT978275	hsa-miR-320a	CLIP-seq
MIRT978276	hsa-miR-320b	CLIP-seq
MIRT978277	hsa-miR-320c	CLIP-seq
MIRT978278	hsa-miR-320d	CLIP-seq
MIRT978279	hsa-miR-330-3p	CLIP-seq
MIRT978280	hsa-miR-3607-3p	CLIP-seq
MIRT978281	hsa-miR-361-3p	CLIP-seq
MIRT978282	hsa-miR-3614-5p	CLIP-seq
MIRT978283	hsa-miR-3647-3p	CLIP-seq
MIRT978284	hsa-miR-365	CLIP-seq
MIRT978285	hsa-miR-3686	CLIP-seq
MIRT978286	hsa-miR-377	CLIP-seq
MIRT978287	hsa-miR-3909	CLIP-seq
MIRT978288	hsa-miR-424	CLIP-seq
MIRT978289	hsa-miR-425	CLIP-seq
MIRT978290	hsa-miR-4262	CLIP-seq
MIRT978291	hsa-miR-4274	CLIP-seq
MIRT978292	hsa-miR-4312	CLIP-seq
MIRT978293	hsa-miR-4314	CLIP-seq
MIRT978294	hsa-miR-4426	CLIP-seq
MIRT978295	hsa-miR-4429	CLIP-seq
MIRT978296	hsa-miR-4462	CLIP-seq
MIRT978297	hsa-miR-4477a	CLIP-seq
MIRT978298	hsa-miR-4519	CLIP-seq
MIRT978299	hsa-miR-4534	CLIP-seq
MIRT978300	hsa-miR-4540	CLIP-seq
MIRT978301	hsa-miR-4646-5p	CLIP-seq
MIRT978302	hsa-miR-4647	CLIP-seq
MIRT978303	hsa-miR-4662b	CLIP-seq
MIRT978304	hsa-miR-4666-5p	CLIP-seq
MIRT978305	hsa-miR-4668-5p	CLIP-seq
MIRT978306	hsa-miR-4688	CLIP-seq
MIRT978307	hsa-miR-4712-5p	CLIP-seq
MIRT978308	hsa-miR-4729	CLIP-seq
MIRT978309	hsa-miR-4738-3p	CLIP-seq
MIRT978310	hsa-miR-4762-3p	CLIP-seq
MIRT978311	hsa-miR-4764-3p	CLIP-seq
MIRT978312	hsa-miR-4766-5p	CLIP-seq
MIRT978313	hsa-miR-4768-3p	CLIP-seq
MIRT978314	hsa-miR-4777-3p	CLIP-seq
MIRT978315	hsa-miR-497	CLIP-seq
MIRT978316	hsa-miR-502-5p	CLIP-seq
MIRT978317	hsa-miR-520d-5p	CLIP-seq
MIRT978318	hsa-miR-524-5p	CLIP-seq
MIRT978319	hsa-miR-526b	CLIP-seq
MIRT978320	hsa-miR-532-5p	CLIP-seq
MIRT978321	hsa-miR-548c-3p	CLIP-seq
MIRT978322	hsa-miR-548k	CLIP-seq
MIRT978323	hsa-miR-548n	CLIP-seq
MIRT978324	hsa-miR-548t	CLIP-seq
MIRT978325	hsa-miR-554	CLIP-seq
MIRT978326	hsa-miR-561	CLIP-seq
MIRT978327	hsa-miR-563	CLIP-seq
MIRT978328	hsa-miR-579	CLIP-seq
MIRT978329	hsa-miR-590-3p	CLIP-seq
MIRT978330	hsa-miR-603	CLIP-seq
MIRT978331	hsa-miR-648	CLIP-seq
MIRT978332	hsa-miR-671-5p	CLIP-seq
MIRT978333	hsa-miR-770-5p	CLIP-seq
MIRT978334	hsa-miR-885-5p	CLIP-seq
MIRT978335	hsa-miR-940	CLIP-seq
MIRT978319	hsa-miR-526b	CLIP-seq
MIRT1989932	hsa-let-7a	CLIP-seq
MIRT1989933	hsa-let-7b	CLIP-seq
MIRT1989934	hsa-let-7c	CLIP-seq
MIRT1989935	hsa-let-7d	CLIP-seq
MIRT1989936	hsa-let-7e	CLIP-seq
MIRT1989937	hsa-let-7f	CLIP-seq
MIRT1989938	hsa-let-7g	CLIP-seq
MIRT1989939	hsa-let-7i	CLIP-seq
MIRT1989940	hsa-miR-1208	CLIP-seq
MIRT1989941	hsa-miR-1231	CLIP-seq
MIRT1989942	hsa-miR-1256	CLIP-seq
MIRT1989943	hsa-miR-1285	CLIP-seq
MIRT1989944	hsa-miR-1305	CLIP-seq
MIRT1989945	hsa-miR-137	CLIP-seq
MIRT1989946	hsa-miR-1470	CLIP-seq
MIRT978263	hsa-miR-181a	CLIP-seq
MIRT978264	hsa-miR-181b	CLIP-seq
MIRT978265	hsa-miR-181c	CLIP-seq
MIRT978266	hsa-miR-181d	CLIP-seq
MIRT1989947	hsa-miR-1909	CLIP-seq
MIRT1989948	hsa-miR-297	CLIP-seq
MIRT1989949	hsa-miR-3117-5p	CLIP-seq
MIRT1989950	hsa-miR-3120-5p	CLIP-seq
MIRT1989951	hsa-miR-3140-3p	CLIP-seq
MIRT1989952	hsa-miR-3148	CLIP-seq
MIRT1989953	hsa-miR-3154	CLIP-seq
MIRT1989954	hsa-miR-3179	CLIP-seq
MIRT1989955	hsa-miR-3185	CLIP-seq
MIRT1989956	hsa-miR-3187-5p	CLIP-seq
MIRT1989957	hsa-miR-3202	CLIP-seq
MIRT1989958	hsa-miR-323b-5p	CLIP-seq
MIRT1989959	hsa-miR-329	CLIP-seq
MIRT1989960	hsa-miR-337-3p	CLIP-seq
MIRT1989961	hsa-miR-340	CLIP-seq
MIRT1989962	hsa-miR-362-3p	CLIP-seq
MIRT1989963	hsa-miR-3663-5p	CLIP-seq
MIRT1989964	hsa-miR-3685	CLIP-seq
MIRT978286	hsa-miR-377	CLIP-seq
MIRT1989965	hsa-miR-378g	CLIP-seq
MIRT1989966	hsa-miR-382	CLIP-seq
MIRT1989967	hsa-miR-384	CLIP-seq
MIRT1989968	hsa-miR-3910	CLIP-seq
MIRT1989969	hsa-miR-3922-5p	CLIP-seq
MIRT1989970	hsa-miR-3924	CLIP-seq
MIRT1989971	hsa-miR-3927	CLIP-seq
MIRT1989972	hsa-miR-3935	CLIP-seq
MIRT1989973	hsa-miR-3941	CLIP-seq
MIRT1989974	hsa-miR-4254	CLIP-seq
MIRT978290	hsa-miR-4262	CLIP-seq
MIRT1989975	hsa-miR-4288	CLIP-seq
MIRT1989976	hsa-miR-4289	CLIP-seq
MIRT978293	hsa-miR-4314	CLIP-seq
MIRT978294	hsa-miR-4426	CLIP-seq
MIRT1989977	hsa-miR-4458	CLIP-seq
MIRT1989978	hsa-miR-4469	CLIP-seq
MIRT978297	hsa-miR-4477a	CLIP-seq
MIRT1989979	hsa-miR-4486	CLIP-seq
MIRT1989980	hsa-miR-4500	CLIP-seq
MIRT1989981	hsa-miR-452	CLIP-seq
MIRT1989982	hsa-miR-4533	CLIP-seq
MIRT978299	hsa-miR-4534	CLIP-seq
MIRT978301	hsa-miR-4646-5p	CLIP-seq
MIRT978302	hsa-miR-4647	CLIP-seq
MIRT1989983	hsa-miR-4650-5p	CLIP-seq
MIRT1989984	hsa-miR-4653-3p	CLIP-seq
MIRT978303	hsa-miR-4662b	CLIP-seq
MIRT1989985	hsa-miR-4667-3p	CLIP-seq
MIRT1989986	hsa-miR-4668-3p	CLIP-seq
MIRT1989987	hsa-miR-4676-3p	CLIP-seq
MIRT1989988	hsa-miR-4685-5p	CLIP-seq
MIRT1989989	hsa-miR-4695-5p	CLIP-seq
MIRT978308	hsa-miR-4729	CLIP-seq
MIRT978310	hsa-miR-4762-3p	CLIP-seq
MIRT978312	hsa-miR-4766-5p	CLIP-seq
MIRT1989990	hsa-miR-4789-5p	CLIP-seq
MIRT978321	hsa-miR-548c-3p	CLIP-seq
MIRT978329	hsa-miR-590-3p	CLIP-seq
MIRT978330	hsa-miR-603	CLIP-seq
MIRT1989991	hsa-miR-612	CLIP-seq
MIRT1989992	hsa-miR-616	CLIP-seq
MIRT1989993	hsa-miR-632	CLIP-seq
MIRT978335	hsa-miR-940	CLIP-seq
MIRT1989994	hsa-miR-98	CLIP-seq
MIRT1989940	hsa-miR-1208	CLIP-seq
MIRT1989943	hsa-miR-1285	CLIP-seq
MIRT1989944	hsa-miR-1305	CLIP-seq
MIRT1989949	hsa-miR-3117-5p	CLIP-seq
MIRT1989952	hsa-miR-3148	CLIP-seq
MIRT2224223	hsa-miR-3173-3p	CLIP-seq
MIRT1989956	hsa-miR-3187-5p	CLIP-seq
MIRT1989960	hsa-miR-337-3p	CLIP-seq
MIRT2224224	hsa-miR-342-3p	CLIP-seq
MIRT2224225	hsa-miR-3620	CLIP-seq
MIRT1989963	hsa-miR-3663-5p	CLIP-seq
MIRT1989964	hsa-miR-3685	CLIP-seq
MIRT1989965	hsa-miR-378g	CLIP-seq
MIRT1989967	hsa-miR-384	CLIP-seq
MIRT2224226	hsa-miR-4276	CLIP-seq
MIRT1989976	hsa-miR-4289	CLIP-seq
MIRT2224227	hsa-miR-4292	CLIP-seq
MIRT978294	hsa-miR-4426	CLIP-seq
MIRT1989981	hsa-miR-452	CLIP-seq
MIRT2224228	hsa-miR-4530	CLIP-seq
MIRT978302	hsa-miR-4647	CLIP-seq
MIRT978303	hsa-miR-4662b	CLIP-seq
MIRT1989987	hsa-miR-4676-3p	CLIP-seq
MIRT978308	hsa-miR-4729	CLIP-seq
MIRT2224229	hsa-miR-5096	CLIP-seq
MIRT978321	hsa-miR-548c-3p	CLIP-seq
MIRT1989991	hsa-miR-612	CLIP-seq
MIRT1989992	hsa-miR-616	CLIP-seq
MIRT2224230	hsa-miR-635	CLIP-seq
MIRT1989940	hsa-miR-1208	CLIP-seq
MIRT1989944	hsa-miR-1305	CLIP-seq
MIRT978263	hsa-miR-181a	CLIP-seq
MIRT978264	hsa-miR-181b	CLIP-seq
MIRT978265	hsa-miR-181c	CLIP-seq
MIRT978266	hsa-miR-181d	CLIP-seq
MIRT1989949	hsa-miR-3117-5p	CLIP-seq
MIRT1989960	hsa-miR-337-3p	CLIP-seq
MIRT1989963	hsa-miR-3663-5p	CLIP-seq
MIRT1989964	hsa-miR-3685	CLIP-seq
MIRT978286	hsa-miR-377	CLIP-seq
MIRT1989967	hsa-miR-384	CLIP-seq
MIRT978290	hsa-miR-4262	CLIP-seq
MIRT1989976	hsa-miR-4289	CLIP-seq
MIRT1989981	hsa-miR-452	CLIP-seq
MIRT1989987	hsa-miR-4676-3p	CLIP-seq
MIRT2387700	hsa-miR-570	CLIP-seq
MIRT1989992	hsa-miR-616	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005634	Component	Nucleus	IBA

Other IDs

• MIM: 300741
• HGNC: 16949
• e!Ensembl: ENSG00000184083

Protein

• UniProt ID: Q9NX05
• Protein name: Constitutive coactivator of PPAR-gamma-like protein 2 (Protein FAM120C) (Tumor antigen BJ-HCC-21)
• Tissue specificity: TISSUE SPECIFICITY: Expressed at low levels in a number of tissues. {ECO:0000269|PubMed:14585507}.
• Sequence:

  MGVQGFQEFLEKRCPGAVVPVDLLKLARTVSRQQQQQHLHRQLPPTAALAPGAPRAARGS
  VPLQPPLPPAALGAYSGGAGPIRHHHPAHHFHHHGQAQPGLHPPLPPPPPPQLPGARVLV
  DAGSALPRLYGGYQTDWVCGGQWNAMLGYLSALCQACAYPGGDGLELVVMFPGGLGKDRL
  AEWGRRCQAERQTAQLIVGHVGNKGTPPPRAWFLPPACLSHCVRLALIRFRVKVFQSLED
  HHLEVVAFFRENGFHGLLAHDSEYALYNIPSYYSSHALKLSWNGKNLTTNQFLMQEVAKQ
  LGLKRMNFPIFAALLGNHILPDEDLAAFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKA
  VSEYVSSIKDPSNLDVVGKDVFKQSQSRTEDKIERFKKAVEYYSVTTKLSSLPVGPSFLG
  FRNNRLGNPPLPRNQVGTISAGKPMFSHQVPQKVKYPPPFPVGPNSSLLFSSHALGESHA
  FSEDPMLQNSPFANWAVSYDSSASQFPNYLPSKASPPLGPDSSHSSSSDGDEPNGASSDH
  ITEAFHHQPEWGNPNRDRGSWAQPVDTGVSEASLGDGEPHIPSLLSMSTRNHMDITIPPL
  PPVAPEVLRVAEHRHRRGLMYPYIYHVLTKGEIKIPVCIEDECNMELPPAALLFRSARQY
  VYGVLFSLAETQRKMERLAMRRRLPVEVPSVILKEWSAYKGKSPQTPELVSALTFREWTC
  PNLKKLWLGKAVEDKNRRMRAFLACMKSDTPSMLNPANVPTHLLLMCCVLRYMVQWPGGR
  ILHRHELDTFLAQAVSTQLYEPDRLQELKIEKLDARGIQLAALFMSGVDTALFANDACGQ
  PVPWEHCCPWIYFDGKLFQSKLIKAGRERVSLVELCDGQADLATKVEKMRQSILEGVNMN
  HPPPSALLPSPTFVPPMVPSLYPVSLYSRAMGSMPLPPQGRSRGFAGLHPIPPQGGKLEI
  AGMVVGQWAGSRSSRGRGSFGMQVVSVGGPGKGHGKEQTGRGSKGHKKGNKQGSSDGVSK
  SLELHQGRSRSQVNGNSGALIKEEKSDHRLPAPSQCALSRDSNECNNGNRYLPMNNREKN
  HLQEQKLETVAQRKED

• Sequence length: 1096

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Hepatocellular carcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (8)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	25258334		★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	BEFREE	18498374, 25258334		★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	LHGDN	18498374		★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	12767996, 23221556	Stimulate	★☆☆☆☆ Found in Text Mining only
Kaposi Sarcoma	Kaposi Sarcoma	BEFREE	28336944, 30305361, 31189709, 31578296, 31694948		★☆☆☆☆ Found in Text Mining only
Pervasive Development Disorder	Autism spectrum disorder	BEFREE	25258334		★☆☆☆☆ Found in Text Mining only
Sarcoma Kaposi	Sarcoma	Pubtator	31189709	Associate	★☆☆☆☆ Found in Text Mining only
Siderius X-linked mental retardation syndrome	Syndromic Mental Retardation, X-Linked	BEFREE	18498374		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for FAM120C.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to FAM120C.