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Gene Gene information from NCBI Gene database.
Entrez ID 2140
Gene name EYA transcriptional coactivator and phosphatase 3
Gene symbol EYA3
Synonyms (NCBI Gene)
-
Chromosome 1
Chromosome location 1p35.3
Summary This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. It can act as a mediator of chemoresistance and cell survival in Ewing sarcoma cells, wh
miRNA miRNA information provided by mirtarbase database.
727 Show/Hide all (727)
miRTarBase ID miRNA Experiments Reference
MIRT051785 hsa-let-7c-5p CLASH 23622248
MIRT046133 hsa-miR-30b-5p CLASH 23622248
MIRT053062 hsa-miR-708-5p ImmunoblotImmunoprecipitaionLuciferase reporter assayqRT-PCRWestern blot 22723308
MIRT499167 hsa-miR-6758-5p PAR-CLIP 24398324
MIRT499166 hsa-miR-6856-5p PAR-CLIP 24398324
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
FLI1 Activation 22723308
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29 Show/Hide all (29)
GO ID Ontology Definition Evidence Reference
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004725 Function Protein tyrosine phosphatase activity IBA
GO:0004725 Function Protein tyrosine phosphatase activity IDA 19234442, 19351884
GO:0004725 Function Protein tyrosine phosphatase activity IEA
GO:0004725 Function Protein tyrosine phosphatase activity TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601655 3521 ENSG00000158161
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q99504
Protein name Protein phosphatase EYA3 (EC 3.1.3.48) (Eyes absent homolog 3)
Protein function Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair respo
Family and domains
Sequence
MEEEQDLPEQPVKKAKMQESGEQTISQVSNPDVSDQKPETSSLASNLPMSEEIMTCTDYI
PRSSNDYTSQMYSAKPYAHILSVPVSETAYPGQTQYQTLQQTQPYAVYPQATQTYGLPPF
GALWPGMKPESGLIQTPSPSQHSVLTCTTGLTTSQPSPAHYSYPIQASSTNASLISTSST
IANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDAESTTLAATTYQSE
KPSVMAPAPAAQRLSSGDPSTSPSLSQTTPSKDTDDQSRKNMTSKNRGKRKADATSSQDS
ELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDL
EECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYR
KVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVL
ITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRD
EEIAAKQHNMPFWRITNHGDLVSLHQALELDFL
Sequence length 573
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks