EXOSC10 (exosome component 10)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 5394
• Gene name: Exosome component 10
• Gene symbol: EXOSC10
• Synonyms (NCBI Gene): PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4
• Chromosome: 1
• Chromosome location: 1p36.22

miRNA Show/Hide all (33)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028551	hsa-miR-30a-5p	Proteomics	18668040
MIRT046671	hsa-miR-222-3p	CLASH	23622248
MIRT041716	hsa-miR-484	CLASH	23622248
MIRT041716	hsa-miR-484	CLASH	23622248
MIRT041296	hsa-miR-193b-3p	CLASH	23622248
MIRT617279	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT617278	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT617277	hsa-miR-5193	HITS-CLIP	23824327
MIRT617276	hsa-miR-1281	HITS-CLIP	23824327
MIRT617275	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT617274	hsa-miR-6070	HITS-CLIP	23824327
MIRT617273	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT617272	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT617271	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT617270	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT617269	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT617268	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT617267	hsa-miR-4284	HITS-CLIP	23824327
MIRT617279	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT617278	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT617277	hsa-miR-5193	HITS-CLIP	23824327
MIRT617276	hsa-miR-1281	HITS-CLIP	23824327
MIRT617275	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT617274	hsa-miR-6070	HITS-CLIP	23824327
MIRT617273	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT617272	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT617271	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT617270	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT617269	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT617268	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT617267	hsa-miR-4284	HITS-CLIP	23824327
MIRT2222763	hsa-miR-338-3p	CLIP-seq
MIRT2222764	hsa-miR-4310	CLIP-seq

Gene ontology (GO) Show/Hide all (71)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000175	Function	3'-5'-RNA exonuclease activity	IBA
GO:0000175	Function	3'-5'-RNA exonuclease activity	IEA
GO:0000175	Function	3'-5'-RNA exonuclease activity	IMP	26950371
GO:0000175	Function	3'-5'-RNA exonuclease activity	TAS
GO:0000176	Component	Nuclear exosome (RNase complex)	IBA
GO:0000176	Component	Nuclear exosome (RNase complex)	IDA	26166824
GO:0000176	Component	Nuclear exosome (RNase complex)	IEA
GO:0000176	Component	Nuclear exosome (RNase complex)	NAS	20531386
GO:0000177	Component	Cytoplasmic exosome (RNase complex)	NAS	20531386
GO:0000178	Component	Exosome (RNase complex)	IDA	20531389
GO:0000178	Component	Exosome (RNase complex)	IEA
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA
GO:0000460	Process	Maturation of 5.8S rRNA	IMP	17412707, 20368444
GO:0000467	Process	Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0000467	Process	Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA
GO:0000791	Component	Euchromatin	IMP	20699273
GO:0000956	Process	Nuclear-transcribed mRNA catabolic process	IMP	17545563
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003727	Function	Single-stranded RNA binding	IBA
GO:0004518	Function	Nuclease activity	IEA
GO:0004527	Function	Exonuclease activity	IEA
GO:0004532	Function	RNA exonuclease activity	IDA	17174896
GO:0005515	Function	Protein binding	IPI	14731398, 15231747, 16396833, 17234882, 17412707, 20531386, 21255825, 23143267, 23756462, 24981860, 26496610, 30538148, 33961781, 39251607
GO:0005634	Component	Nucleus	IDA	17545563, 20531386
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	20531386
GO:0005730	Component	Nucleolus	IEA
GO:0005730	Component	Nucleolus	TAS	1383382
GO:0005737	Component	Cytoplasm	IDA	17545563, 20531386
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	20531386
GO:0006139	Process	Nucleobase-containing compound metabolic process	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0006364	Process	RRNA processing	TAS
GO:0006396	Process	RNA processing	IDA	17174896, 20531386
GO:0006396	Process	RNA processing	IEA
GO:0006401	Process	RNA catabolic process	IDA	17174896, 20531386
GO:0006974	Process	DNA damage response	IEA
GO:0008408	Function	3'-5' exonuclease activity	IEA
GO:0010468	Process	Regulation of gene expression	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016787	Function	Hydrolase activity	IEA
GO:0019219	Process	Regulation of nucleobase-containing compound metabolic process	IEA
GO:0032040	Component	Small-subunit processome	IDA	34516797
GO:0032211	Process	Negative regulation of telomere maintenance via telomerase	IMP	26950371
GO:0042274	Process	Ribosomal small subunit biogenesis	IDA	34516797
GO:0046872	Function	Metal ion binding	IEA
GO:0070034	Function	Telomerase RNA binding	IPI	26950371
GO:0071028	Process	Nuclear mRNA surveillance	IMP	17545563, 20699273
GO:0071034	Process	CUT catabolic process	IMP	19056938
GO:0071035	Process	Nuclear polyadenylation-dependent rRNA catabolic process	IBA
GO:0071035	Process	Nuclear polyadenylation-dependent rRNA catabolic process	IMP	16455498
GO:0071036	Process	Nuclear polyadenylation-dependent snoRNA catabolic process	IBA
GO:0071037	Process	Nuclear polyadenylation-dependent snRNA catabolic process	IBA
GO:0071038	Process	TRAMP-dependent tRNA surveillance pathway	IBA
GO:0071039	Process	Nuclear polyadenylation-dependent CUT catabolic process	IBA
GO:0071040	Process	Nuclear polyadenylation-dependent antisense transcript catabolic process	IBA
GO:0071044	Process	Histone mRNA catabolic process	IBA
GO:0071044	Process	Histone mRNA catabolic process	IMP	18172165
GO:0071051	Process	Poly(A)-dependent snoRNA 3'-end processing	IBA
GO:0101019	Component	Nucleolar exosome (RNase complex)	NAS	20531386
GO:1904872	Process	Regulation of telomerase RNA localization to Cajal body	IMP	26950371
GO:1905746	Process	Positive regulation of mRNA cis splicing, via spliceosome	IEA

Other IDs

• MIM: 605960
• HGNC: 9138
• e!Ensembl: ENSG00000171824

Protein

• UniProt ID: Q01780
• Protein name: Exosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2)
• Protein function: Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation
• PDB: 2CPR , 3SAF , 3SAG , 3SAH , 6D6Q , 6D6R , 7MQA
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00570	HRDC	506 → 573	HRDC domain	Domain
  PF01612	DNA_pol_A_exo1	288 → 456		Domain
  PF08066	PMC2NT	44 → 133	PMC2NT (NUC016) domain	Domain

• Sequence:

  MAPPSTREPRVLSATSATKSDGEMVLPGFPDADSFVKFALGSVVAVTKASGGLPQFGDEY
  DFYRSFPGFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSKVTELEDKFDLLVDANDVI
  LERVGILLDEASGVNKNQQPVLPAGLQVPKTVVSSWNRKAAEYGKKAKSETFRLLHAKNI
  IRPQLKFREKIDNSNTPFLPKIFIKPNAQKPLPQALSKERRERPQDRPEDLDVPPALADF
  IHQQRTQQVEQDMFAHPYQYELNHFTPADAVLQKPQPQLYRPIEETPCHFISSLDELVEL
  NEKLLNCQEFAVDLEHHSYRSFLGLTCLMQISTRTEDFIIDTLELRSDMYILNESLTDPA
  IVKVFHGADSDIEWLQKDFGLYVVNMFDTHQAARLLNLGRHSLDHLLKLYCNVDSNKQYQ
  LADWRIRPLPEEMLSYARDDTHYLLYIYDKMRLEMWERGNGQPVQLQVVWQRSRDICLKK
  FIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFAWRDKTARREDESYGYVLPNHMMLKI
  AEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLLKSEVAAGVKKSGPLPSAE
  RLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITL
  FNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEI
  SNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKR
  ERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQF
  DPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGFRYNWPQR

• Sequence length: 885

Pathways

KEGG Pathway:

RNA degradation

Reactome Pathway:

Major pathway of rRNA processing in the nucleolus and cytosol

Related Genes

Sort by: Blended Diseases Pathways Evidence source

MPHOSPH6 2 shared pathwaysRNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol Related via 2 shared pathways including RNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol. C1D 2 shared pathwaysRNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol Related via 2 shared pathways including RNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol. XRN2 2 shared pathwaysRNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol Related via 2 shared pathways including RNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol. MTREX 2 shared pathwaysRNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol Related via 2 shared pathways including RNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol. EXOSC8 2 shared pathwaysRNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol Related via 2 shared pathways including RNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
MPHOSPH6	0	[]	2	["RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol"]	0	[]
C1D	0	[]	2	["RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol"]	0	[]
XRN2	0	[]	2	["RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol"]	0	[]
MTREX	0	[]	2	["RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol"]	0	[]
EXOSC8	0	[]	2	["RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol"]	0	[]

Diseases Linked via Similar Genes

Breast cancer Linked via 1 of 5 related genesMPHOSPH6 Melanoma Linked via 1 of 5 related genesMPHOSPH6 Prostate cancer Linked via 1 of 5 related genesMPHOSPH6 Esophageal squamous cell carcinoma Linked via 1 of 5 related genesC1D Lung cancer Linked via 1 of 5 related genesC1D

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Breast cancer	1	["MPHOSPH6"]
Melanoma	1	["MPHOSPH6"]
Prostate cancer	1	["MPHOSPH6"]
Esophageal squamous cell carcinoma	1	["C1D"]
Lung cancer	1	["C1D"]