EXO5 (exonuclease 5)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 64789
• Gene name: Exonuclease 5
• Gene symbol: EXO5
• Synonyms (NCBI Gene): C1orf176, DEM1, Exo V, hExo5
• Chromosome: 1
• Chromosome location: 1p34.2
• Summary: The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease that can slide along the DNA before cutting it. However, human replication protein A binds ssDNA and restricts sliding of the encoded protein, providing a 5`-directiona

miRNA Show/Hide all (184)

miRTarBase ID	miRNA	Experiments	Reference
MIRT714615	hsa-miR-562	HITS-CLIP	19536157
MIRT714614	hsa-miR-5697	HITS-CLIP	19536157
MIRT714613	hsa-miR-6814-5p	HITS-CLIP	19536157
MIRT714612	hsa-miR-3183	HITS-CLIP	19536157
MIRT714611	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT714610	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT637728	hsa-miR-6787-3p	HITS-CLIP	19536157
MIRT714609	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT714608	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT714607	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT714606	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT714605	hsa-miR-4279	HITS-CLIP	19536157
MIRT637734	hsa-miR-3150a-5p	HITS-CLIP	23824327
MIRT637733	hsa-miR-3150b-5p	HITS-CLIP	23824327
MIRT637731	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT637732	hsa-miR-1208	HITS-CLIP	23824327
MIRT637730	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT637729	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT637728	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT637727	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT637726	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT637725	hsa-miR-7641	HITS-CLIP	23824327
MIRT530993	hsa-miR-548l	PAR-CLIP	21572407
MIRT530992	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT530991	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT530990	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT530989	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT530988	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT530987	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT530986	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT530985	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT530984	hsa-miR-302a-3p	PAR-CLIP	21572407
MIRT530983	hsa-miR-302b-3p	PAR-CLIP	21572407
MIRT530982	hsa-miR-302c-3p	PAR-CLIP	21572407
MIRT530981	hsa-miR-302d-3p	PAR-CLIP	21572407
MIRT530980	hsa-miR-302e	PAR-CLIP	21572407
MIRT530979	hsa-miR-372-3p	PAR-CLIP	21572407
MIRT530978	hsa-miR-373-3p	PAR-CLIP	21572407
MIRT530977	hsa-miR-520a-3p	PAR-CLIP	21572407
MIRT530976	hsa-miR-520b	PAR-CLIP	21572407
MIRT530975	hsa-miR-520c-3p	PAR-CLIP	21572407
MIRT530974	hsa-miR-520d-3p	PAR-CLIP	21572407
MIRT530973	hsa-miR-520e	PAR-CLIP	21572407
MIRT530972	hsa-miR-6074	PAR-CLIP	21572407
MIRT530971	hsa-miR-664a-3p	PAR-CLIP	21572407
MIRT530970	hsa-miR-3973	PAR-CLIP	21572407
MIRT530969	hsa-miR-1283	PAR-CLIP	21572407
MIRT530968	hsa-miR-187-5p	PAR-CLIP	21572407
MIRT530967	hsa-miR-548v	PAR-CLIP	21572407
MIRT530966	hsa-miR-221-3p	PAR-CLIP	21572407
MIRT530965	hsa-miR-222-3p	PAR-CLIP	21572407
MIRT530964	hsa-miR-520d-5p	PAR-CLIP	21572407
MIRT530963	hsa-miR-524-5p	PAR-CLIP	21572407
MIRT530962	hsa-miR-6516-3p	PAR-CLIP	21572407
MIRT530961	hsa-miR-6828-3p	PAR-CLIP	21572407
MIRT530960	hsa-miR-6071	PAR-CLIP	21572407
MIRT530959	hsa-miR-3611	PAR-CLIP	21572407
MIRT530993	hsa-miR-548l	PAR-CLIP	22012620
MIRT530992	hsa-miR-106a-5p	PAR-CLIP	22012620
MIRT530991	hsa-miR-106b-5p	PAR-CLIP	22012620
MIRT530990	hsa-miR-17-5p	PAR-CLIP	22012620
MIRT530989	hsa-miR-20a-5p	PAR-CLIP	22012620
MIRT530988	hsa-miR-20b-5p	PAR-CLIP	22012620
MIRT530987	hsa-miR-519d-3p	PAR-CLIP	22012620
MIRT530986	hsa-miR-526b-3p	PAR-CLIP	22012620
MIRT530985	hsa-miR-93-5p	PAR-CLIP	22012620
MIRT530984	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT530983	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT530982	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT530981	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT530980	hsa-miR-302e	PAR-CLIP	22012620
MIRT530979	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT530978	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT530977	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT530976	hsa-miR-520b	PAR-CLIP	22012620
MIRT530975	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT530974	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT530973	hsa-miR-520e	PAR-CLIP	22012620
MIRT530972	hsa-miR-6074	PAR-CLIP	22012620
MIRT530971	hsa-miR-664a-3p	PAR-CLIP	22012620
MIRT530970	hsa-miR-3973	PAR-CLIP	22012620
MIRT530969	hsa-miR-1283	PAR-CLIP	22012620
MIRT530968	hsa-miR-187-5p	PAR-CLIP	22012620
MIRT530967	hsa-miR-548v	PAR-CLIP	22012620
MIRT530966	hsa-miR-221-3p	PAR-CLIP	22012620
MIRT530965	hsa-miR-222-3p	PAR-CLIP	22012620
MIRT530964	hsa-miR-520d-5p	PAR-CLIP	22012620
MIRT530963	hsa-miR-524-5p	PAR-CLIP	22012620
MIRT530962	hsa-miR-6516-3p	PAR-CLIP	22012620
MIRT530961	hsa-miR-6828-3p	PAR-CLIP	22012620
MIRT530960	hsa-miR-6071	PAR-CLIP	22012620
MIRT530959	hsa-miR-3611	PAR-CLIP	22012620
MIRT714615	hsa-miR-562	HITS-CLIP	19536157
MIRT714614	hsa-miR-5697	HITS-CLIP	19536157
MIRT714613	hsa-miR-6814-5p	HITS-CLIP	19536157
MIRT714612	hsa-miR-3183	HITS-CLIP	19536157
MIRT714611	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT714610	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT637728	hsa-miR-6787-3p	HITS-CLIP	19536157
MIRT714609	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT714608	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT714607	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT714606	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT714605	hsa-miR-4279	HITS-CLIP	19536157
MIRT637734	hsa-miR-3150a-5p	HITS-CLIP	23824327
MIRT637733	hsa-miR-3150b-5p	HITS-CLIP	23824327
MIRT637731	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT637732	hsa-miR-1208	HITS-CLIP	23824327
MIRT637730	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT637729	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT637728	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT637727	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT637726	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT637725	hsa-miR-7641	HITS-CLIP	23824327
MIRT530993	hsa-miR-548l	PAR-CLIP	21572407
MIRT530992	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT530991	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT530990	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT530989	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT530988	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT530987	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT530986	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT530985	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT530984	hsa-miR-302a-3p	PAR-CLIP	21572407
MIRT530983	hsa-miR-302b-3p	PAR-CLIP	21572407
MIRT530982	hsa-miR-302c-3p	PAR-CLIP	21572407
MIRT530981	hsa-miR-302d-3p	PAR-CLIP	21572407
MIRT530980	hsa-miR-302e	PAR-CLIP	21572407
MIRT530979	hsa-miR-372-3p	PAR-CLIP	21572407
MIRT530978	hsa-miR-373-3p	PAR-CLIP	21572407
MIRT530977	hsa-miR-520a-3p	PAR-CLIP	21572407
MIRT530976	hsa-miR-520b	PAR-CLIP	21572407
MIRT530975	hsa-miR-520c-3p	PAR-CLIP	21572407
MIRT530974	hsa-miR-520d-3p	PAR-CLIP	21572407
MIRT530973	hsa-miR-520e	PAR-CLIP	21572407
MIRT530972	hsa-miR-6074	PAR-CLIP	21572407
MIRT530971	hsa-miR-664a-3p	PAR-CLIP	21572407
MIRT530970	hsa-miR-3973	PAR-CLIP	21572407
MIRT530969	hsa-miR-1283	PAR-CLIP	21572407
MIRT530968	hsa-miR-187-5p	PAR-CLIP	21572407
MIRT530967	hsa-miR-548v	PAR-CLIP	21572407
MIRT530966	hsa-miR-221-3p	PAR-CLIP	21572407
MIRT530965	hsa-miR-222-3p	PAR-CLIP	21572407
MIRT530964	hsa-miR-520d-5p	PAR-CLIP	21572407
MIRT530963	hsa-miR-524-5p	PAR-CLIP	21572407
MIRT530962	hsa-miR-6516-3p	PAR-CLIP	21572407
MIRT530961	hsa-miR-6828-3p	PAR-CLIP	21572407
MIRT530960	hsa-miR-6071	PAR-CLIP	21572407
MIRT530959	hsa-miR-3611	PAR-CLIP	21572407
MIRT530993	hsa-miR-548l	PAR-CLIP	22012620
MIRT530992	hsa-miR-106a-5p	PAR-CLIP	22012620
MIRT530991	hsa-miR-106b-5p	PAR-CLIP	22012620
MIRT530990	hsa-miR-17-5p	PAR-CLIP	22012620
MIRT530989	hsa-miR-20a-5p	PAR-CLIP	22012620
MIRT530988	hsa-miR-20b-5p	PAR-CLIP	22012620
MIRT530987	hsa-miR-519d-3p	PAR-CLIP	22012620
MIRT530986	hsa-miR-526b-3p	PAR-CLIP	22012620
MIRT530985	hsa-miR-93-5p	PAR-CLIP	22012620
MIRT530984	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT530983	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT530982	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT530981	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT530980	hsa-miR-302e	PAR-CLIP	22012620
MIRT530979	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT530978	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT530977	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT530976	hsa-miR-520b	PAR-CLIP	22012620
MIRT530975	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT530974	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT530973	hsa-miR-520e	PAR-CLIP	22012620
MIRT530972	hsa-miR-6074	PAR-CLIP	22012620
MIRT530971	hsa-miR-664a-3p	PAR-CLIP	22012620
MIRT530970	hsa-miR-3973	PAR-CLIP	22012620
MIRT530969	hsa-miR-1283	PAR-CLIP	22012620
MIRT530968	hsa-miR-187-5p	PAR-CLIP	22012620
MIRT530967	hsa-miR-548v	PAR-CLIP	22012620
MIRT530966	hsa-miR-221-3p	PAR-CLIP	22012620
MIRT530965	hsa-miR-222-3p	PAR-CLIP	22012620
MIRT530964	hsa-miR-520d-5p	PAR-CLIP	22012620
MIRT530963	hsa-miR-524-5p	PAR-CLIP	22012620
MIRT530962	hsa-miR-6516-3p	PAR-CLIP	22012620
MIRT530961	hsa-miR-6828-3p	PAR-CLIP	22012620
MIRT530960	hsa-miR-6071	PAR-CLIP	22012620
MIRT530959	hsa-miR-3611	PAR-CLIP	22012620

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004527	Function	Exonuclease activity	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	23095756
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	23095756
GO:0005829	Component	Cytosol	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0008310	Function	Single-stranded DNA 3'-5' DNA exonuclease activity	TAS	23095756
GO:0016787	Function	Hydrolase activity	IEA
GO:0036297	Process	Interstrand cross-link repair	IBA
GO:0036297	Process	Interstrand cross-link repair	IMP	23095756
GO:0045145	Function	Single-stranded DNA 5'-3' DNA exonuclease activity	IBA
GO:0045145	Function	Single-stranded DNA 5'-3' DNA exonuclease activity	IDA	23095756
GO:0045145	Function	Single-stranded DNA 5'-3' DNA exonuclease activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051536	Function	Iron-sulfur cluster binding	IEA
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IDA	23095756
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IEA

Other IDs

• MIM: 618601
• HGNC: 26115
• e!Ensembl: ENSG00000164002

Protein

• UniProt ID: Q9H790
• Protein name: Exonuclease V (Exo V) (hExo5) (EC 3.1.-.-) (Defects in morphology protein 1 homolog)
• Protein function: Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with
• PDB: 7LW7 , 7LW8 , 7LW9 , 7LWA
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09810	Exo5	71 → 194		Family
  PF09810	Exo5	263 → 355		Family

• Sequence:

  MAETREEETVSAEASGFSDLSDSEFLEFLDLEDAQESKALVNMPGPSSESLGKDDKPISL
  QNWKRGLDILSPMERFHLKYLYVTDLATQNWCELQTAYGKELPGFLAPEKAAVLDTGASI
  HLARELELHDLVTVPVTTKEDAWAIKFLNILLLIPTLQSEGHIREFPVFGEGEGVLLVGV
  IDELHYTAKGELELAELKTRRRPMLPLEAQKKKDCFQVSLYKYIFDAMVQGKVTPASLIH
  HTKLCLEKPLGPSVLRHAQQGGFSVKSLGDLMELVFLSLTLSDLPVIDILKIEYIHQETA
  TVLGTEIVAFKEKEVRAKVQHYMAYWMGHREPQGVDVEEAWKCRTCTYADICEWRKGSGV
  LSSTLAPQVKKAK

• Sequence length: 373

Related Genes

No strongly related genes found yet for EXO5.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to EXO5.