ERVK-7 (endogenous retrovirus group K member 7)

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Gene Gene information from NCBI Gene database.
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Entrez ID 449619
Gene name Endogenous retrovirus group K member 7
Gene symbol ERVK-7
Synonyms (NCBI Gene)
ERVK7HERV-K(III)HERV-K102HERV-KIII
Chromosome 1
Chromosome location 1q22
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0000731 Process DNA synthesis involved in DNA repair IEA
GO:0003676 Function Nucleic acid binding IEA
GO:0003677 Function DNA binding IEA
GO:0003824 Function Catalytic activity IEA
GO:0003964 Function RNA-directed DNA polymerase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
614013 31828 HGNC
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61567
Protein name Endogenous retrovirus group K member 7 Env polyprotein (Envelope polyprotein) (HERV-K(III) envelope protein) (HERV-K102 envelope protein) (HERV-K_1q22 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]
Protein function Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.; SU mediates receptor recognit
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00517 GP41 375 → 571 Family
PF13804 HERV-K_env_2 4 → 172 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in lung, placenta, testis and peripheral blood lymphocytes. {ECO:0000269|PubMed:11401426}.
Sequence
Sequence length 588
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P63130
Protein name Endogenous retrovirus group K member 7 Gag polyprotein (HERV-K(III) Gag protein) (HERV-K102 Gag protein) (HERV-K_1q22 provirus ancestral Gag polyprotein) (Gag polyprotein)
Protein function The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form mem
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00098 zf-CCHC 544 → 561 Zinc knuckle Domain
PF00607 Gag_p24 312 → 512 Family
PF02337 Gag_p10 11 → 93 Family
PF14787 zf-CCHC_5 578 → 613 Domain
Sequence 
MGQTKSKIKSKYASYLSFIKILLKRGGVKVSTKNLIKLFQIIEQFCPWFPEQGTLDLKDW
KRIGKELKQAGRKGNIIPLTVWNDWAIIKAALEPFQTEKDSVSVSDALGSCIIDCNENTR
KKSQKETEGLHCEYVAEPVMAQSTQNVDYNQLQEVIYPETLKLEGKGPELVGPSESKPRG
TSHLPAGQVPVTLQPQKQVKENKTQPPVAYQYWPPAELQYRPPPESQYGYPGMPPAPQGR
APYPQPPTRRLNPTAPPSRQGSELHEIIDKSRKEGDTEAWQFPVTLEPMPPGEGAQEGEP
PTVEARYKSFSIKMLKDMKEGVKQYGPNSPYMRTLLDSIAHGHRLIPYDWEILAKSSLSP
SQFLQFKTWWIDGVQEQVRRNRAANPPVNIDADQLLGIGQNWSTISQQALMQNEAIEQVR
AICLRAWEKIQDPGSTCPSFNTVRQGSKEPYPDFVARLQDVAQKSIADEKARKVIVELMA
YENANPECQSAIKPLKGKVPAGSDVISEYVKACDGIGGAMHKAMLMAQAITGVVLGGQVR
TFGGKCYNCGQIGHLKKNCPVLNKQNITIQATTTGREPPDLCPRCKKGKHWASQCRSKFD
KNGQPLSGNEQRGQPQAPQQTGAFPIQPFVPQGFQEQQPPLSQVFQGISQLPQYNNCPPP
QAAVQQ
Sequence length 666
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P63131
Protein name Endogenous retrovirus group K member 7 Pro protein (HERV-K(III) Pro protein) (HERV-K102 Pro protein) (HERV-K_1q22 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)
Protein function Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution. This endogenous protein
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00077 RVP 6 → 105 Domain
PF01585 G-patch 111 → 155 G-patch domain Family
Sequence
Sequence length 156
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P63135
Protein name Endogenous retrovirus group K member 7 Pol protein (HERV-K(III) Pol protein) (HERV-K102 Pol protein) (HERV-K_1q22 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]
Protein function Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA p
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00075 RNase_H 461 → 590 RNase H Domain
PF00078 RVT_1 76 → 245 Reverse transcriptase (RNA-dependent DNA polymerase) Family
PF00517 GP41 1246 → 1442 Family
PF00665 rve 644 → 739 Domain
PF02022 Integrase_Zn 592 → 629 Domain
PF06817 RVT_thumb 252 → 317 Domain
PF13804 HERV-K_env_2 875 → 1043 Domain
PF00552 IN_DBD_C 813 → 857 Domain
Sequence 
NKSRKRRNRLSFLGAATVEPPKPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKG
HIEPSFSPWNSPVFVIQKKSGKWRMLTDLRAVNAVIQPMGPLQPGLPSPAMIPKDWPLII
IDLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTICQTFVGRAL
QPVREKFSDCYIIHYIDDILCAAETRDKLIDCYTFLQAEVANAGLAIASDKIQTSTPFHY
LGMQIENRKIKQQKIEIRKDTLKTLNDFQKLLGDINWIRPTLGIPTYAMSNLFSILRGDS
DLNSKRILTPEATKEIKLVEEKIQSAQINRIDPLAPLQLLIFATAHSPTGIIIQNTDLVE
WSFLPHSTVKTFTLYLDQIATLIGQTRLRIIKLCGNDPDKIVVPLTKEQVRQAFINSGAW
QIGLANFVGIIDNHYPKTKIFQFLKLTTWILPKITRREPLENALTVFTDGSSNGKAAYTG
PKERVIKTPYQSAQRAELVAVITVLQDFDQPINIISDSAYVVQATRDVETALIKYSMDDQ
LNQLFNLLQQTVRKRNFPFYITHIRAHTNLPGPLTKANEQADLLVSSALIKAQELHALTH
VNAAGLKNKFDVTWKQAKDIVQHCTQCQILHLPTQEAGVNPRGLCPNALWQMDVTHVPSF
GRLSYVHVTVDTYSHFIWATCQTGESTSHVKKHLLSCFAVMGVPEKIKTDNGPGYCSKAF
QKFLSQWKISHTTGIPYNSQGQAIVERTNRTLKTQLVKQKEGGDSKECTTPQMQLNLALY
TLNFLNIYRNQTTTSAEQHLTGKKNSPHEGKLIWWKDNKNKTWEIGKVITWGRGFACVSP
GENQLPVWIPTRHLKFYNEPIGDAKKRASTEMVTPVTWMDNPIEIYVNDSVWVPGPIDDR
CPAKPEEEGMMINISIGYRYPPICLGRAPGCLMPAVQNWLVEVPTVSPISRFTYHMVSGM
SLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVILQNNEFG
TIIDWAPRGQFYHNCSGQTQSCPSAQVSPAVDSDLTESLDKHKHKKLQSFYPWEWGEKGI
STPRPKIVSPVSGPEHPELWRLTVASHHIRIWSGNQTLETRDCKPFYTIDLNSSLTVPLQ
SCVKPPYMLVVGNIVIKPDSQTITCENCRLLTCIDSTFNWQHRILLVRAREGVWIPVSMD
RPWEASPSVHILTEVLKGVLNRSKRFIFTLIAVIMGLIAVTATAAVAGVALHSSVQSVNF
VNDWQKNSTRLWNSQSSIDQKLANQINDLRQTVIWMGDRLMSLEHRFQLQCDWNTSDFCI
TPQIYNESEHHWDMVRRHLQGREDNLTLDISKLKEQIFEASKAHLNLVPGTEAIAGVADG
LANLNPVTWVKTIGSTTIINLILILVCLFCLLLVCRCTQQLRRDSDHRERAMMTMAVLSK
RKGGNVGKSKRDQIVTVSV
Sequence length 1459
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61582
Protein name Endogenous retrovirus group K member 7 Np9 protein (HERV-K(III) Np9 protein) (HERV-K102 Np9 protein) (HERV-K_1q22 provirus Np9 protein)
Protein function May possess a function in tumorigenesis.
Family and domains
Sequence 
MNPLEMQRKGPPRRWCLQVYPTAPKRQRPSRTGHDDDGGFVEKKRGKCGEKQERSDCYCV
CVERSRHGRLHFVMC
Sequence length 75
Interactions View interactions

No strongly related genes found yet for ERVK-7.

No additional diseases found yet through genes similar to ERVK-7.