ERVK-6 (endogenous retrovirus group K member 6, envelope)

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Gene Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 64006
• Gene name: Endogenous retrovirus group K member 6, envelope
• Gene symbol: ERVK-6
• Synonyms (NCBI Gene): ERVK6, HERV-K(C7), HERV-K108, K-Rev, c-orf, cORF, envK2
• Chromosome: 7
• Chromosome location: 7p22.1

Gene ontology (GO) Show/Hide all (49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000731	Process	DNA synthesis involved in DNA repair	IEA
GO:0000768	Process	Syncytium formation by plasma membrane fusion	IDA	14557543
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003723	Function	RNA binding	IDA	10557333
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	IMP	11000203
GO:0003824	Function	Catalytic activity	IEA
GO:0003964	Function	RNA-directed DNA polymerase activity	IEA
GO:0004190	Function	Aspartic-type endopeptidase activity	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0004523	Function	RNA-DNA hybrid ribonuclease activity	IEA
GO:0005198	Function	Structural molecule activity	IEA
GO:0005515	Function	Protein binding	IPI	10557333, 10980608, 11000203
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IDA	10557333
GO:0005730	Component	Nucleolus	IEA
GO:0005730	Component	Nucleolus	IMP	10516058
GO:0005737	Component	Cytoplasm	IDA	10557333
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	IMP	10516058, 11000203
GO:0005886	Component	Plasma membrane	IEA
GO:0006261	Process	DNA-templated DNA replication	IEA
GO:0006278	Process	RNA-templated DNA biosynthetic process	IEA
GO:0006310	Process	DNA recombination	IEA
GO:0006406	Process	MRNA export from nucleus	IDA	10557333, 11581404
GO:0006406	Process	MRNA export from nucleus	IMP	10516058, 11000203
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010628	Process	Positive regulation of gene expression	IDA	10557333, 10980608, 11105755, 11581404
GO:0010628	Process	Positive regulation of gene expression	IMP	10516058, 11000203
GO:0015074	Process	DNA integration	IEA
GO:0016020	Component	Membrane	IEA
GO:0016032	Process	Viral process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0032991	Component	Protein-containing complex	IDA	10557333
GO:0032991	Component	Protein-containing complex	IMP	10980608
GO:0034061	Function	DNA polymerase activity	IEA
GO:0035613	Function	RNA stem-loop binding	IBA
GO:0035613	Function	RNA stem-loop binding	IDA	11105755, 11581404
GO:0042803	Function	Protein homodimerization activity	IDA	10557333
GO:0046872	Function	Metal ion binding	IEA
GO:0051028	Process	MRNA transport	IEA
GO:0051260	Process	Protein homooligomerization	IMP	11000203
GO:0075523	Process	Viral translational frameshifting	IEA

Other IDs

• MIM: 605626
• HGNC: 13915
• e!Ensembl: HGNC

Protein

• UniProt ID: Q69383
• Protein name: Endogenous retrovirus group K member 6 Rec protein (Central open reading frame) (c-orf) (cORF) (Endogenous retrovirus K protein 6) (HERV-K(C7) Rec protein) (HERV-K(HML-2.HOM) Rec protein) (HERV-K108 Rec protein) (HERV-K_7p22.1 provirus Rec protein) (K-Rev
• Protein function: Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15695	HERV-K_REC	19 → 105		Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed at higher level in placenta, expressed at lower level in several organs and cell lines. {ECO:0000269|PubMed:12083821}.
• Sequence:

  MNPSEMQRKAPPRRRRHRNRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLA
  TKYLENTKVTQTPESMLLAALMIVSMVSAGVPNSSEETATIENGP

• Sequence length: 105
• UniProt ID: Q69384
• Protein name: Endogenous retrovirus group K member 6 Env polyprotein (EnvK2 protein) (Envelope polyprotein) (HERV-K(C7) envelope protein) (HERV-K(HML-2.HOM) envelope protein) (HERV-K108 envelope protein) (HERV-K_7p22.1 provirus ancestral Env polyprotein) [Cleaved into:
• Protein function: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has los
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00517	GP41	486 → 682		Family
  PF13804	HERV-K_env_2	115 → 283		Domain
  PF15695	HERV-K_REC	19 → 105		Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in testis, and peripheral blood lymphocytes. {ECO:0000269|PubMed:11401426}.
• Sequence:

  MNPSEMQRKAPPRRRRHRNRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLA
  TKYLENTKVTQTPESMLLAALMIVSMVVSLPMPAGAAAANYTYWAYVPFPPLIRAVTWMD
  NPTEVYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYHYPPICLGRAPGCLMPAVQNWL
  VEVPTVSPICRFTYHMVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEV
  LVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNCSGQTQSCPSAQVSPAVDSDLTESLD
  KHKHKKLQSFYPWEWGEKGISTPRPKIVSPVSGPEHPELWRLTVASHHIRIWSGNQTLET
  RDRKPFYTIDLNSSLTVPLQSCVKPPYMLVVGNIVIKPDSQTITCENCRLLTCIDSTFNW
  QHRILLVRAREGVWIPVSMDRPWEASPSVHILTEVLKGVLNRSKRFIFTLIAVIMGLIAV
  TATAAVAGVALHSSVQSVNFVNDWQKNSTRLWNSQSSIDQKLANQINDLRQTVIWMGDRL
  MSLEHRFQLQCDWNTSDFCITPQIYNESEHHWDMVRRHLQGREDNLTLDISKLKEQIFEA
  SKAHLNLVPGTEAIAGVADGLANLNPVTWVKTIGSTTIINLILILVCLFCLLLVCRCTQQ
  LRRDSDHRERAMMTMAVLSKRKGGNVGKSKRDQIVTVSV

• Sequence length: 699
• UniProt ID: Q9BXR3
• Protein name: Endogenous retrovirus group K member 6 Pol protein (HERV-K(C7) Pol protein) (HERV-K(HML-2.HOM) Pol protein) (HERV-K108 Pol protein) (HERV-K_7p22.1 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H
• Protein function: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA p
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00075	RNase_H	461 → 590	RNase H	Domain
  PF00078	RVT_1	76 → 245	Reverse transcriptase (RNA-dependent DNA polymerase)	Family
  PF00665	rve	644 → 739		Domain
  PF02022	Integrase_Zn	592 → 629		Domain
  PF06817	RVT_thumb	252 → 317		Domain
  PF00552	IN_DBD_C	813 → 857		Domain

• Sequence:

  NKSRKRRNRESLLGAATVEPPKPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKG
  HIEPSFSPWNSPVFVIQKKSGKWRMLTDLRAVNAVIQPMGPLQPGLPSPAMIPKDWPLII
  IDLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTICQTFVGRAL
  QPVREKFSDCYIIHCIDDILCAAETKDKLIDCYTFLQAEVANAGLAIASDKIQTSTPFHY
  LGMQIENRKIKPQKIEIRKDTLKTLNDFQKLLGDINWIRPTLGIPTYAMSNLFSILRGDS
  DLNSKRMLTPEATKEIKLVEEKIQSAQINRIDPLAPLQLLIFATAHSPTGIIIQNTDLVE
  WSFLPHSTVKTFTLYLDQIATLIGQTRLRIIKLCGNDPDKIVVPLTKEQVRQAFINSGAW
  KIGLANFVGIIDNHYPKTKIFQFLKLTTWILPKITRREPLENALTVFTDGSSNGKAAYTG
  PKERVIKTPYQSAQRAELVAVITVLQDFDQPINIISDSAYVVQATRDVETALIKYSMDDQ
  LNQLFNLLQQTVRKRNFPFYITHIRAHTNLPGPLTKANEQADLLVSSALIKAQELHALTH
  VNAAGLKNKFDVTWKQAKDIVQHCTQCQVLHLPTQEAGVNPRGLCPNALWQMDVTHVPSF
  GRLSYVHVTVDTYSHFIWATCQTGESTSHVKKHLLSCFAVMGVPEKIKTDNGPGYCSKAF
  QKFLSQWKISHTTGIPYNSQGQAIVERTNRTLKTQLVKQKEGGDSKECTTPQMQLNLALY
  TLNFLNIYRNQTTTSAEQHLTGKKNSPHEGKLIWWKDNKNKTWEIGKVITWGRGFACVSP
  GENQLPVWIPTRHLKFYNEPIRDAKKSTSAETETSQSSTVDSQDEQNGDVRRTDEVAIHQ
  EGRAANLGTTKEADAVSYKISREHKGDTNPREYAACSLDDCINGGKSPYACRSSCS

• Sequence length: 956
• UniProt ID: Q7LDI9
• Protein name: Endogenous retrovirus group K member 6 Gag polyprotein (HERV-K(C7) Gag protein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K_7p22.1 provirus ancestral Gag polyprotein) (Gag polyprotein)
• Protein function: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form mem
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00098	zf-CCHC	544 → 561	Zinc knuckle	Domain
  PF00607	Gag_p24	312 → 512		Family
  PF02337	Gag_p10	11 → 93		Family
  PF14787	zf-CCHC_5	578 → 613		Domain

• Sequence:

  MGQTKSKIKSKYASYLSFIKILLKRGGVKVSTKNLIKLFQIIEQFCPWFPEQGTLDLKDW
  KRIGKELKQAGRKGNIIPLTVWNDWAIIKAALEPFQTEEDSVSVSDAPGSCIIDCNENTR
  KKSQKETEGLHCEYVAEPVMAQSTQNVDYNQLQEVIYPETLKLEGKGPELVGPSESKPRG
  TSPLPAGQVPVTLQPQKQVKENKTQPPVAYQYWPPAELQYRPPPESQYGYPGMPPAPQGR
  APYPQPPTRRLNPTAPPSRQGSKLHEIIDKSRKEGDTEAWQFPVTLEPMPPGEGAQEGEP
  PTVEARYKSFSIKKLKDMKEGVKQYGPNSPYMRTLLDSIAHGHRLIPYDWEILAKSSLSP
  SQFLQFKTWWIDGVQEQVRRNRAANPPVNIDADQLLGIGQNWSTISQQALMQNEAIEQVR
  AICLRAWEKIQDPGSTCPSFNTVRQGSKEPYPDFVARLQDVAQKSIADEKARKVIVELMA
  YENANPECQSAIKPLKGKVPAGSDVISEYVKACDGIGGAMHKAMLMAQAITGVVLGGQVR
  TFGRKCYNCGQIGHLKKNCPVLNKQNITIQATTTGREPPDLCPRCKKGKHWASQCRSKFD
  KNGQPLSGNEQRGQPQAPQQTGAFPIQPFVPQGFQGQQPPLSQVFQGISQLPQYNNCPPP
  QAAVQQ

• Sequence length: 666
• UniProt ID: Q9Y6I0
• Protein name: Endogenous retrovirus group K member 6 Pro protein (HERV-K(C7) Pro protein) (HERV-K(HML-2.HOM) Pro protein) (HERV-K108 Pro protein) (HERV-K_7p22.1 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)
• Protein function: Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00077	RVP	6 → 105		Domain
  PF01585	G-patch	111 → 155	G-patch domain	Family

• Sequence:

  WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGIGTASE
  VYQSTEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPAPSYSPTSQKIMT
  KMGYIPGKGLGKNEDGIKIPVEAKINQEREGIGNPC

• Sequence length: 156

Related Genes

No strongly related genes found yet for ERVK-6.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ERVK-6.