ERVK-5 (endogenous retrovirus group K member 5)

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Gene Gene information from NCBI Gene database.
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Entrez ID 60358
Gene name Endogenous retrovirus group K member 5
Gene symbol ERVK-5
Synonyms (NCBI Gene)
ERVK5HERV-K(II)HERV-KII
Chromosome 3
Chromosome location 3q12.3
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9 Show/Hide all (9)
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GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0005198 Function Structural molecule activity IEA
GO:0005634 Component Nucleus IEA
GO:0005886 Component Plasma membrane IEA
GO:0008270 Function Zinc ion binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
614012 13757 HGNC
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9HDB9
Protein name Endogenous retrovirus group K member 5 Gag polyprotein (HERV-K(II) Gag protein) (HERV-K_3q12.3 provirus ancestral Gag polyprotein) (Gag polyprotein)
Protein function The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form mem
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00098 zf-CCHC 543 → 560 Zinc knuckle Domain
PF00607 Gag_p24 312 → 511 Family
PF02337 Gag_p10 11 → 93 Family
PF14787 zf-CCHC_5 578 → 613 Domain
Sequence 
MGQTKSKTKSKYASYLSFIKILLKRGGVRVSTKNLIKLFQIIEQFCPWFPEQGTLDLKDW
KRIGEELKQAGRKGNIIPLTVWNDWAIIKAALEPFQTKEDSVSVSDAPGSCVIDCNEKTG
RKSQKETESLHCEYVTEPVMAQSTQNVDYNQLQGVIYPETLKLEGKGPELVGPSESKPRG
PSPLPAGQVPVTLQPQTQVKENKTQPPVAYQYWPPAELQYLPPPESQYGYPGMPPALQGR
APYPQPPTVRLNPTASRSGQGGTLHAVIDEARKQGDLEAWRFLVILQLVQAGEETQVGAP
ARAETRCEPFTMKMLKDIKEGVKQYGSNSPYIRTLLDSIAHGNRLTPYDWESLAKSSLSS
SQYLQFKTWWIDGVQEQVRKNQATKPTVNIDADQLLGTGPNWSTINQQSVMQNEAIEQVR
AICLRAWGKIQDPGTAFPINSIRQGSKEPYPDFVARLQDAAQKSITDDNARKVIVELMAY
ENANPECQSAIKPLKGKVPAGVDVITEYVKACDGIGGAMHKAMLMAQAMRGLTLGGQVRT
FGKKCYNCGQIGHLKRSCPVLNKQNIINQAITAKNKKPSGLCPKCGKGKHWANQCHSKFD
KDGQPLSGNRKRGQPQAPQQTGAFPVQLFVPQGFQGQQPLQKIPPLQGVSQLQQSNSCPA
PQQAAPQ
Sequence length 667
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9HDB8
Protein name Endogenous retrovirus group K member 5 Env polyprotein (Envelope polyprotein) (HERV-K(II) envelope protein) (HERV-K_3q12.3 provirus ancestral Env polyprotein) [Includes: Truncated surface protein (SU)]
Protein function Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13804 HERV-K_env_2 4 → 172 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in lung, placenta, testis, peripheral blood lymphocytes, and teratocarcinoma cell lines.
Sequence 
MVTPVTWMDNPIEVYVNDSVWVPGPTDDRCPAKPEEEGMMINISIVYRYPPICLGRAPGC
LMPAVQNWLVEVPTVSPNSRFTYHMVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEI
PKESKNTEVLVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNCSGQTQSCPSAQVSPAV
DSDLTESLDKHKHKKLQSFYPWEWGEKGISTPRPEIISPVSGPEHPELWRLWPDTTLEFG
LEIKL
Sequence length 245
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61583
Protein name Endogenous retrovirus group K member 5 Np9 protein (Endogenous retrovirus K protein 5) (HERV-K(II) Np9 protein) (HERV-K_3q12.3 provirus Np9 protein)
Protein function May possess a function in tumorigenesis.
Family and domains
Sequence 
MNPSEMQRKGPPQRWCLQVYPTAPKRQRPSRTGHDDDGGFVEKKRGKCGEKQERSDCYCV
CVERSRHRRLHFVLY
Sequence length 75
Interactions View interactions

No strongly related genes found yet for ERVK-5.

No additional diseases found yet through genes similar to ERVK-5.