ERVK-25 (endogenous retrovirus group K member 25)

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Gene Gene information from NCBI Gene database.
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Entrez ID 100862683
Gene name Endogenous retrovirus group K member 25
Gene symbol ERVK-25
Synonyms (NCBI Gene)
PRProteaseProteinasec11_A
Chromosome 11
Chromosome location 11q22.1
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0004190 Function Aspartic-type endopeptidase activity IEA
GO:0005198 Function Structural molecule activity IEA
GO:0005886 Component Plasma membrane IEA
GO:0006508 Process Proteolysis IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
HGNC N/A N/A
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P63136
Protein name Endogenous retrovirus group K member 25 Pol protein (HERV-K_11q22.1 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]
Protein function Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA p
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00075 RNase_H 461 → 588 RNase H Domain
PF00078 RVT_1 76 → 245 Reverse transcriptase (RNA-dependent DNA polymerase) Family
PF00665 rve 642 → 737 Domain
PF02022 Integrase_Zn 590 → 627 Domain
PF06817 RVT_thumb 252 → 317 Domain
PF00552 IN_DBD_C 811 → 855 Domain
Sequence 
NKSKKRRNRVSFLGAATVEPPKPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKG
HIEPSFSPWNSPVFVIQKKSGKWRMLTDLRAVNAVIQPMGPLQPGLPSPAMIPKDWPLII
IDLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTICQTFVGRAL
QPVREKFSDCYIIHYIDDILCAAETKDKLIDCYTFLQAEVANAGLAIASDKIQTSTPFHY
LGMQIENRKIKPQKIEIRKDTLKALNDFQKLLGDINWIRPTLGIPTYAMSNLFSILRGDS
DLNSKRMLTPEATKEIKLVEEKIQSAQINRIDPLAPLQLLIFATAHSPTGIIIQNTDLVE
WSFLPHSTVKTFTLYLDQIATLIGQTRLRIIKLCGNDPDKIVVPLTKEQVRQAFINSGAW
QIGLANFVGIIDNHYPKTKIFQFLKLTTWILPKITRREPLENALTVFTDGSSNGKAAYTG
PKERVIKTPYQSAQRAELVAVITVLQDFDINIISDSAYVVQATRDVETALIKYSMDDQLN
QLFNLLQQTVRKRNFPFYITHIRAHTNLPGPLTKANKQADLLVSSALIKAQELHALTHVN
AAGLKNKFDVTWKLAKDIVQHCTQCQVLHLPTQEAGVNPRGLCPNALWQMDVTHVPSFGR
LSYVHVTVDTYSHFIWATCHTGESTSHVKKHLLSCFAVMGVPEKIKTDNGPGYCSKAFQK
FLSQWKISHTTGIPYNSQGQAIVERTNRTLKTQLVKQKEGGDSKECTTPQMQLNLALYTL
NFLNIYRNQTTTSAEQHLTGKKNSPHEGKLIWWKDNKNKTWEIGKVITWGRGFACVSPGE
NQLPVWIPTRHLKFYNEPIRDAKKSTSAETETPQSSTVDSQDEQNGDVRRTDEVAIHQEG
RAANLGTTKEADAVSYKISREHKGDTNPREYAACSLDDCINGGKSPYACRSSCS
Sequence length 954
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61570
Protein name Endogenous retrovirus group K member 25 Env polyprotein (Envelope polyprotein) (HERV-K_11q22.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]
Protein function Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity). ; FUNCTION
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00517 GP41 486 → 661 Family
PF13804 HERV-K_env_2 115 → 283 Domain
PF15695 HERV-K_REC 19 → 105 Family
Sequence 
MNPSEMQRKAPPRRRRHRNRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLA
TKYLENTKVTQTPESMLLAALMIVSMVVSLPMPAGAAAANYTYWAYVPFPPLIRAVTWMD
NPIEVYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYRYPPICLGTAPGCLMPAVQNWL
VEVPIVSPISRFTYHMVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEV
LVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNCSGQTQSCPSAQVSPAVDSDLTESLD
KHKHKKLQSFYPWEWGEKGISTPRPKIVSPVSGPEHPELWRLTVASHHIRIWSGNQTLET
RDRKPFYTVDLNSSLTVPLQSCVKPPYMLVVGNIVIKPDSQTITCENCRLLTCIDSTFNW
QHRILLVRAREGVWIPVSMDRPWEASPSIHILTEVLKGVLNRSKRFIFTLIAVIMGLIAV
TATGAVAGVALHSSVQSVNFVNDWQKNSTRLWNSQSSIDQKLANQINDLRQTVIWMGDRL
MSLEHRFQLQCDWNTSDFCITPQIYNESEHHWDMVRRHLQGREDNLTLDISKLKEQIFKA
SKAHLNLVPGTEAIAGVADGLANLNPVTWVKTIGSTTIINLILILVCLFCLLLVCRCTQQ
L
Sequence length 661
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P63125
Protein name Endogenous retrovirus group K member 25 Pro protein (HERV-K_11q22.1 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)
Protein function Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution. This endogenous protein
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00077 RVP 6 → 105 Domain
PF01585 G-patch 111 → 155 G-patch domain Family
Sequence 
WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGVGTASE
VYQSTEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPAPLYSPTSQKIMT
KMGYIPGKGLGKNEDGIKIPVEAKINQKREGIGYPF
Sequence length 156
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61579
Protein name Endogenous retrovirus group K member 25 Rec protein (Endogenous retrovirus group K member 25) (HERV-K_11q22.1 provirus Rec protein)
Protein function Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15695 HERV-K_REC 19 → 105 Family
Sequence 
MNPSEMQRKAPPRRRRHRNRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLA
TKYLENTKVTQTPESMLLAALMIVSMVSAGVPNSSEETATIENGP
Sequence length 105
Interactions View interactions

No strongly related genes found yet for ERVK-25.

No additional diseases found yet through genes similar to ERVK-25.