ERVK-24 (endogenous retrovirus group K member 24)

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Gene Gene information from NCBI Gene database.
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Entrez ID 100862684
Gene name Endogenous retrovirus group K member 24
Gene symbol ERVK-24
Synonyms (NCBI Gene)
HERV-K101PRProteaseProteinasec22_A
Chromosome 22
Chromosome location 22q11.21
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13 Show/Hide all (13)
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GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0004190 Function Aspartic-type endopeptidase activity IEA
GO:0005198 Function Structural molecule activity IEA
GO:0005634 Component Nucleus IEA
GO:0005886 Component Plasma membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
HGNC N/A N/A
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61566
Protein name Endogenous retrovirus group K member 24 Env polyprotein (Envelope polyprotein) (HERV-K101 envelope protein) (HERV-K_22q11.21 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]
Protein function Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.; SU mediates receptor recognit
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00517 GP41 375 → 571 Family
PF13804 HERV-K_env_2 4 → 172 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in teratocarcinoma cell line. {ECO:0000269|PubMed:11401426}.
Sequence 
MVTPVTWMDNPIEVYVNDSEWVPGPTDDRCPAKPEEEGMMINISIGYRYPPICLGTAPGC
LMPAVQNWLVEVPIVSPISRFTYHMVSGMSLRPRVNYLQDFPYQRSLKFRPKGKPCPKEI
PKESKNTEVLVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNCSGQTQSCPSAQVSPAV
DSDLTESLDKHKHKKLQSFYPWEWGEKGISTPRPKIISPVSGPEHPELWRLTVASHHIRI
WSGNQTLETRDRKPFYTVDLNSSLTLPLQSCVKPPYMLVVGNIVIKPDSQTITCENCRLL
TCIDSTFNWQHRILLVRAREGVWILVSMDRPWEASPSVHILTEVLKGVLNRSKRFIFTLI
AVIMGLIAVTATGAVAGVALHSSVQSVNFVNDWQKNSTRLWNSQSSIDQKLANQINDLRQ
TVIWMGDRLMSLEHRFQLQCDWNTSDFCITPQIYNESEHHWDMVRHHLQGREDNLTLDIS
KLKEQIFEASKAHLNLVPGTEAIAGVADGLANLNPVTWVKTIGSTTIINLILILVCLFCL
LLVCRCTQQLRRDSDHRERAMMTMAVLSKRKGGNVGKSKRDQIVTVSV
Sequence length 588
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P63129
Protein name Endogenous retrovirus group K member 24 Pro protein (HERV-K101 envelope protein) (HERV-K_22q11.21 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)
Protein function Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution. This endogenous protein
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00077 RVP 6 → 105 Domain
PF01585 G-patch 111 → 155 G-patch domain Family
Sequence 
WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGIGTASE
VYQSTEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPAPLYSPTSQKIMT
KMGYIPGKGLGKNEDGIKIPFEAKINQKREGIGYPF
Sequence length 156
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P63145
Protein name Endogenous retrovirus group K member 24 Gag polyprotein (HERV-K101 Gag protein) (HERV-K_22q11.21 provirus ancestral Gag polyprotein) (Gag polyprotein)
Protein function The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form mem
PDB 6SSJ , 6SSK , 6SSL , 6SSM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00098 zf-CCHC 544 → 561 Zinc knuckle Domain
PF00607 Gag_p24 312 → 512 Family
PF02337 Gag_p10 11 → 93 Family
PF14787 zf-CCHC_5 578 → 613 Domain
Sequence 
MGQTKSKIKSKYASYLSFIKILLKRGGVKVSTKNLIKLFQIIEQFCPWFPEQGTLDLKDW
KRIGKELKQAGRKGNIIPLTVWNDWAIIKAALEPFQTEEDSVSVSDAPGSCLIDCNEKTR
KKSQKETESLHCEYVAEPVMAQSTQNVDYNQLQEVIYPETLKLEGKGPELVGPSESKPRG
TSPLPAGQVPVTLQPQKQVKENKTQPPVAYQYWPPAELQYRPPPESQYGYPGMPPAPQGR
APYPQPPTRRLNPTAPPSRQGSELHEIIDKSRKEGDTEAWQFPVTLEPMPPGEGAQEGEP
PTVEARYKSFSIKMLKDMKEGVKQYGPNSPYMRTLLDSIAYGHRLIPYDWEILAKSSLSP
SQFLQFKTWWIDGVQEQVRRNRAANPPVNIDADQLLGIGQNWSTISQQALMQNEAIEQVR
AICLRAWEKIQDPGSACPSFNTVRQGSKEPYPDFVARLQDVAQKSIADEKARKVIVELMA
YENANPECQSAIKPLKGKVPAGSDVISEYVKACDGIGGAMHKAMLMAQAITGVVLGGQVR
TFGGKCYNCGQIGHLKKNCPVLNKQNITIQATTTGREPPDLCPRCKKGKHWASQCRSKFD
KNGQPLSGNEQRGQPQAPQQTGAFPIQPFVPQGFQGQQPPLSQVFQGISQLPQYNNCPLP
QAAVQQ
Sequence length 666
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61581
Protein name Endogenous retrovirus group K member 24 Np9 protein (HERV-K101 Np9 protein) (HERV-K_22q11.21 provirus Np9 protein)
Protein function May possess a function in tumorigenesis.
Family and domains
Tissue specificity TISSUE SPECIFICITY: Transcript detectable in many tumor cell lines and tumor tissues.
Sequence 
MNPSEMQRKGPPRRWCLQVYPTAPKRQRPSRTGHDDDGGFVEKKRGKCGEKQERSDCYCV
CVERSRHRRLHFVMC
Sequence length 75
Interactions View interactions

No strongly related genes found yet for ERVK-24.

No additional diseases found yet through genes similar to ERVK-24.