ERVK-21 (endogenous retrovirus group K member 21, envelope)

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Gene Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 100616103
• Gene name: Endogenous retrovirus group K member 21, envelope
• Gene symbol: ERVK-21
• Synonyms (NCBI Gene): Endo-Rev2, PR, Protease, Proteinase, c12_A, envK1
• Chromosome: 12
• Chromosome location: 12q14.1

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000768	Process	Syncytium formation by plasma membrane fusion	IDA	14557543
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0004190	Function	Aspartic-type endopeptidase activity	IEA
GO:0005198	Function	Structural molecule activity	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0016032	Process	Viral process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051028	Process	MRNA transport	IEA
GO:0075523	Process	Viral translational frameshifting	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: N/A

Protein

• UniProt ID: P61565
• Protein name: Endogenous retrovirus group K member 21 Env polyprotein (EnvK1 protein) (Envelope polyprotein) (HERV-K_12q14.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]
• Protein function: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has los
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00517	GP41	485 → 681		Family
  PF13804	HERV-K_env_2	114 → 282		Domain
  PF15695	HERV-K_REC	19 → 104		Family

• Sequence:

  MHPSEMQRKAPPRRRRHRNRAPLTHKMNKMVTSEQMKLPSTKKAEPPTWAQLKKLTQLAT
  KYLENTKVTQTPESMLLAALMIVSMVVSLPMPAGAAAANYTNWAYVPFPPLIRAVTWMDN
  PIEVYVNDSVWVHGPIDDRCPAKPEEEGMMINISIGYHYPPICLGRAPGCLMPAVQNWLV
  EVPTVSPISRFTYNMVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVL
  VWEECVANSVVILQNNEFGTIIDWAPRGQFYHNCSGQTQSCPSAQVSPAVDSDLTESLDK
  HKHKKLQSFYPWEWGEKGISTPRPKIISPVSGPEHPELWRLTVASHHIRIWSGNQTLETR
  DRKPFYTVDLNSSLTVPLQSCVKPPYMLVVGNIVIKPDSQTITCENCRLLTCIDSTFNWQ
  HRILLVRAREGVWIPVSMDRPWEASPSIHILTEVLKGVLNRSKRFIFTLIAVIMGLIAVT
  AMAAVAGVALHSFVQSVNFVNDWQKNSTRLWNSQSSIDQKLANQINDLRQTVIWMGDRLM
  SLEHRFQLQCDWNTSDFCITPQIYNESEHHWDMVRRHLQGREDNLTLDISKLKEQIFEAS
  KAHLNLVPGTEAIAGVADGLANLNPVTWVKTIGSTTIINLILILVCLFCLLLVCRCTQQL
  RRDSDHRERAMMTMVVLSKRKGGNVGKSKRDQIVTVSV

• Sequence length: 698
• UniProt ID: P62683
• Protein name: Endogenous retrovirus group K member 21 Gag polyprotein (HERV-K_12q14.1 provirus ancestral Gag polyprotein) (Gag polyprotein)
• Protein function: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form mem
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00098	zf-CCHC	544 → 561	Zinc knuckle	Domain
  PF00607	Gag_p24	312 → 512		Family
  PF02337	Gag_p10	11 → 93		Family
  PF14787	zf-CCHC_5	578 → 613		Domain

• Sequence:

  MGQTKSKIKSKYASYLSFIKILLKRGGVKVSTKNLIKLFQIIEQFCPWFPEQGTLDLKDW
  KRIGKELKQAGRKGNIIPLTVWNDWAIIKAALEPFQTEEDSISVSDAPGSCIIDCNENTR
  KKSQKETEGLHCEYAAEPVMAQSTQNVDYNQLQEVIYPETLKLEGKGPELVGPSESKPRG
  TSPLPAGQVPVTLQPQTQVKENKTQPPVAYQYWPPAELQYRPPPESQYGYPGMPPAPQGR
  APYPQPPTRRLNPTAPPSRQGSELHEIIDKSRKEGDTEAWQFPVMLEPMPPGEGAQEGEP
  PTVEARYKSFSIKMLKDMKEGVKQYGPNSPYMRTLLDSIAHGHRLIPYDWEILAKSSLLP
  SQFLQFKTWWIDGVQEQVQRNRAANPPVNIDADQLLGIGQNWSTISQQALMQNEAIEQVR
  AICLRAWEKIQDPGSTCPSFNTVRQSSKEPYPDFVARLQDVAQKSIADEKARKVIVELMA
  YENANPECQSAIKPLKGKVPAGSDVISEYVKACDGIGGAMHKAMLMAQAITGVVLGGQVR
  TFGGKCYNCGQIGHLKKNCPVLNKQNITIQATTTGREPPDLCPRCKKGKHWASQCRSKFD
  KNGQPLSGNEQRGQPQAPQQTGAFPIQPFVPQGFQGQQPPLSQVFQGISQLPQYNNCPPP
  QAAVQQ

• Sequence length: 666
• UniProt ID: P63119
• Protein name: Endogenous retrovirus group K member 21 Pro protein (HERV-K_12q14.1 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)
• Protein function: Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00077	RVP	6 → 105		Domain
  PF01585	G-patch	111 → 155	G-patch domain	Family

• Sequence:

  WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGIGTASE
  VYQSTEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPTPLYSPTSQKIMT
  KMGYIPGKGLGKNEDGIKVPVEAKINQKREGIGYPF

• Sequence length: 156
• UniProt ID: P61571
• Protein name: Endogenous retrovirus group K member 21 Rec protein (HERV-K_12q14.1 provirus Rec protein)
• Protein function: Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15695	HERV-K_REC	19 → 104		Family

• Sequence:

  MHPSEMQRKAPPRRRRHRNRAPLTHKMNKMVTSEQMKLPSTKKAEPPTWAQLKKLTQLAT
  KYLENTKVTQTPESMLLAALMIVSMVSAGVPNSSEETATIENGP

• Sequence length: 104

Related Genes

No strongly related genes found yet for ERVK-21.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ERVK-21.