Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	100862688
Gene name	Endogenous retrovirus group K member 11
Gene symbol	ERVK-11
Synonyms (NCBI Gene)	N8.4c3_Epolymerase
Chromosome	3
Chromosome location	3q27.2

20 Show/Hide all (20)

GO ID	Ontology	Definition	Evidence
GO:0000731	Process	DNA synthesis involved in DNA repair	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0003964	Function	RNA-directed DNA polymerase activity	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0004523	Function	RNA-DNA hybrid ribonuclease activity	IEA
GO:0006261	Process	DNA-templated DNA replication	IEA
GO:0006278	Process	RNA-templated DNA biosynthetic process	IEA
GO:0006310	Process	DNA recombination	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0015074	Process	DNA integration	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0034061	Function	DNA polymerase activity	IEA
GO:0035613	Function	RNA stem-loop binding	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0075523	Process	Viral translational frameshifting	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	N/A

Q9UQG0

Protein name

Endogenous retrovirus group K member 11 Pol protein (HERV-K_3q27.2 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]

Protein function

Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA p

PDB

7SR6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00075	RNase_H	461 → 590	RNase H	Domain
PF00078	RVT_1	76 → 245	Reverse transcriptase (RNA-dependent DNA polymerase)	Family
PF00665	rve	644 → 739		Domain
PF02022	Integrase_Zn	592 → 629		Domain
PF06817	RVT_thumb	252 → 317		Domain
PF13804	HERV-K_env_2	875 → 969		Domain
PF00552	IN_DBD_C	813 → 857		Domain

Sequence

NKSRKRRNRVSFLGAATVEPPKPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKG
HIEPSFSPWNSPVFVIQKKSGKWRMLTDLRAVNAVIQPMGPLQPGLPSPAMIPKDWPLII
IDLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTICQTFVGRAL
QPVREKFSDCYIIHYIDDILCAAETKDKLIDCYTFLQAEVANAGLAIASDKIQTSTPFHY
LGMQIENRKIKPQKIEIRKDTLKTLNDFQKLLGDINWIRPTLGIPTYAMSNLFSILRGDS
DLNSKRILTPEATKEIKLVEEKIQSAQINRIDPLAPLQLLIFATAHSPTGIIIQNTDLVE
WSFLPHSTVKTFTLYLDQIATLIGQTRLRIIKLCGNDPDKIVVPLTKEQVRQAFINSGAW
QIGLANFVGIIDNHYPKTKIFQFLKMTTWILPKITRREPLENALTVFTDGSSNGKAAYTG
PKERVIKTPYQSAQRAELVAVITVLQDFDQPINIISDSAYVVQATRDVETALIKYSMDDQ
LNQLFNLLQQTVRKRNFPFYITHIRAHTNLPGPLTKANEEADLLVSSALIKAQELHALTH
VNAAGLKNKFDVTWKQAKDIVQHCTQCQVLHLPTQEAGVNPRGLCPNALWQMDVTHVPSF
GRLSYVHVTVDTYSHFIWATCQTGESTSHVKKHLLSCFAVMGVPEKIKTDNGPGYCSKAF
QKFLSQWKISHTTGIPYNSQGQAIVERTNRTLKTQLVKQKEGGDSKECTTPQMQLNLALY
TLNFLNIYRNQTTTSAEQHLTGKKNSPHEGKLIWWKDNKNKTWEIGKVITWGRGFACVSP
GENQLPVWIPTRHLKFYNEPIGDAKKRASTEMVTPVTWMDNPIEVYVNDSVWVPGPTDDR
CPAKPEEEGMMINISIGYRYPPICLGRAPGCLMPTVQNWLVEVPIVSPICRFTYHMVSGM
SLRPRVNYL

Sequence length

969

Interactions

View interactions

Related Genes Genes most often co-reported with ERVK-11 across shared curated disease and pathway associations. 0 Download as csv Download as pdf
No strongly related genes found yet for ERVK-11.

Diseases Linked via Similar Genes Diseases curated for genes most similar to ERVK-11 (see Related Genes above), that are NOT already directly curated for ERVK-11 itself -- a lead worth checking, not a confirmed association. 0 Download as csv Download as pdf
No additional diseases found yet through genes similar to ERVK-11.

ERVK-11 (endogenous retrovirus group K member 11)

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