ERVK-10 (endogenous retrovirus group K member 10)

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Gene Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 100616101
• Gene name: Endogenous retrovirus group K member 10
• Gene symbol: ERVK-10
• Synonyms (NCBI Gene): PR, Protease, Proteinase
• Chromosome: 5
• Chromosome location: 5q33.3

Gene ontology (GO) Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000731	Process	DNA synthesis involved in DNA repair	IEA
GO:0003674	Function	Molecular_function	ND
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0003964	Function	RNA-directed DNA polymerase activity	IEA
GO:0004190	Function	Aspartic-type endopeptidase activity	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0004523	Function	RNA-DNA hybrid ribonuclease activity	IEA
GO:0005198	Function	Structural molecule activity	IEA
GO:0005575	Component	Cellular_component	ND
GO:0005634	Component	Nucleus	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006261	Process	DNA-templated DNA replication	IEA
GO:0006278	Process	RNA-templated DNA biosynthetic process	IEA
GO:0006310	Process	DNA recombination	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0008150	Process	Biological_process	ND
GO:0008233	Function	Peptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0015074	Process	DNA integration	IEA
GO:0016020	Component	Membrane	IEA
GO:0016032	Process	Viral process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0034061	Function	DNA polymerase activity	IEA
GO:0035613	Function	RNA stem-loop binding	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0075523	Process	Viral translational frameshifting	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: N/A

Protein

• UniProt ID: P10265
• Protein name: Endogenous retrovirus group K member 10 Pro protein (HERV-K10 Pro protein) (HERV-K107 Pro protein) (HERV-K_5q33.3 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)
• Protein function: Retroviral proteases have roles in processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution. This endogenous protein
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00077	RVP	6 → 105		Domain
  PF01585	G-patch	111 → 155	G-patch domain	Family

• Sequence:

  WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGIGTASE
  VYQSMEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPAPLYSPTSQKIMT
  KMGYIPGKGLGKNEDGIKVPVEAKINQEREGIGYPF

• Sequence length: 156
• UniProt ID: P10266
• Protein name: Endogenous retrovirus group K member 10 Pol protein (HERV-K10 Pol protein) (HERV-K107 Pol protein) (HERV-K_5q33.3 provirus ancestral Pol protein) [Includes: Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN)]
• Protein function: Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA p
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00075	RNase_H	461 → 590	RNase H	Domain
  PF00078	RVT_1	76 → 245	Reverse transcriptase (RNA-dependent DNA polymerase)	Family
  PF00665	rve	644 → 739		Domain
  PF02022	Integrase_Zn	592 → 629		Domain
  PF06817	RVT_thumb	252 → 317		Domain
  PF13804	HERV-K_env_2	875 → 1014		Domain
  PF00552	IN_DBD_C	813 → 857		Domain

• Sequence:

  NKSRKRRNRVSFLGAVTVEPPKPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKG
  HIEPSFSPWNSPVFVIQKKSGKWHTLTDLRAVNAVIQPMGPLQPGLPSPAMIPKDWPLII
  IDLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTICQTFVGRAL
  QPVREKFSDCYIIHYIDDILCAAETKDKLIDCYTFLQAEVANAGLAIASDKIQTSTPFHY
  LGMQIENRKIKPQKIEIRKDTLKTLNDFQKLLGDINWIRPTLGIPTYAMSNLFSILRGDS
  DLNSQRILTPEATKEIKLVEEKIQSAQINRIDPLAPLQLLIFATAHSPTGIIIQNTDLVE
  WSFLPHSTVKTFTLYLDQIATLIGQTRLRITKLCGNDPDKIVVPLTKEQVRQAFINSGAW
  QIGLANFVGLIDNHYPKTKIFQFLKLTTWILPKITRREPLENALTVFTDGSSNGKAAYTG
  PKERVIKTPYQSAQRDELVAVITVLQDFDQPINIISDSAYVVQATRDVETALIKYSMDDQ
  LNQLFNLLQQTVRKRNFPFYITYIRAHTNLPGPLTKANEQADLLVSSALIKAQELHALTH
  VNAAGLKNKFDVTWKQAKDIVQHCTQCQVLHLPTQEAGVNPRGLCPNALWQMDVTHVPSF
  GRLSYVHVTVDTYSHFIWATCQTGESTSHVKKHLLSCFAVMGVPEKIKTDNGPGYCSKAF
  QKFLSQWKISHTTGIPYNSQGQAIVERTNRTLKTQLVKQKEGGDSKECTTPQMQLNLALY
  TLNFLNIYRNQTTTSAEQHLTGKKNSPHEGKLIWWKDNKNKTWEIGKVITWGRGFACVSP
  GENQLPVWLPTRHLKFYNEPIGDAKKRASTEMVTPVTWMDNPIEVYVNDSIWVPGPIDDR
  CPAKPEEEGMMINISIGYRYPPICLGRAPGCLMPAVQNWLVEVPTVSPISRFTYHMVSGM
  SLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVIL

• Sequence length: 1014
• UniProt ID: P87889
• Protein name: Endogenous retrovirus group K member 10 Gag polyprotein (HERV-K10 Gag protein) (HERV-K107 Gag protein) (HERV-K_5q33.3 provirus ancestral Gag polyprotein) (Gag polyprotein)
• Protein function: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form mem
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00098	zf-CCHC	544 → 561	Zinc knuckle	Domain
  PF00607	Gag_p24	312 → 512		Family
  PF02337	Gag_p10	11 → 93		Family
  PF14787	zf-CCHC_5	578 → 613		Domain

• Sequence:

  MGQTKSKIKSKYASYLSFIKILLKRGGVKVSTKNLIKLFQIIEQFCPWFPEQGTSDLKDW
  KRIGKELKQAGRKGNIIPLTVWNDWAIIKAALEPFQTEEDSISVSDAPGSCLIDCNENTR
  KKSQKETESLHCEYVAEPVMAQSTQNVDYNQLQEVIYPETLKLEGKGPELMGPSESKPRG
  TSPLPAGQVLVRLQPQKQVKENKTQPQVAYQYWPLAELQYRPPPESQYGYPGMPPAPQGR
  APYHQPPTRRLNPMAPPSRQGSELHEIIDKSRKEGDTEAWQFPVTLEPMPPGEGAQEGEP
  PTVEARYKSFSIKMLKDMKEGVKQYGPNSPYMRTLLDSIAYGHRLIPYDWEILAKSSLSP
  SQFLQFKTWWIDGVQEQVRRNRAANPPVNIDADQLLGIGQNWSTISQQALMQNEAIEQVR
  AICLRAWEKIQDPGSTCPSFNTVRQGSKEPYPDFVARLQDVAQKSIADEKAGKVIVELMA
  YENANPECQSAIKPLKGKVPAGSDVISEYVKACDGIGGAMHKAMLMAQAITGVVLGGQVR
  TFGGKCYNCGQIGHLKKNCPVLNKQNITIQATTTGREPPDLCPRCKKGKHWASQCRSKFD
  KNGQPLSGNEQRGQPQAPQQTGAFPIQPFVPQGFQGQQPPLSQVFQGISQLPQYNNCPSP
  QAAVQQ

• Sequence length: 666
• UniProt ID: P61580
• Protein name: Endogenous retrovirus group K member 10 Np9 protein (HERV-K10 Np9 protein) (HERV-K107 Np9 protein) (HERV-K_5q33.3 provirus Np9 protein)
• Protein function: May possess a function in tumorigenesis.
• Sequence:

  MNPSEMQRKGPPRRWCLQVYPTAPKRQRPSRTGHDDDGGFVEKKRGKCGEKQERSNCYCV
  CVERSRHRRLHFVMC

• Sequence length: 75

Related Genes

No strongly related genes found yet for ERVK-10.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ERVK-10.