EPPIN (epididymal peptidase inhibitor)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 57119
• Gene name: Epididymal peptidase inhibitor
• Gene symbol: EPPIN
• Synonyms (NCBI Gene): CT71, CT72, SPINLW1, WAP7, WFDC7, dJ461P17.2
• Chromosome: 20
• Chromosome location: 20q13.12
• Summary: This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telo

miRNA Show/Hide all (39)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029867	hsa-miR-26b-5p	Microarray	19088304
MIRT642639	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT642637	hsa-miR-3183	HITS-CLIP	23824327
MIRT642636	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT642635	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT661286	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT642634	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT642633	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT642632	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT642631	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT661285	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT642639	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT642638	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT642637	hsa-miR-3183	HITS-CLIP	23824327
MIRT642636	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT642635	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT642634	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT642633	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT642632	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT642631	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT642639	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT642637	hsa-miR-3183	HITS-CLIP	23824327
MIRT642636	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT642635	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT661286	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT642634	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT642633	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT642632	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT642631	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT661285	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT642639	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT642638	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT642637	hsa-miR-3183	HITS-CLIP	23824327
MIRT642636	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT642635	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT642634	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT642633	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT642632	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT642631	hsa-miR-6881-3p	HITS-CLIP	23824327

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IEA
GO:0005515	Function	Protein binding	IPI	15590901, 17567961, 19889947
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	17567961
GO:0005737	Component	Cytoplasm	IEA
GO:0009986	Component	Cell surface	IDA	17567961
GO:0009986	Component	Cell surface	IEA
GO:0010466	Process	Negative regulation of peptidase activity	IDA	18331357
GO:0030414	Function	Peptidase inhibitor activity	IEA
GO:0032991	Component	Protein-containing complex	IDA	17567961
GO:0042742	Process	Defense response to bacterium	IDA	18331357
GO:0090281	Process	Negative regulation of calcium ion import	IMP	22075473
GO:0097524	Component	Sperm plasma membrane	TAS
GO:1901318	Process	Negative regulation of flagellated sperm motility	IBA
GO:1901318	Process	Negative regulation of flagellated sperm motility	IMP	22075473

Other IDs

• MIM: 609031
• HGNC: 15932
• e!Ensembl: ENSG00000101448

Protein

• UniProt ID: O95925
• Protein name: Eppin (Cancer/testis antigen 71) (CT71) (Epididymal protease inhibitor) (Protease inhibitor WAP7) (Serine protease inhibitor-like with Kunitz and WAP domains 1) (WAP four-disulfide core domain protein 7)
• Protein function: Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00014	Kunitz_BPTI	76 → 128	Kunitz/Bovine pancreatic trypsin inhibitor domain	Domain
  PF00095	WAP	29 → 72		Domain

• Tissue specificity: TISSUE SPECIFICITY: In testis, expressed and secreted by Sertoli cells, appearing on the surface of testicular and ejaculate spermatozoa. Expressed in the spermatogonia and the earliest preleptotene spermatocytes. In the epididymis, is expressed and secre
• Sequence:

  MGSSGLLSLLVLFVLLANVQGPGLTDWLFPRRCPKIREECEFQERDVCTKDRQCQDNKKC
  CVFSCGKKCLDLKQDVCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQGNNNNFQSK
  ANCLNTCKNKRFP

• Sequence length: 133

Pathways

Reactome Pathway:

Antimicrobial peptides

Related Genes

No strongly related genes found yet for EPPIN.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to EPPIN.