ENPP4 (ectonucleotide pyrophosphatase/phosphodiesterase 4)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 22875
• Gene name: Ectonucleotide pyrophosphatase/phosphodiesterase 4
• Gene symbol: ENPP4
• Synonyms (NCBI Gene): NPP4
• Chromosome: 6
• Chromosome location: 6p21.1

miRNA Show/Hide all (232)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024537	hsa-miR-215-5p	Microarray	19074876
MIRT026249	hsa-miR-192-5p	Microarray	19074876
MIRT027007	hsa-miR-103a-3p	Sequencing	20371350
MIRT031579	hsa-miR-16-5p	Sequencing	20371350
MIRT100791	hsa-miR-3666	PAR-CLIP	21572407
MIRT100768	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT100770	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT100769	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT100783	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT100789	hsa-miR-4295	PAR-CLIP	21572407
MIRT100782	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT100775	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT100774	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT100773	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT100798	hsa-miR-4517	PAR-CLIP	21572407
MIRT558137	hsa-miR-6888-5p	PAR-CLIP	21572407
MIRT169254	hsa-miR-4324	PAR-CLIP	21572407
MIRT558136	hsa-miR-544b	PAR-CLIP	21572407
MIRT169251	hsa-miR-3124-3p	PAR-CLIP	21572407
MIRT558135	hsa-miR-4795-5p	PAR-CLIP	21572407
MIRT558134	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT558133	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT558132	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT558131	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT558130	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT100762	hsa-miR-30a-5p	PAR-CLIP	21572407
MIRT100767	hsa-miR-30b-5p	PAR-CLIP	21572407
MIRT100763	hsa-miR-30c-5p	PAR-CLIP	21572407
MIRT100764	hsa-miR-30d-5p	PAR-CLIP	21572407
MIRT100771	hsa-miR-30e-5p	PAR-CLIP	21572407
MIRT100760	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT100761	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT100785	hsa-miR-1258	PAR-CLIP	21572407
MIRT558129	hsa-miR-4266	PAR-CLIP	21572407
MIRT558128	hsa-miR-378a-5p	PAR-CLIP	21572407
MIRT169250	hsa-miR-1200	PAR-CLIP	21572407
MIRT100790	hsa-miR-3616-5p	PAR-CLIP	21572407
MIRT100777	hsa-miR-573	PAR-CLIP	21572407
MIRT169268	hsa-miR-548aw	PAR-CLIP	21572407
MIRT558127	hsa-miR-3074-5p	PAR-CLIP	21572407
MIRT558126	hsa-miR-7152-5p	PAR-CLIP	21572407
MIRT558125	hsa-miR-552-5p	PAR-CLIP	21572407
MIRT440724	hsa-miR-205-5p	HITS-CLIP	22473208
MIRT100760	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT100761	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT440724	hsa-miR-205-5p	HITS-CLIP	22473208
MIRT100762	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT100767	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT100763	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT100764	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT100771	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT100791	hsa-miR-3666	PAR-CLIP	21572407
MIRT100768	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT100770	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT100769	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT100783	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT100789	hsa-miR-4295	PAR-CLIP	21572407
MIRT100782	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT100775	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT100774	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT100773	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT100798	hsa-miR-4517	PAR-CLIP	21572407
MIRT558137	hsa-miR-6888-5p	PAR-CLIP	21572407
MIRT169254	hsa-miR-4324	PAR-CLIP	21572407
MIRT558136	hsa-miR-544b	PAR-CLIP	21572407
MIRT169251	hsa-miR-3124-3p	PAR-CLIP	21572407
MIRT558135	hsa-miR-4795-5p	PAR-CLIP	21572407
MIRT558134	hsa-miR-548aj-5p	PAR-CLIP	21572407
MIRT558133	hsa-miR-548f-5p	PAR-CLIP	21572407
MIRT558132	hsa-miR-548g-5p	PAR-CLIP	21572407
MIRT558131	hsa-miR-548x-5p	PAR-CLIP	21572407
MIRT558130	hsa-miR-1468-3p	PAR-CLIP	21572407
MIRT100762	hsa-miR-30a-5p	PAR-CLIP	21572407
MIRT100767	hsa-miR-30b-5p	PAR-CLIP	21572407
MIRT100763	hsa-miR-30c-5p	PAR-CLIP	21572407
MIRT100764	hsa-miR-30d-5p	PAR-CLIP	21572407
MIRT100771	hsa-miR-30e-5p	PAR-CLIP	21572407
MIRT100760	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT100761	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT100785	hsa-miR-1258	PAR-CLIP	21572407
MIRT558129	hsa-miR-4266	PAR-CLIP	21572407
MIRT558128	hsa-miR-378a-5p	PAR-CLIP	21572407
MIRT169250	hsa-miR-1200	PAR-CLIP	21572407
MIRT100790	hsa-miR-3616-5p	PAR-CLIP	21572407
MIRT100777	hsa-miR-573	PAR-CLIP	21572407
MIRT169268	hsa-miR-548aw	PAR-CLIP	21572407
MIRT558127	hsa-miR-3074-5p	PAR-CLIP	21572407
MIRT558126	hsa-miR-7152-5p	PAR-CLIP	21572407
MIRT558125	hsa-miR-552-5p	PAR-CLIP	21572407
MIRT964027	hsa-miR-146a	CLIP-seq
MIRT964028	hsa-miR-146b-5p	CLIP-seq
MIRT964029	hsa-miR-3159	CLIP-seq
MIRT964030	hsa-miR-329	CLIP-seq
MIRT964031	hsa-miR-361-5p	CLIP-seq
MIRT964032	hsa-miR-362-3p	CLIP-seq
MIRT964033	hsa-miR-4264	CLIP-seq
MIRT964034	hsa-miR-4302	CLIP-seq
MIRT964035	hsa-miR-4509	CLIP-seq
MIRT964036	hsa-miR-4729	CLIP-seq
MIRT964037	hsa-miR-4797-3p	CLIP-seq
MIRT964038	hsa-miR-488	CLIP-seq
MIRT964039	hsa-miR-513a-3p	CLIP-seq
MIRT964040	hsa-miR-579	CLIP-seq
MIRT964041	hsa-miR-580	CLIP-seq
MIRT964042	hsa-miR-589	CLIP-seq
MIRT964043	hsa-miR-651	CLIP-seq
MIRT964044	hsa-miR-889	CLIP-seq
MIRT1985729	hsa-miR-1323	CLIP-seq
MIRT1985730	hsa-miR-3120-5p	CLIP-seq
MIRT1985731	hsa-miR-346	CLIP-seq
MIRT1985732	hsa-miR-3646	CLIP-seq
MIRT1985733	hsa-miR-3714	CLIP-seq
MIRT1985734	hsa-miR-4288	CLIP-seq
MIRT1985735	hsa-miR-4424	CLIP-seq
MIRT1985736	hsa-miR-4539	CLIP-seq
MIRT1985737	hsa-miR-4652-3p	CLIP-seq
MIRT1985738	hsa-miR-466	CLIP-seq
MIRT1985739	hsa-miR-495	CLIP-seq
MIRT1985740	hsa-miR-520d-5p	CLIP-seq
MIRT1985741	hsa-miR-524-5p	CLIP-seq
MIRT1985742	hsa-miR-548n	CLIP-seq
MIRT1985743	hsa-miR-548o	CLIP-seq
MIRT1985744	hsa-miR-548t	CLIP-seq
MIRT964040	hsa-miR-579	CLIP-seq
MIRT1985745	hsa-miR-632	CLIP-seq
MIRT1985746	hsa-miR-760	CLIP-seq
MIRT1985747	hsa-miR-767-3p	CLIP-seq
MIRT2220224	hsa-miR-153	CLIP-seq
MIRT1985733	hsa-miR-3714	CLIP-seq
MIRT2220225	hsa-miR-4269	CLIP-seq
MIRT2220226	hsa-miR-4457	CLIP-seq
MIRT2220227	hsa-miR-448	CLIP-seq
MIRT2220228	hsa-miR-4645-3p	CLIP-seq
MIRT2220229	hsa-miR-4719	CLIP-seq
MIRT2220230	hsa-miR-4731-3p	CLIP-seq
MIRT2220231	hsa-miR-4801	CLIP-seq
MIRT2220232	hsa-miR-513b	CLIP-seq
MIRT2220233	hsa-miR-570	CLIP-seq
MIRT2220234	hsa-miR-940	CLIP-seq
MIRT2387429	hsa-miR-582-3p	CLIP-seq
MIRT2448865	hsa-miR-105	CLIP-seq
MIRT2448866	hsa-miR-3119	CLIP-seq
MIRT2448867	hsa-miR-3155	CLIP-seq
MIRT2448868	hsa-miR-3155b	CLIP-seq
MIRT2448869	hsa-miR-484	CLIP-seq
MIRT2448870	hsa-miR-522	CLIP-seq
MIRT2524082	hsa-miR-1208	CLIP-seq
MIRT2524083	hsa-miR-1228	CLIP-seq
MIRT2524084	hsa-miR-1253	CLIP-seq
MIRT2524085	hsa-miR-1279	CLIP-seq
MIRT2524086	hsa-miR-2116	CLIP-seq
MIRT2524087	hsa-miR-219-1-3p	CLIP-seq
MIRT2524088	hsa-miR-28-3p	CLIP-seq
MIRT2524089	hsa-miR-3143	CLIP-seq
MIRT2524090	hsa-miR-3154	CLIP-seq
MIRT2524091	hsa-miR-3163	CLIP-seq
MIRT2524092	hsa-miR-337-3p	CLIP-seq
MIRT2524093	hsa-miR-3613-3p	CLIP-seq
MIRT2524094	hsa-miR-3650	CLIP-seq
MIRT2524095	hsa-miR-3667-3p	CLIP-seq
MIRT2524096	hsa-miR-3910	CLIP-seq
MIRT2524097	hsa-miR-3976	CLIP-seq
MIRT2524098	hsa-miR-410	CLIP-seq
MIRT2524099	hsa-miR-4252	CLIP-seq
MIRT2524100	hsa-miR-4273	CLIP-seq
MIRT2524101	hsa-miR-4436a	CLIP-seq
MIRT2524102	hsa-miR-4480	CLIP-seq
MIRT2524103	hsa-miR-4484	CLIP-seq
MIRT2524104	hsa-miR-4503	CLIP-seq
MIRT2524105	hsa-miR-4659a-3p	CLIP-seq
MIRT2524106	hsa-miR-4659b-3p	CLIP-seq
MIRT2524107	hsa-miR-4668-3p	CLIP-seq
MIRT2524108	hsa-miR-4677-5p	CLIP-seq
MIRT2524109	hsa-miR-4700-3p	CLIP-seq
MIRT2524110	hsa-miR-4705	CLIP-seq
MIRT2524111	hsa-miR-4708-3p	CLIP-seq
MIRT2524112	hsa-miR-4714-3p	CLIP-seq
MIRT2524113	hsa-miR-4724-3p	CLIP-seq
MIRT2524114	hsa-miR-4738-3p	CLIP-seq
MIRT2524115	hsa-miR-4753-3p	CLIP-seq
MIRT2524116	hsa-miR-4760-5p	CLIP-seq
MIRT2524117	hsa-miR-4762-3p	CLIP-seq
MIRT2524118	hsa-miR-4766-5p	CLIP-seq
MIRT2524119	hsa-miR-4775	CLIP-seq
MIRT2524120	hsa-miR-4778-5p	CLIP-seq
MIRT2524121	hsa-miR-4790-3p	CLIP-seq
MIRT2524122	hsa-miR-4803	CLIP-seq
MIRT964039	hsa-miR-513a-3p	CLIP-seq
MIRT2524123	hsa-miR-548a-3p	CLIP-seq
MIRT2524124	hsa-miR-548an	CLIP-seq
MIRT2524125	hsa-miR-548e	CLIP-seq
MIRT2524126	hsa-miR-548f	CLIP-seq
MIRT2524127	hsa-miR-571	CLIP-seq
MIRT2387429	hsa-miR-582-3p	CLIP-seq
MIRT2524128	hsa-miR-590-3p	CLIP-seq
MIRT2524129	hsa-miR-593	CLIP-seq
MIRT2524130	hsa-miR-634	CLIP-seq
MIRT2524082	hsa-miR-1208	CLIP-seq
MIRT2524084	hsa-miR-1253	CLIP-seq
MIRT2680082	hsa-miR-1587	CLIP-seq
MIRT2524086	hsa-miR-2116	CLIP-seq
MIRT2448867	hsa-miR-3155	CLIP-seq
MIRT2448868	hsa-miR-3155b	CLIP-seq
MIRT2524091	hsa-miR-3163	CLIP-seq
MIRT2680083	hsa-miR-3182	CLIP-seq
MIRT2524092	hsa-miR-337-3p	CLIP-seq
MIRT2680084	hsa-miR-378g	CLIP-seq
MIRT2524096	hsa-miR-3910	CLIP-seq
MIRT2524097	hsa-miR-3976	CLIP-seq
MIRT2524098	hsa-miR-410	CLIP-seq
MIRT2524100	hsa-miR-4273	CLIP-seq
MIRT2680085	hsa-miR-4427	CLIP-seq
MIRT2220227	hsa-miR-448	CLIP-seq
MIRT2524103	hsa-miR-4484	CLIP-seq
MIRT2680086	hsa-miR-4492	CLIP-seq
MIRT2680087	hsa-miR-4498	CLIP-seq
MIRT2524104	hsa-miR-4503	CLIP-seq
MIRT2680088	hsa-miR-4656	CLIP-seq
MIRT2524105	hsa-miR-4659a-3p	CLIP-seq
MIRT2524106	hsa-miR-4659b-3p	CLIP-seq
MIRT2524107	hsa-miR-4668-3p	CLIP-seq
MIRT2680089	hsa-miR-4675	CLIP-seq
MIRT2524108	hsa-miR-4677-5p	CLIP-seq
MIRT2680090	hsa-miR-4680-3p	CLIP-seq
MIRT2680091	hsa-miR-4741	CLIP-seq
MIRT2524115	hsa-miR-4753-3p	CLIP-seq
MIRT2680092	hsa-miR-4795-3p	CLIP-seq
MIRT2448869	hsa-miR-484	CLIP-seq
MIRT2524124	hsa-miR-548an	CLIP-seq
MIRT2387429	hsa-miR-582-3p	CLIP-seq
MIRT2524129	hsa-miR-593	CLIP-seq
MIRT2680093	hsa-miR-762	CLIP-seq

Gene ontology (GO) Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007596	Process	Blood coagulation	IEA
GO:0007599	Process	Hemostasis	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030194	Process	Positive regulation of blood coagulation	IDA	22995898
GO:0046130	Process	Purine ribonucleoside catabolic process	IDA	22995898
GO:0046872	Function	Metal ion binding	IEA
GO:0047710	Function	Bis(5'-adenosyl)-triphosphatase activity	IBA
GO:0047710	Function	Bis(5'-adenosyl)-triphosphatase activity	IDA	22995898
GO:0047710	Function	Bis(5'-adenosyl)-triphosphatase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0101003	Component	Ficolin-1-rich granule membrane	TAS

Other IDs

• MIM: 617000
• HGNC: 3359
• e!Ensembl: ENSG00000001561

Protein

• UniProt ID: Q9Y6X5
• Protein name: Bis(5'-adenosyl)-triphosphatase ENPP4 (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 4) (E-NPP 4) (NPP-4)
• Protein function: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at th
• PDB: 4LQY , 4LR2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01663	Phosphodiest	28 → 339	Type I phosphodiesterase / nucleotide pyrophosphatase	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed on the surface of vascular endothelia. {ECO:0000269|PubMed:22995898}.
• Sequence:

  MKLLVILLFSGLITGFRSDSSSSLPPKLLLVSFDGFRADYLKNYEFPHLQNFIKEGVLVE
  HVKNVFITKTFPNHYSIVTGLYEESHGIVANSMYDAVTKKHFSDSNDKDPFWWNEAVPIW
  VTNQLQENRSSAAAMWPGTDVPIHDTISSYFMNYNSSVSFEERLNNITMWLNNSNPPVTF
  ATLYWEEPDASGHKYGPEDKENMSRVLKKIDDLIGDLVQRLKMLGLWENLNVIITSDHGM
  TQCSQDRLINLDSCIDHSYYTLIDLSPVAAILPKINRTEVYNKLKNCSPHMNVYLKEDIP
  NRFYYQHNDRIQPIILVADEGWTIVLNESSQKLGDHGYDNSLPSMHPFLAAHGPAFHKGY
  KHSTINIVDIYPMMCHILGLKPHPNNGTFGHTKCLLVDQWCINLPEAIAIVIGSLLVLTM
  LTCLIIIMQNRLSVPRPFSRLQLQEDDDDPLIG

• Sequence length: 453

Pathways

KEGG Pathway	Reactome Pathway
Purine metabolism	Neutrophil degranulation
Metabolic pathways

Related Genes

No strongly related genes found yet for ENPP4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ENPP4.