ENGASE (endo-beta-N-acetylglucosaminidase)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Diseases linked via similar genes

Gene

• Entrez ID: 64772
• Gene name: Endo-beta-N-acetylglucosaminidase
• Gene symbol: ENGASE
• Synonyms (NCBI Gene): -
• Chromosome: 17
• Chromosome location: 17q25.3
• Summary: This gene encodes a cytosolic enzyme which catalyzes the hydrolysis of peptides and proteins with mannose modifications to produce free oligosaccharides. [provided by RefSeq, Feb 2012]

miRNA Show/Hide all (99)

miRTarBase ID	miRNA	Experiments	Reference
MIRT963488	hsa-miR-1202	CLIP-seq
MIRT963489	hsa-miR-1205	CLIP-seq
MIRT963490	hsa-miR-1207-3p	CLIP-seq
MIRT963491	hsa-miR-1236	CLIP-seq
MIRT963492	hsa-miR-1291	CLIP-seq
MIRT963493	hsa-miR-129-3p	CLIP-seq
MIRT963494	hsa-miR-1909	CLIP-seq
MIRT963495	hsa-miR-1911	CLIP-seq
MIRT963496	hsa-miR-1912	CLIP-seq
MIRT963497	hsa-miR-193a-3p	CLIP-seq
MIRT963498	hsa-miR-193b	CLIP-seq
MIRT963499	hsa-miR-203	CLIP-seq
MIRT963500	hsa-miR-3130-5p	CLIP-seq
MIRT963501	hsa-miR-3157-3p	CLIP-seq
MIRT963502	hsa-miR-3162-3p	CLIP-seq
MIRT963503	hsa-miR-3194-5p	CLIP-seq
MIRT963504	hsa-miR-328	CLIP-seq
MIRT963505	hsa-miR-3691-5p	CLIP-seq
MIRT963506	hsa-miR-376c	CLIP-seq
MIRT963507	hsa-miR-3972	CLIP-seq
MIRT963508	hsa-miR-4265	CLIP-seq
MIRT963509	hsa-miR-4267	CLIP-seq
MIRT963510	hsa-miR-4290	CLIP-seq
MIRT963511	hsa-miR-4296	CLIP-seq
MIRT963512	hsa-miR-4322	CLIP-seq
MIRT963513	hsa-miR-4417	CLIP-seq
MIRT963514	hsa-miR-4418	CLIP-seq
MIRT963515	hsa-miR-4437	CLIP-seq
MIRT963516	hsa-miR-4482	CLIP-seq
MIRT963517	hsa-miR-4491	CLIP-seq
MIRT963518	hsa-miR-4657	CLIP-seq
MIRT963519	hsa-miR-4667-3p	CLIP-seq
MIRT963520	hsa-miR-4674	CLIP-seq
MIRT963521	hsa-miR-4752	CLIP-seq
MIRT963522	hsa-miR-509-3-5p	CLIP-seq
MIRT963523	hsa-miR-509-5p	CLIP-seq
MIRT963524	hsa-miR-642a	CLIP-seq
MIRT963525	hsa-miR-766	CLIP-seq
MIRT963526	hsa-miR-874	CLIP-seq
MIRT963527	hsa-miR-938	CLIP-seq
MIRT1985596	hsa-miR-1237	CLIP-seq
MIRT1985597	hsa-miR-1248	CLIP-seq
MIRT1985598	hsa-miR-1253	CLIP-seq
MIRT963495	hsa-miR-1911	CLIP-seq
MIRT963496	hsa-miR-1912	CLIP-seq
MIRT1985599	hsa-miR-198	CLIP-seq
MIRT963500	hsa-miR-3130-5p	CLIP-seq
MIRT963501	hsa-miR-3157-3p	CLIP-seq
MIRT1985600	hsa-miR-3192	CLIP-seq
MIRT1985601	hsa-miR-3649	CLIP-seq
MIRT1985602	hsa-miR-3922-5p	CLIP-seq
MIRT963510	hsa-miR-4290	CLIP-seq
MIRT1985603	hsa-miR-4314	CLIP-seq
MIRT963516	hsa-miR-4482	CLIP-seq
MIRT1985604	hsa-miR-4646-5p	CLIP-seq
MIRT963519	hsa-miR-4667-3p	CLIP-seq
MIRT1985605	hsa-miR-4731-3p	CLIP-seq
MIRT1985606	hsa-miR-4801	CLIP-seq
MIRT1985607	hsa-miR-615-5p	CLIP-seq
MIRT1985608	hsa-miR-720	CLIP-seq
MIRT963525	hsa-miR-766	CLIP-seq
MIRT963526	hsa-miR-874	CLIP-seq
MIRT963495	hsa-miR-1911	CLIP-seq
MIRT963496	hsa-miR-1912	CLIP-seq
MIRT963500	hsa-miR-3130-5p	CLIP-seq
MIRT963501	hsa-miR-3157-3p	CLIP-seq
MIRT963510	hsa-miR-4290	CLIP-seq
MIRT963516	hsa-miR-4482	CLIP-seq
MIRT963519	hsa-miR-4667-3p	CLIP-seq
MIRT2220068	hsa-miR-4691-3p	CLIP-seq
MIRT2220069	hsa-miR-513c	CLIP-seq
MIRT2220070	hsa-miR-514b-5p	CLIP-seq
MIRT963526	hsa-miR-874	CLIP-seq
MIRT963489	hsa-miR-1205	CLIP-seq
MIRT963495	hsa-miR-1911	CLIP-seq
MIRT963496	hsa-miR-1912	CLIP-seq
MIRT963500	hsa-miR-3130-5p	CLIP-seq
MIRT963501	hsa-miR-3157-3p	CLIP-seq
MIRT963510	hsa-miR-4290	CLIP-seq
MIRT2387421	hsa-miR-4456	CLIP-seq
MIRT963516	hsa-miR-4482	CLIP-seq
MIRT963519	hsa-miR-4667-3p	CLIP-seq
MIRT963526	hsa-miR-874	CLIP-seq
MIRT2448843	hsa-miR-1225-3p	CLIP-seq
MIRT2448844	hsa-miR-1343	CLIP-seq
MIRT2448845	hsa-miR-3127-3p	CLIP-seq
MIRT2448846	hsa-miR-331-3p	CLIP-seq
MIRT2448847	hsa-miR-3667-3p	CLIP-seq
MIRT2448848	hsa-miR-3679-3p	CLIP-seq
MIRT2680046	hsa-miR-1976	CLIP-seq
MIRT2680047	hsa-miR-214	CLIP-seq
MIRT2680048	hsa-miR-2467-3p	CLIP-seq
MIRT2680049	hsa-miR-3619-5p	CLIP-seq
MIRT2680050	hsa-miR-4291	CLIP-seq
MIRT2680051	hsa-miR-4419a	CLIP-seq
MIRT2680052	hsa-miR-4510	CLIP-seq
MIRT2680053	hsa-miR-4722-3p	CLIP-seq
MIRT2680054	hsa-miR-761	CLIP-seq
MIRT2680055	hsa-miR-922	CLIP-seq

Gene ontology (GO) Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004553	Function	Hydrolase activity, hydrolyzing O-glycosyl compounds	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006457	Process	Protein folding	TAS
GO:0006491	Process	N-glycan processing	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA
GO:0033925	Function	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	IBA
GO:0033925	Function	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	IDA	12114544
GO:0033925	Function	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	IEA
GO:0033925	Function	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	TAS

Other IDs

• MIM: 611898
• HGNC: 24622
• e!Ensembl: ENSG00000167280

Protein

• UniProt ID: Q8NFI3
• Protein name: Cytosolic endo-beta-N-acetylglucosaminidase (ENGase) (EC 3.2.1.96)
• Protein function: Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03644	Glyco_hydro_85	135 → 412	Glycosyl hydrolase family 85	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Expressed at higher level in thymus and spleen. {ECO:0000269|PubMed:12114544}.
• Sequence:

  MEAAAVTVTRSATRRRRRQLQGLAAPEAGTQEEQEDQEPRPRRRRPGRSIKDEEEETVFR
  EVVSFSPDPLPVRYYDKDTTKPISFYLSSLEELLAWKPRLEDGFNVALEPLACRQPPLSS
  QRPRTLLCHDMMGGYLDDRFIQGSVVQTPYAFYHWQCIDVFVYFSHHTVTIPPVGWTNTA
  HRHGVCVLGTFITEWNEGGRLCEAFLAGDERSYQAVADRLVQITQFFRFDGWLINIENSL
  SLAAVGNMPPFLRYLTTQLHRQVPGGLVLWYDSVVQSGQLKWQDELNQHNRVFFDSCDGF
  FTNYNWREEHLERMLGQAGERRADVYVGVDVFARGNVVGGRFDTDKSLELIRKHGFSVAL
  FAPGWVYECLEKKDFFQNQDKFWGRLERYLPTHSICSLPFVTSFCLGMGARRVCYGQEEA
  VGPWYHLSAQEIQPLFGEHRLGGDGRGWVRTHCCLEDAWHGGSSLLVRGVIPPEVGNVAV
  RLFSLQAPVPPKIYLSMVYKLEGPTDVTVALELTTGDAGSCHIGGISVLNAETSSRHSLR
  PLRVPPTKLARWVGRCGRQLSGGWVQHCYEVSLRGCLLLDLLVCFSRPPGSREEESFTCR
  LGEIQVVDAASLLAPLPQVQAVTISHIRWQPSASEREGPPALLQLSCTLHWSFLLSQVRC
  FRIHCWGGMSDDSPGRELPRPEMPMFLGLAFATQYRIVDLLVEAAGPGQDRRMEFLVEPV
  PKEGFRVPQAEWGRAVLLYSAPA

• Sequence length: 743

Pathways

KEGG Pathway:

Other glycan degradation

Reactome Pathway:

N-glycan trimming in the ER and Calnexin/Calreticulin cycle

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Acute myeloid leukemia	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	3543022		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	2736531, 3543022		★☆☆☆☆ Found in Text Mining only
NGLY1 deficiency	NGLY1 Deficiency	BEFREE	28426790, 28512024		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	LHGDN	12905469		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for ENGASE.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ENGASE.