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Gene Gene information from NCBI Gene database.
Entrez ID 23052
Gene name Endonuclease domain containing 1
Gene symbol ENDOD1
Synonyms (NCBI Gene)
-
Chromosome 11
Chromosome location 11q21
miRNA miRNA information provided by mirtarbase database.
326 Show/Hide all (326)
miRTarBase ID miRNA Experiments Reference
MIRT004892 hsa-miR-124-3p Microarray 15685193
MIRT016599 hsa-miR-193b-3p Microarray 20304954
MIRT004892 hsa-miR-124-3p Microarray 18668037
MIRT026848 hsa-miR-192-5p Microarray 19074876
MIRT053359 hsa-miR-9-5p MicroarrayqRT-PCR 23798388
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13 Show/Hide all (13)
GO ID Ontology Definition Evidence Reference
GO:0002376 Process Immune system process IEA
GO:0003676 Function Nucleic acid binding IEA
GO:0004518 Function Nuclease activity IEA
GO:0004519 Function Endonuclease activity IEA
GO:0005515 Function Protein binding IPI 32296183, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619568 29129 ENSG00000149218
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O94919
Protein name Endonuclease domain-containing 1 protein (EC 3.1.30.-)
Protein function May act as a DNase and a RNase. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01223 Endonuclease_NS 49 → 257 DNA/RNA non-specific endonuclease Domain
Sequence
MGTARWLALGSLFALAGLLEGRLVGEEEAGFGECDKFFYAGTPPAGLAADSHVKICQRAE
GAERFATLYSTRDRIPVYSAFRAPRPAPGGAEQRWLVEPQIDDPNSNLEEAINEAEAITS
VNSLGSKQALNTDYLDSDYQRGQLYPFSLSSDVQVATFTLTNSAPMTQSFQERWYVNLHS
LMDRALTPQCGSGEDLYILTGTVPSDYRVKDKVAVPEFVWLAACCAVPGGGWAMGFVKHT
RDSDIIEDVMVKDLQKL
LPFNPQLFQNNCGETEQDTEKMKKILEVVNQIQDEERMVQSQK
SSSPLSSTRSKRSTLLPPEASEGSSSFLGKLMGFIATPFIKLFQLIYYLVVAILKNIVYF
LWCVTKQVINGIESCLYRLGSATISYFMAIGEELVSIPWKVLKVVAKVIRALLRILCCLL
KAICRVLSIPVRVLVDVATFPVYTMGAIPIVCKDIALGLGGTVSLLFDTAFGTLGGLFQV
VFSVCKRIGYKVTFDNSGEL
Sequence length 500
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Platelet degranulation