EML6 (EMAP like 6)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 400954
• Gene name: EMAP like 6
• Gene symbol: EML6
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2p16.1

miRNA Show/Hide all (88)

miRTarBase ID	miRNA	Experiments	Reference
MIRT446357	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT446356	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT446355	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT446354	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT446353	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT446352	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT446351	hsa-miR-543	PAR-CLIP	22100165
MIRT446350	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT446349	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT446348	hsa-miR-6759-3p	PAR-CLIP	22100165
MIRT446346	hsa-miR-3143	PAR-CLIP	22100165
MIRT446347	hsa-miR-192-5p	PAR-CLIP	22100165
MIRT446345	hsa-miR-215-5p	PAR-CLIP	22100165
MIRT446344	hsa-miR-302c-5p	PAR-CLIP	22100165
MIRT446357	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT446356	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT446355	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT446354	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT446353	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT446352	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT446351	hsa-miR-543	PAR-CLIP	22100165
MIRT446350	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT446349	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT446348	hsa-miR-6759-3p	PAR-CLIP	22100165
MIRT446346	hsa-miR-3143	PAR-CLIP	22100165
MIRT446347	hsa-miR-192-5p	PAR-CLIP	22100165
MIRT446345	hsa-miR-215-5p	PAR-CLIP	22100165
MIRT446344	hsa-miR-302c-5p	PAR-CLIP	22100165
MIRT962212	hsa-miR-135a	CLIP-seq
MIRT962213	hsa-miR-135b	CLIP-seq
MIRT962214	hsa-miR-15a	CLIP-seq
MIRT962215	hsa-miR-15b	CLIP-seq
MIRT962216	hsa-miR-16	CLIP-seq
MIRT962217	hsa-miR-195	CLIP-seq
MIRT962218	hsa-miR-219-5p	CLIP-seq
MIRT962219	hsa-miR-3184	CLIP-seq
MIRT962220	hsa-miR-3942-5p	CLIP-seq
MIRT962221	hsa-miR-423-5p	CLIP-seq
MIRT962222	hsa-miR-424	CLIP-seq
MIRT962223	hsa-miR-4436a	CLIP-seq
MIRT962224	hsa-miR-4490	CLIP-seq
MIRT962225	hsa-miR-4524	CLIP-seq
MIRT962226	hsa-miR-4639-5p	CLIP-seq
MIRT962227	hsa-miR-4686	CLIP-seq
MIRT962228	hsa-miR-4703-5p	CLIP-seq
MIRT962229	hsa-miR-4774-5p	CLIP-seq
MIRT962230	hsa-miR-4782-3p	CLIP-seq
MIRT962231	hsa-miR-4788	CLIP-seq
MIRT962232	hsa-miR-4803	CLIP-seq
MIRT962233	hsa-miR-497	CLIP-seq
MIRT962234	hsa-miR-503	CLIP-seq
MIRT962235	hsa-miR-603	CLIP-seq
MIRT962236	hsa-miR-642b	CLIP-seq
MIRT962237	hsa-miR-646	CLIP-seq
MIRT1985195	hsa-miR-103a	CLIP-seq
MIRT1985196	hsa-miR-107	CLIP-seq
MIRT1985197	hsa-miR-4274	CLIP-seq
MIRT1985198	hsa-miR-486-3p	CLIP-seq
MIRT962214	hsa-miR-15a	CLIP-seq
MIRT962215	hsa-miR-15b	CLIP-seq
MIRT962216	hsa-miR-16	CLIP-seq
MIRT962217	hsa-miR-195	CLIP-seq
MIRT2219884	hsa-miR-3182	CLIP-seq
MIRT2219885	hsa-miR-3652	CLIP-seq
MIRT2219886	hsa-miR-3663-3p	CLIP-seq
MIRT962220	hsa-miR-3942-5p	CLIP-seq
MIRT962222	hsa-miR-424	CLIP-seq
MIRT2219887	hsa-miR-4276	CLIP-seq
MIRT2219888	hsa-miR-4428	CLIP-seq
MIRT2219889	hsa-miR-4430	CLIP-seq
MIRT2219890	hsa-miR-4434	CLIP-seq
MIRT2219891	hsa-miR-4505	CLIP-seq
MIRT2219892	hsa-miR-4516	CLIP-seq
MIRT962225	hsa-miR-4524	CLIP-seq
MIRT2219893	hsa-miR-4531	CLIP-seq
MIRT2219894	hsa-miR-4536	CLIP-seq
MIRT962228	hsa-miR-4703-5p	CLIP-seq
MIRT2219895	hsa-miR-4802-5p	CLIP-seq
MIRT962233	hsa-miR-497	CLIP-seq
MIRT962234	hsa-miR-503	CLIP-seq
MIRT2219896	hsa-miR-539	CLIP-seq
MIRT962237	hsa-miR-646	CLIP-seq
MIRT962214	hsa-miR-15a	CLIP-seq
MIRT962215	hsa-miR-15b	CLIP-seq
MIRT962216	hsa-miR-16	CLIP-seq
MIRT962217	hsa-miR-195	CLIP-seq
MIRT962222	hsa-miR-424	CLIP-seq
MIRT962233	hsa-miR-497	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0008017	Function	Microtubule binding	IBA

Other IDs

• MIM: 621084
• HGNC: 35412
• e!Ensembl: ENSG00000214595

Protein

• UniProt ID: Q6ZMW3
• Protein name: Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like)
• Protein function: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	314 → 353	WD domain, G-beta repeat	Repeat
  PF00400	WD40	1678 → 1715	WD domain, G-beta repeat	Repeat
  PF00400	WD40	553 → 592	WD domain, G-beta repeat	Repeat
  PF00400	WD40	1917 → 1956	WD domain, G-beta repeat	Repeat
  PF00400	WD40	51 → 91	WD domain, G-beta repeat	Repeat
  PF00400	WD40	96 → 136	WD domain, G-beta repeat	Repeat
  PF00400	WD40	715 → 757	WD domain, G-beta repeat	Repeat
  PF00400	WD40	1229 → 1267	WD domain, G-beta repeat	Repeat
  PF00400	WD40	988 → 1026	WD domain, G-beta repeat	Repeat
  PF03451	HELP	652 → 715	HELP motif	Family
  PF03451	HELP	1 → 49	HELP motif	Family
  PF03451	HELP	1330 → 1402	HELP motif	Family
  PF12894	ANAPC4_WD40	1734 → 1867	Anaphase-promoting complex subunit 4 WD40 domain	Repeat
  PF12894	ANAPC4_WD40	372 → 462	Anaphase-promoting complex subunit 4 WD40 domain	Repeat

• Sequence:

  MADRTAPRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGH
  NDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQR
  LASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFWTLC
  GNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLNLVRTIQGAHSAGI
  FSMYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGT
  QDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALI
  ARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDG
  SYLAVGSNDGPVDVYAVAQRYKKIGECSKSLSFITHIDWSLDSKYLQTNDGAGERLFYRM
  PSGKPLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTEVTDINSVDANYNSSVLVSGDDFG
  LVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRFIPEGVSN
  GMLETAPQEGGADSYSEESDSDLSDVPELDSDIEQEAQINYDRQVYKEDLPQLKQQSKEK
  NHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQ
  RLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDF
  SADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHI
  KFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDILLLKTVK
  AHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLEDNPS
  IRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDK
  TLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHH
  RKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLL
  QVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGIWPAHSDITDVNAAS
  LTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGAD
  TALMIWTREFVGTQESKLVDSEESDTDVEEDGGYDSDVAREKAIDYTTKIYAVSIREMEG
  TKPHQQLKEVSVEERPPVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYRGFDCRNNL
  HYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTT
  PSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVA
  SRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLS
  VAFGANNLTFTGAINGDVYVWKDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTK
  EGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEIIEVGEKNAASNI
  LIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDG
  EMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLT
  QGTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKIT
  WASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKH
  KRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWRCL

• Sequence length: 1958

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (14)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	36543923	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANDROGENETIC ALOPECIA	—	GWAS catalog	30573740	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	36543923	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEARING LOSS	—	GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	30487518	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Keratoconus	Uncertain significance	ClinVar Disgenet	—	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
OBESITY	—	GWAS catalog	19553259	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PRIMARY ALDOSTERONISM	—	GWAS catalog	36802911	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	26198764, 35396580	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SENSORINEURAL HEARING LOSS	—	GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE MYOPIA	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	39739889	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	37151119	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	32541925	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (6)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Hypertension	Hypertension	Pubtator	32854392	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypertensive disease	Hypertension	GWASCAT_DG	30487518		★☆☆☆☆ Found in Text Mining only
Keratoconus	Keratoconus	Pubtator	33729517, 39238827	Associate	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	GWASCAT_DG	19553259		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	GWASDB_DG	19553259		★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

Sort by: Blended Diseases Pathways Evidence source

LRP6 2 shared diseasesKeratoconus, Myopia 2 shared evidence sourcesDisgenet (Keratoconus), Disgenet (Myopia) Related via 2 shared diseases including Keratoconus, Myopia — evidence mostly Disgenet. NDP 2 shared diseasesMyopia, Primary aldosteronism 2 shared evidence sourcesDisgenet (Myopia), GWAS catalog (Primary aldosteronism) Related via 2 shared diseases including Myopia, Primary aldosteronism — evidence mostly Disgenet. ZNF469 2 shared diseasesKeratoconus, Myopia 2 shared evidence sourcesDisgenet (Keratoconus), Disgenet (Myopia) Related via 2 shared diseases including Keratoconus, Myopia — evidence mostly Disgenet. NCAPH2 1 shared diseaseMyopia 2 shared evidence sourcesGWAS catalog (Hearing loss), Disgenet (Myopia) Related via 1 shared disease including Myopia — evidence mostly GWAS catalog. LRP1B 2 shared diseasesKeratoconus, Myopia 1 shared evidence sourceDisgenet (Myopia) Related via 2 shared diseases including Keratoconus, Myopia — evidence mostly Disgenet.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
LRP6	2	["Keratoconus","Myopia"]	0	[]	2	["Disgenet (Keratoconus)","Disgenet (Myopia)"]
NDP	2	["Myopia","Primary aldosteronism"]	0	[]	2	["Disgenet (Myopia)","GWAS catalog (Primary aldosteronism)"]
ZNF469	2	["Keratoconus","Myopia"]	0	[]	2	["Disgenet (Keratoconus)","Disgenet (Myopia)"]
NCAPH2	1	["Myopia"]	0	[]	2	["GWAS catalog (Hearing loss)","Disgenet (Myopia)"]
LRP1B	2	["Keratoconus","Myopia"]	0	[]	1	["Disgenet (Myopia)"]

Diseases Linked via Similar Genes

Exudative vitreoretinopathy Linked via 2 of 5 related genesLRP6, NDP Corneal disease Linked via 2 of 5 related genesZNF469, LRP1B Hypohidrotic ectodermal dysplasia Linked via 1 of 5 related genesLRP6 Coronary artery disease Linked via 1 of 5 related genesLRP6 Tooth agenesis Linked via 1 of 5 related genesLRP6

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Exudative vitreoretinopathy	2	["LRP6","NDP"]
Corneal disease	2	["ZNF469","LRP1B"]
Hypohidrotic ectodermal dysplasia	1	["LRP6"]
Coronary artery disease	1	["LRP6"]
Tooth agenesis	1	["LRP6"]