EMC3 (ER membrane protein complex subunit 3)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55831
• Gene name: ER membrane protein complex subunit 3
• Gene symbol: EMC3
• Synonyms (NCBI Gene): POB, TMEM111
• Chromosome: 3
• Chromosome location: 3p25.3

miRNA Show/Hide all (155)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019969	hsa-miR-375	Microarray	20215506
MIRT029894	hsa-miR-26b-5p	Microarray	19088304
MIRT675722	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT675721	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT675720	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT675719	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT675718	hsa-miR-4269	HITS-CLIP	23824327
MIRT675717	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT675716	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT675714	hsa-miR-4673	HITS-CLIP	23824327
MIRT675715	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT675713	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT675712	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT675711	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT675710	hsa-miR-4284	HITS-CLIP	23824327
MIRT675709	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT675708	hsa-miR-7977	HITS-CLIP	23824327
MIRT675707	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT675706	hsa-miR-548s	HITS-CLIP	23824327
MIRT675705	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT675704	hsa-miR-588	HITS-CLIP	23824327
MIRT675703	hsa-miR-4435	HITS-CLIP	23824327
MIRT675702	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT675701	hsa-miR-1972	HITS-CLIP	23824327
MIRT675700	hsa-miR-6895-5p	HITS-CLIP	23824327
MIRT658702	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT658701	hsa-miR-8063	HITS-CLIP	23824327
MIRT658700	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT658699	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT658698	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT658697	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT658696	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT658695	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT658694	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT658693	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT658692	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT658691	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT658690	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612182	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT612181	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT612180	hsa-miR-1245b-3p	HITS-CLIP	23824327
MIRT612179	hsa-miR-4534	HITS-CLIP	23824327
MIRT612178	hsa-miR-8082	HITS-CLIP	23824327
MIRT612177	hsa-miR-4653-3p	HITS-CLIP	23824327
MIRT612176	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612175	hsa-miR-5100	HITS-CLIP	23824327
MIRT612174	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT612173	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612172	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612171	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612170	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612169	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT612182	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT612180	hsa-miR-1245b-3p	HITS-CLIP	23824327
MIRT612179	hsa-miR-4534	HITS-CLIP	23824327
MIRT612178	hsa-miR-8082	HITS-CLIP	23824327
MIRT612176	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612175	hsa-miR-5100	HITS-CLIP	23824327
MIRT612174	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT612173	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612172	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612171	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612170	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612169	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT612182	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT612181	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT612180	hsa-miR-1245b-3p	HITS-CLIP	23824327
MIRT612179	hsa-miR-4534	HITS-CLIP	23824327
MIRT612178	hsa-miR-8082	HITS-CLIP	23824327
MIRT612177	hsa-miR-4653-3p	HITS-CLIP	23824327
MIRT612176	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612175	hsa-miR-5100	HITS-CLIP	23824327
MIRT612174	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT612173	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612172	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612171	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612170	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612169	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT675710	hsa-miR-4284	PAR-CLIP	27292025
MIRT675722	hsa-miR-5582-5p	HITS-CLIP	23824327
MIRT675721	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT675720	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT675719	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT675718	hsa-miR-4269	HITS-CLIP	23824327
MIRT675717	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT675716	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT675714	hsa-miR-4673	HITS-CLIP	23824327
MIRT675715	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT675713	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT675712	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT675711	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT675710	hsa-miR-4284	HITS-CLIP	23824327
MIRT675709	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT675708	hsa-miR-7977	HITS-CLIP	23824327
MIRT675707	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT675706	hsa-miR-548s	HITS-CLIP	23824327
MIRT675705	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT675704	hsa-miR-588	HITS-CLIP	23824327
MIRT675703	hsa-miR-4435	HITS-CLIP	23824327
MIRT675702	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT675701	hsa-miR-1972	HITS-CLIP	23824327
MIRT675700	hsa-miR-6895-5p	HITS-CLIP	23824327
MIRT658702	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT658701	hsa-miR-8063	HITS-CLIP	23824327
MIRT658700	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT658699	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT658698	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT658697	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT658696	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT658695	hsa-miR-619-5p	HITS-CLIP	23824327
MIRT658694	hsa-miR-6506-5p	HITS-CLIP	23824327
MIRT658693	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT658692	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT658691	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT658690	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612182	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT612181	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT612180	hsa-miR-1245b-3p	HITS-CLIP	23824327
MIRT612179	hsa-miR-4534	HITS-CLIP	23824327
MIRT612178	hsa-miR-8082	HITS-CLIP	23824327
MIRT612177	hsa-miR-4653-3p	HITS-CLIP	23824327
MIRT612176	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612175	hsa-miR-5100	HITS-CLIP	23824327
MIRT612174	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT612173	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612172	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612171	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612170	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612169	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT612182	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT612180	hsa-miR-1245b-3p	HITS-CLIP	23824327
MIRT612179	hsa-miR-4534	HITS-CLIP	23824327
MIRT612178	hsa-miR-8082	HITS-CLIP	23824327
MIRT612176	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612175	hsa-miR-5100	HITS-CLIP	23824327
MIRT612174	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT612173	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612172	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612171	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612170	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612169	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT612182	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT612181	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT612180	hsa-miR-1245b-3p	HITS-CLIP	23824327
MIRT612179	hsa-miR-4534	HITS-CLIP	23824327
MIRT612178	hsa-miR-8082	HITS-CLIP	23824327
MIRT612177	hsa-miR-4653-3p	HITS-CLIP	23824327
MIRT612176	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612175	hsa-miR-5100	HITS-CLIP	23824327
MIRT612174	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT612173	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT612172	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT612171	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT612170	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612169	hsa-miR-1277-5p	HITS-CLIP	23824327

Gene ontology (GO) Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	22119785, 26496610, 32296183, 32439656, 33961781, 35271311
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	32439656
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	NAS	29242231
GO:0016020	Component	Membrane	IDA	22119785
GO:0016020	Component	Membrane	IEA
GO:0032977	Function	Membrane insertase activity	IMP	29809151, 30415835
GO:0045050	Process	Protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IDA	29242231
GO:0045050	Process	Protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IMP	29809151, 30415835
GO:0071816	Process	Tail-anchored membrane protein insertion into ER membrane	IDA	29242231
GO:0072546	Component	EMC complex	IBA
GO:0072546	Component	EMC complex	IDA	22119785
GO:0072546	Component	EMC complex	IPI	32439656
GO:0072546	Component	EMC complex	ISS

Other IDs

• MIM: 620273
• HGNC: 23999
• e!Ensembl: ENSG00000125037

Protein

• UniProt ID: Q9P0I2
• Protein name: ER membrane protein complex subunit 3 (Transmembrane protein 111)
• Protein function: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed
• PDB: 6WW7 , 6Z3W , 7ADO , 7ADP , 8EOI , 8J0N , 8J0O , 8S9S , 9C7V
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01956	EMC3_TMCO1	5 → 191	Integral membrane protein EMC3/TMCO1-like	Family

• Sequence:

  MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRV
  LRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPMTDPTMLTDMMKGNVTNVLP
  MILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLR
  SIYSLILGQDNAADQSRMMQEQMTGAAMAMPADTNKAFKTEWEALELTDHQWALDDVEEE
  LMAKDLHFEGMFKKELQTSIF

• Sequence length: 261

Related Genes

No strongly related genes found yet for EMC3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to EMC3.