EIF5B (eukaryotic translation initiation factor 5B)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 9669
• Gene name: Eukaryotic translation initiation factor 5B
• Gene symbol: EIF5B
• Synonyms (NCBI Gene): IF2
• Chromosome: 2
• Chromosome location: 2q11.2
• Summary: Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors ar

miRNA Show/Hide all (186)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031635	hsa-miR-16-5p	Proteomics	18668040
MIRT046523	hsa-miR-15b-5p	CLASH	23622248
MIRT042049	hsa-miR-484	CLASH	23622248
MIRT959566	hsa-miR-144	CLIP-seq
MIRT959567	hsa-miR-145	CLIP-seq
MIRT959568	hsa-miR-186	CLIP-seq
MIRT959569	hsa-miR-2110	CLIP-seq
MIRT959570	hsa-miR-218	CLIP-seq
MIRT959571	hsa-miR-25	CLIP-seq
MIRT959572	hsa-miR-296-3p	CLIP-seq
MIRT959573	hsa-miR-3074-3p	CLIP-seq
MIRT959574	hsa-miR-3074-5p	CLIP-seq
MIRT959575	hsa-miR-3123	CLIP-seq
MIRT959576	hsa-miR-3133	CLIP-seq
MIRT959577	hsa-miR-3140-3p	CLIP-seq
MIRT959578	hsa-miR-3145-5p	CLIP-seq
MIRT959579	hsa-miR-3150a-3p	CLIP-seq
MIRT959580	hsa-miR-3154	CLIP-seq
MIRT959581	hsa-miR-32	CLIP-seq
MIRT959582	hsa-miR-3202	CLIP-seq
MIRT959583	hsa-miR-330-3p	CLIP-seq
MIRT959584	hsa-miR-33a	CLIP-seq
MIRT959585	hsa-miR-33b	CLIP-seq
MIRT959586	hsa-miR-3607-5p	CLIP-seq
MIRT959587	hsa-miR-361-5p	CLIP-seq
MIRT959588	hsa-miR-363	CLIP-seq
MIRT959589	hsa-miR-367	CLIP-seq
MIRT959590	hsa-miR-370	CLIP-seq
MIRT959591	hsa-miR-377	CLIP-seq
MIRT959592	hsa-miR-3925-3p	CLIP-seq
MIRT959593	hsa-miR-3925-5p	CLIP-seq
MIRT959594	hsa-miR-4271	CLIP-seq
MIRT959595	hsa-miR-4480	CLIP-seq
MIRT959596	hsa-miR-4636	CLIP-seq
MIRT959597	hsa-miR-4699-3p	CLIP-seq
MIRT959598	hsa-miR-4716-5p	CLIP-seq
MIRT959599	hsa-miR-4725-3p	CLIP-seq
MIRT959600	hsa-miR-4731-3p	CLIP-seq
MIRT959601	hsa-miR-4735-5p	CLIP-seq
MIRT959602	hsa-miR-4744	CLIP-seq
MIRT959603	hsa-miR-4747-5p	CLIP-seq
MIRT959604	hsa-miR-4775	CLIP-seq
MIRT959605	hsa-miR-4801	CLIP-seq
MIRT959606	hsa-miR-508-5p	CLIP-seq
MIRT959607	hsa-miR-590-3p	CLIP-seq
MIRT959608	hsa-miR-636	CLIP-seq
MIRT959609	hsa-miR-646	CLIP-seq
MIRT959610	hsa-miR-92a	CLIP-seq
MIRT959611	hsa-miR-92b	CLIP-seq
MIRT1984232	hsa-miR-1231	CLIP-seq
MIRT1984233	hsa-miR-129-5p	CLIP-seq
MIRT959566	hsa-miR-144	CLIP-seq
MIRT959567	hsa-miR-145	CLIP-seq
MIRT1984234	hsa-miR-199a-5p	CLIP-seq
MIRT1984235	hsa-miR-199b-5p	CLIP-seq
MIRT959569	hsa-miR-2110	CLIP-seq
MIRT959571	hsa-miR-25	CLIP-seq
MIRT959572	hsa-miR-296-3p	CLIP-seq
MIRT959574	hsa-miR-3074-5p	CLIP-seq
MIRT959575	hsa-miR-3123	CLIP-seq
MIRT1984236	hsa-miR-3144-5p	CLIP-seq
MIRT959578	hsa-miR-3145-5p	CLIP-seq
MIRT1984237	hsa-miR-3147	CLIP-seq
MIRT1984238	hsa-miR-3148	CLIP-seq
MIRT959579	hsa-miR-3150a-3p	CLIP-seq
MIRT1984239	hsa-miR-3151	CLIP-seq
MIRT959580	hsa-miR-3154	CLIP-seq
MIRT1984240	hsa-miR-3191	CLIP-seq
MIRT959581	hsa-miR-32	CLIP-seq
MIRT959582	hsa-miR-3202	CLIP-seq
MIRT959583	hsa-miR-330-3p	CLIP-seq
MIRT959584	hsa-miR-33a	CLIP-seq
MIRT959585	hsa-miR-33b	CLIP-seq
MIRT959586	hsa-miR-3607-5p	CLIP-seq
MIRT959588	hsa-miR-363	CLIP-seq
MIRT959589	hsa-miR-367	CLIP-seq
MIRT1984241	hsa-miR-3688-3p	CLIP-seq
MIRT959590	hsa-miR-370	CLIP-seq
MIRT959591	hsa-miR-377	CLIP-seq
MIRT1984242	hsa-miR-3920	CLIP-seq
MIRT959592	hsa-miR-3925-3p	CLIP-seq
MIRT959593	hsa-miR-3925-5p	CLIP-seq
MIRT1984243	hsa-miR-4260	CLIP-seq
MIRT1984244	hsa-miR-4269	CLIP-seq
MIRT959594	hsa-miR-4271	CLIP-seq
MIRT1984245	hsa-miR-4288	CLIP-seq
MIRT1984246	hsa-miR-4302	CLIP-seq
MIRT1984247	hsa-miR-4318	CLIP-seq
MIRT1984248	hsa-miR-4425	CLIP-seq
MIRT1984249	hsa-miR-4447	CLIP-seq
MIRT1984250	hsa-miR-4470	CLIP-seq
MIRT1984251	hsa-miR-4472	CLIP-seq
MIRT959595	hsa-miR-4480	CLIP-seq
MIRT1984252	hsa-miR-450b-3p	CLIP-seq
MIRT1984253	hsa-miR-4652-5p	CLIP-seq
MIRT959597	hsa-miR-4699-3p	CLIP-seq
MIRT959598	hsa-miR-4716-5p	CLIP-seq
MIRT959599	hsa-miR-4725-3p	CLIP-seq
MIRT959603	hsa-miR-4747-5p	CLIP-seq
MIRT1984254	hsa-miR-4789-5p	CLIP-seq
MIRT1984255	hsa-miR-490-5p	CLIP-seq
MIRT1984256	hsa-miR-491-5p	CLIP-seq
MIRT959606	hsa-miR-508-5p	CLIP-seq
MIRT1984257	hsa-miR-570	CLIP-seq
MIRT1984258	hsa-miR-578	CLIP-seq
MIRT1984259	hsa-miR-632	CLIP-seq
MIRT959609	hsa-miR-646	CLIP-seq
MIRT1984260	hsa-miR-769-3p	CLIP-seq
MIRT959610	hsa-miR-92a	CLIP-seq
MIRT959611	hsa-miR-92b	CLIP-seq
MIRT1984232	hsa-miR-1231	CLIP-seq
MIRT1984233	hsa-miR-129-5p	CLIP-seq
MIRT2219350	hsa-miR-142-3p	CLIP-seq
MIRT959566	hsa-miR-144	CLIP-seq
MIRT2219351	hsa-miR-196a	CLIP-seq
MIRT2219352	hsa-miR-196b	CLIP-seq
MIRT959569	hsa-miR-2110	CLIP-seq
MIRT959571	hsa-miR-25	CLIP-seq
MIRT2219353	hsa-miR-300	CLIP-seq
MIRT1984236	hsa-miR-3144-5p	CLIP-seq
MIRT959578	hsa-miR-3145-5p	CLIP-seq
MIRT1984237	hsa-miR-3147	CLIP-seq
MIRT959579	hsa-miR-3150a-3p	CLIP-seq
MIRT1984239	hsa-miR-3151	CLIP-seq
MIRT1984240	hsa-miR-3191	CLIP-seq
MIRT959581	hsa-miR-32	CLIP-seq
MIRT959582	hsa-miR-3202	CLIP-seq
MIRT959584	hsa-miR-33a	CLIP-seq
MIRT959585	hsa-miR-33b	CLIP-seq
MIRT959588	hsa-miR-363	CLIP-seq
MIRT2219354	hsa-miR-3667-3p	CLIP-seq
MIRT959589	hsa-miR-367	CLIP-seq
MIRT2219355	hsa-miR-3682-3p	CLIP-seq
MIRT2219356	hsa-miR-381	CLIP-seq
MIRT1984242	hsa-miR-3920	CLIP-seq
MIRT959592	hsa-miR-3925-3p	CLIP-seq
MIRT1984244	hsa-miR-4269	CLIP-seq
MIRT959594	hsa-miR-4271	CLIP-seq
MIRT1984245	hsa-miR-4288	CLIP-seq
MIRT1984246	hsa-miR-4302	CLIP-seq
MIRT1984247	hsa-miR-4318	CLIP-seq
MIRT1984248	hsa-miR-4425	CLIP-seq
MIRT1984249	hsa-miR-4447	CLIP-seq
MIRT1984251	hsa-miR-4472	CLIP-seq
MIRT1984252	hsa-miR-450b-3p	CLIP-seq
MIRT1984253	hsa-miR-4652-5p	CLIP-seq
MIRT2219357	hsa-miR-4659a-3p	CLIP-seq
MIRT2219358	hsa-miR-4659b-3p	CLIP-seq
MIRT959597	hsa-miR-4699-3p	CLIP-seq
MIRT959599	hsa-miR-4725-3p	CLIP-seq
MIRT959603	hsa-miR-4747-5p	CLIP-seq
MIRT1984254	hsa-miR-4789-5p	CLIP-seq
MIRT1984256	hsa-miR-491-5p	CLIP-seq
MIRT959606	hsa-miR-508-5p	CLIP-seq
MIRT2219359	hsa-miR-587	CLIP-seq
MIRT2219360	hsa-miR-624	CLIP-seq
MIRT1984259	hsa-miR-632	CLIP-seq
MIRT2219361	hsa-miR-648	CLIP-seq
MIRT1984260	hsa-miR-769-3p	CLIP-seq
MIRT959610	hsa-miR-92a	CLIP-seq
MIRT959611	hsa-miR-92b	CLIP-seq
MIRT1984233	hsa-miR-129-5p	CLIP-seq
MIRT1984236	hsa-miR-3144-5p	CLIP-seq
MIRT1984239	hsa-miR-3151	CLIP-seq
MIRT1984240	hsa-miR-3191	CLIP-seq
MIRT1984247	hsa-miR-4318	CLIP-seq
MIRT1984249	hsa-miR-4447	CLIP-seq
MIRT1984251	hsa-miR-4472	CLIP-seq
MIRT1984253	hsa-miR-4652-5p	CLIP-seq
MIRT1984256	hsa-miR-491-5p	CLIP-seq
MIRT959568	hsa-miR-186	CLIP-seq
MIRT959570	hsa-miR-218	CLIP-seq
MIRT959576	hsa-miR-3133	CLIP-seq
MIRT959577	hsa-miR-3140-3p	CLIP-seq
MIRT959583	hsa-miR-330-3p	CLIP-seq
MIRT959591	hsa-miR-377	CLIP-seq
MIRT959600	hsa-miR-4731-3p	CLIP-seq
MIRT959602	hsa-miR-4744	CLIP-seq
MIRT959605	hsa-miR-4801	CLIP-seq
MIRT959608	hsa-miR-636	CLIP-seq
MIRT959609	hsa-miR-646	CLIP-seq
MIRT959570	hsa-miR-218	CLIP-seq
MIRT959577	hsa-miR-3140-3p	CLIP-seq
MIRT959600	hsa-miR-4731-3p	CLIP-seq
MIRT959605	hsa-miR-4801	CLIP-seq
MIRT959608	hsa-miR-636	CLIP-seq

Gene ontology (GO) Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IDA	35732735
GO:0000166	Function	Nucleotide binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003743	Function	Translation initiation factor activity	IBA
GO:0003743	Function	Translation initiation factor activity	IDA	10432305
GO:0003743	Function	Translation initiation factor activity	IEA
GO:0003743	Function	Translation initiation factor activity	NAS	10200264
GO:0003924	Function	GTPase activity	IDA	10659855
GO:0003924	Function	GTPase activity	IEA
GO:0003924	Function	GTPase activity	IMP	35732735
GO:0005515	Function	Protein binding	IPI	12569173, 20195357, 30211544, 32814053, 35732735
GO:0005525	Function	GTP binding	IDA	10659855
GO:0005525	Function	GTP binding	IEA
GO:0005634	Component	Nucleus	IDA	12426392
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	12426392
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006412	Process	Translation	IEA
GO:0006413	Process	Translational initiation	IBA
GO:0006413	Process	Translational initiation	IEA
GO:0006446	Process	Regulation of translational initiation	IDA	10432305
GO:0006446	Process	Regulation of translational initiation	NAS	10200264
GO:0016787	Function	Hydrolase activity	IEA
GO:0042255	Process	Ribosome assembly	IDA	10659855, 35732735
GO:0045202	Component	Synapse	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 606086
• HGNC: 30793
• e!Ensembl: ENSG00000158417

Protein

• UniProt ID: O60841
• Protein name: Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2)
• Protein function: Plays a role in translation initiation (PubMed:10659855, PubMed:35732735). Ribosome-dependent GTPase that promotes the joining of the 60S ribosomal subunit to the pre-initiation complex to form the 80S initiation complex with the initiator methi
• PDB: 7TQL , 8PJ3 , 8PJ4 , 8PJ5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00009	GTP_EFTU	629 → 844	Elongation factor Tu GTP binding domain	Domain
  PF03144	GTP_EFTU_D2	870 → 948	Elongation factor Tu domain 2	Domain
  PF11987	IF-2	963 → 1070	Translation-initiation factor 2	Domain

• Sequence:

  MGKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILK
  ELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKD
  SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRI
  NSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERER
  KKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAE
  TPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR
  EEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAE
  ATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGV
  PEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEE
  EEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRT
  KEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGE
  AGGITQQIGATNVPLEAINEQTKMIKNFDRENVRIPGMLIIDTPGHESFSNLRNRGSSLC
  DIAILVVDIMHGLEPQTIESINLLKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQK
  KNTKDEFEERAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVE
  LTQTMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGVEGPIVTQ
  IRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLLVAYKEDEIPVLK
  DELIHELKQTLNAIKLEEKGVYVQASTLGSLEALLEFLKTSEVPYAGINIGPVHKKDVMK
  ASVMLEHDPQYAVILAFDVRIERDAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQK
  QEEFKHIAVFPCKIKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTS
  IEINHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDALKDWFRD
  EMQKSDWQLIVELKKVFEII

• Sequence length: 1220

Pathways

Reactome Pathway:

GTP hydrolysis and joining of the 60S ribosomal subunit

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (8)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Cervical cancer	Benign; Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign; Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign; Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign; Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Benign; Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental delay	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign; Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (11)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma	Adenocarcinoma	BEFREE	28649990		★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	BEFREE	31671279		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	30225603		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	29687002, 30670698	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	30670698		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	30670698, 31671279		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	27694689		★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASDB_DG	22472876		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	27773872		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31671279		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	28649990	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for EIF5B.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to EIF5B.