EIF1AY (eukaryotic translation initiation factor 1A Y-linked)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 9086
• Gene name: Eukaryotic translation initiation factor 1A Y-linked
• Gene symbol: EIF1AY
• Synonyms (NCBI Gene): eIF-4C
• Chromosome: Y
• Chromosome location: Yq11.223
• Summary: This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits.

miRNA Show/Hide all (29)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029071	hsa-miR-26b-5p	Microarray	19088304
MIRT956306	hsa-miR-3160-5p	CLIP-seq
MIRT956307	hsa-miR-329	CLIP-seq
MIRT956308	hsa-miR-362-3p	CLIP-seq
MIRT956309	hsa-miR-3920	CLIP-seq
MIRT956310	hsa-miR-3941	CLIP-seq
MIRT956311	hsa-miR-3942-3p	CLIP-seq
MIRT956312	hsa-miR-4762-3p	CLIP-seq
MIRT956313	hsa-miR-4799-5p	CLIP-seq
MIRT956314	hsa-miR-494	CLIP-seq
MIRT956315	hsa-miR-548u	CLIP-seq
MIRT956316	hsa-miR-570	CLIP-seq
MIRT956317	hsa-miR-603	CLIP-seq
MIRT1983208	hsa-miR-4795-3p	CLIP-seq
MIRT2218455	hsa-miR-3120-5p	CLIP-seq
MIRT2218456	hsa-miR-338-3p	CLIP-seq
MIRT2218457	hsa-miR-361-5p	CLIP-seq
MIRT2218458	hsa-miR-3671	CLIP-seq
MIRT2218459	hsa-miR-3682-3p	CLIP-seq
MIRT2218460	hsa-miR-4652-3p	CLIP-seq
MIRT956313	hsa-miR-4799-5p	CLIP-seq
MIRT2218461	hsa-miR-563	CLIP-seq
MIRT2218462	hsa-miR-607	CLIP-seq
MIRT2387311	hsa-miR-1236	CLIP-seq
MIRT2218459	hsa-miR-3682-3p	CLIP-seq
MIRT2387312	hsa-miR-4753-3p	CLIP-seq
MIRT2387313	hsa-miR-4768-5p	CLIP-seq
MIRT2387314	hsa-miR-4778-3p	CLIP-seq
MIRT2218461	hsa-miR-563	CLIP-seq

Gene ontology (GO) Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003743	Function	Translation initiation factor activity	IBA
GO:0003743	Function	Translation initiation factor activity	IEA
GO:0005515	Function	Protein binding	IPI	16713569, 25910212, 32814053
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0006412	Process	Translation	IEA
GO:0006413	Process	Translational initiation	IBA
GO:0006413	Process	Translational initiation	IEA

Other IDs

• MIM: 400014
• HGNC: 3252
• e!Ensembl: ENSG00000198692

Protein

• UniProt ID: O14602
• Protein name: Eukaryotic translation initiation factor 1A, Y-chromosomal (eIF-1A Y isoform) (eIF1A Y isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C)
• Protein function: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with E
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01176	eIF-1a	32 → 94	Translation initiation factor 1A / IF-1	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous.
• Sequence:

  MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEALCFDGVKRLCH
  IRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDT
  FGPGDDDEIQFDDIGDDDEDIDDI

• Sequence length: 144

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
AUTISM	—	GWAS catalog	32996047	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (7)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	37833700	Associate	★☆☆☆☆ Found in Text Mining only
Azoospermia	Azoospermia	BEFREE	16936303		★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Dilated	Dilated cardiomyopathy	Pubtator	12057908	Associate	★☆☆☆☆ Found in Text Mining only
Coronary Disease	Coronary artery disease	Pubtator	36688193	Associate	★☆☆☆☆ Found in Text Mining only
Heart Failure	Heart failure	Pubtator	35346191	Associate	★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune System Diseases	BEFREE	24741625		★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	32788627	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for EIF1AY.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to EIF1AY.