EEF1G (eukaryotic translation elongation factor 1 gamma)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 1937
• Gene name: Eukaryotic translation elongation factor 1 gamma
• Gene symbol: EEF1G
• Synonyms (NCBI Gene): EF1G, GIG35
• Chromosome: 11
• Chromosome location: 11q12.3
• Summary: This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the

miRNA Show/Hide all (126)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031395	hsa-miR-16-5p	Proteomics	18668040
MIRT440748	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440748	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT953125	hsa-miR-125a-5p	CLIP-seq
MIRT953126	hsa-miR-125b	CLIP-seq
MIRT953127	hsa-miR-31	CLIP-seq
MIRT953128	hsa-miR-3179	CLIP-seq
MIRT953129	hsa-miR-3665	CLIP-seq
MIRT953130	hsa-miR-4287	CLIP-seq
MIRT953131	hsa-miR-4319	CLIP-seq
MIRT953132	hsa-miR-4328	CLIP-seq
MIRT953133	hsa-miR-4436b-3p	CLIP-seq
MIRT953134	hsa-miR-4469	CLIP-seq
MIRT953135	hsa-miR-4514	CLIP-seq
MIRT953136	hsa-miR-4685-3p	CLIP-seq
MIRT953137	hsa-miR-4692	CLIP-seq
MIRT953138	hsa-miR-4732-3p	CLIP-seq
MIRT953139	hsa-miR-4736	CLIP-seq
MIRT953140	hsa-miR-670	CLIP-seq
MIRT953141	hsa-miR-764	CLIP-seq
MIRT953125	hsa-miR-125a-5p	CLIP-seq
MIRT953126	hsa-miR-125b	CLIP-seq
MIRT953127	hsa-miR-31	CLIP-seq
MIRT953128	hsa-miR-3179	CLIP-seq
MIRT953129	hsa-miR-3665	CLIP-seq
MIRT953130	hsa-miR-4287	CLIP-seq
MIRT953131	hsa-miR-4319	CLIP-seq
MIRT953132	hsa-miR-4328	CLIP-seq
MIRT953133	hsa-miR-4436b-3p	CLIP-seq
MIRT953134	hsa-miR-4469	CLIP-seq
MIRT953135	hsa-miR-4514	CLIP-seq
MIRT953136	hsa-miR-4685-3p	CLIP-seq
MIRT953137	hsa-miR-4692	CLIP-seq
MIRT953138	hsa-miR-4732-3p	CLIP-seq
MIRT953139	hsa-miR-4736	CLIP-seq
MIRT953140	hsa-miR-670	CLIP-seq
MIRT953141	hsa-miR-764	CLIP-seq
MIRT953125	hsa-miR-125a-5p	CLIP-seq
MIRT953126	hsa-miR-125b	CLIP-seq
MIRT953127	hsa-miR-31	CLIP-seq
MIRT953128	hsa-miR-3179	CLIP-seq
MIRT953129	hsa-miR-3665	CLIP-seq
MIRT953130	hsa-miR-4287	CLIP-seq
MIRT953131	hsa-miR-4319	CLIP-seq
MIRT953133	hsa-miR-4436b-3p	CLIP-seq
MIRT953134	hsa-miR-4469	CLIP-seq
MIRT953135	hsa-miR-4514	CLIP-seq
MIRT953136	hsa-miR-4685-3p	CLIP-seq
MIRT953137	hsa-miR-4692	CLIP-seq
MIRT953138	hsa-miR-4732-3p	CLIP-seq
MIRT953139	hsa-miR-4736	CLIP-seq
MIRT953140	hsa-miR-670	CLIP-seq
MIRT953141	hsa-miR-764	CLIP-seq
MIRT953125	hsa-miR-125a-5p	CLIP-seq
MIRT953126	hsa-miR-125b	CLIP-seq
MIRT953128	hsa-miR-3179	CLIP-seq
MIRT953130	hsa-miR-4287	CLIP-seq
MIRT953131	hsa-miR-4319	CLIP-seq
MIRT953132	hsa-miR-4328	CLIP-seq
MIRT953133	hsa-miR-4436b-3p	CLIP-seq
MIRT953134	hsa-miR-4469	CLIP-seq
MIRT953136	hsa-miR-4685-3p	CLIP-seq
MIRT953138	hsa-miR-4732-3p	CLIP-seq
MIRT953140	hsa-miR-670	CLIP-seq
MIRT953125	hsa-miR-125a-5p	CLIP-seq
MIRT953126	hsa-miR-125b	CLIP-seq
MIRT953128	hsa-miR-3179	CLIP-seq
MIRT953129	hsa-miR-3665	CLIP-seq
MIRT953130	hsa-miR-4287	CLIP-seq
MIRT953131	hsa-miR-4319	CLIP-seq
MIRT953133	hsa-miR-4436b-3p	CLIP-seq
MIRT953134	hsa-miR-4469	CLIP-seq
MIRT953135	hsa-miR-4514	CLIP-seq
MIRT953136	hsa-miR-4685-3p	CLIP-seq
MIRT953137	hsa-miR-4692	CLIP-seq
MIRT953138	hsa-miR-4732-3p	CLIP-seq
MIRT953139	hsa-miR-4736	CLIP-seq
MIRT953140	hsa-miR-670	CLIP-seq
MIRT953141	hsa-miR-764	CLIP-seq
MIRT953125	hsa-miR-125a-5p	CLIP-seq
MIRT953126	hsa-miR-125b	CLIP-seq
MIRT953128	hsa-miR-3179	CLIP-seq
MIRT953129	hsa-miR-3665	CLIP-seq
MIRT953130	hsa-miR-4287	CLIP-seq
MIRT953131	hsa-miR-4319	CLIP-seq
MIRT953133	hsa-miR-4436b-3p	CLIP-seq
MIRT953134	hsa-miR-4469	CLIP-seq
MIRT953135	hsa-miR-4514	CLIP-seq
MIRT953136	hsa-miR-4685-3p	CLIP-seq
MIRT953137	hsa-miR-4692	CLIP-seq
MIRT953138	hsa-miR-4732-3p	CLIP-seq
MIRT953139	hsa-miR-4736	CLIP-seq
MIRT953140	hsa-miR-670	CLIP-seq
MIRT953141	hsa-miR-764	CLIP-seq
MIRT953125	hsa-miR-125a-5p	CLIP-seq
MIRT953126	hsa-miR-125b	CLIP-seq
MIRT953127	hsa-miR-31	CLIP-seq
MIRT953128	hsa-miR-3179	CLIP-seq
MIRT953129	hsa-miR-3665	CLIP-seq
MIRT953130	hsa-miR-4287	CLIP-seq
MIRT953131	hsa-miR-4319	CLIP-seq
MIRT953133	hsa-miR-4436b-3p	CLIP-seq
MIRT953134	hsa-miR-4469	CLIP-seq
MIRT953135	hsa-miR-4514	CLIP-seq
MIRT953136	hsa-miR-4685-3p	CLIP-seq
MIRT953137	hsa-miR-4692	CLIP-seq
MIRT953138	hsa-miR-4732-3p	CLIP-seq
MIRT953139	hsa-miR-4736	CLIP-seq
MIRT953140	hsa-miR-670	CLIP-seq
MIRT953141	hsa-miR-764	CLIP-seq
MIRT953125	hsa-miR-125a-5p	CLIP-seq
MIRT953126	hsa-miR-125b	CLIP-seq
MIRT953127	hsa-miR-31	CLIP-seq
MIRT953128	hsa-miR-3179	CLIP-seq
MIRT953129	hsa-miR-3665	CLIP-seq
MIRT953130	hsa-miR-4287	CLIP-seq
MIRT953131	hsa-miR-4319	CLIP-seq
MIRT953133	hsa-miR-4436b-3p	CLIP-seq
MIRT953134	hsa-miR-4469	CLIP-seq
MIRT953135	hsa-miR-4514	CLIP-seq
MIRT953136	hsa-miR-4685-3p	CLIP-seq
MIRT953137	hsa-miR-4692	CLIP-seq
MIRT953138	hsa-miR-4732-3p	CLIP-seq
MIRT953139	hsa-miR-4736	CLIP-seq
MIRT953140	hsa-miR-670	CLIP-seq
MIRT953141	hsa-miR-764	CLIP-seq

Gene ontology (GO) Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003746	Function	Translation elongation factor activity	IEA
GO:0005515	Function	Protein binding	IPI	10908348, 16169070, 16189514, 17906640, 18157088, 25416956, 27018634, 28514442, 30021884, 32296183, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	8743958, 25468996
GO:0005783	Component	Endoplasmic reticulum	IDA	8743958
GO:0005829	Component	Cytosol	TAS
GO:0006412	Process	Translation	IEA
GO:0006414	Process	Translational elongation	IBA
GO:0006414	Process	Translational elongation	IEA
GO:0009615	Process	Response to virus	IEP	16548883
GO:0016020	Component	Membrane	HDA	19946888
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0070062	Component	Extracellular exosome	HDA	23533145

Other IDs

• MIM: 130593
• HGNC: 3213
• e!Ensembl: ENSG00000254772

Protein

• UniProt ID: P26641
• Protein name: Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma)
• Protein function: Probably plays a role in anchoring the complex to other cellular components.
• PDB: 1PBU , 5DQS , 5JPO
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00043	GST_C	106 → 198	Glutathione S-transferase, C-terminal domain	Domain
  PF00647	EF1G	275 → 381	Elongation factor 1 gamma, conserved domain	Domain
  PF02798	GST_N	2 → 81	Glutathione S-transferase, N-terminal domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in pancreatic tumor tissue and to a lesser extent in normal kidney, intestine, pancreas, stomach, lung, brain, spleen and liver.
• Sequence:

  MAAGTLYTYPENWRAFKALIAAQYSGAQVRVLSAPPHFHFGQTNRTPEFLRKFPAGKVPA
  FEGDDGFCVFESNAIAYYVSNEELRGSTPEAAAQVVQWVSFADSDIVPPASTWVFPTLGI
  MHHNKQATENAKEEVRRILGLLDAYLKTRTFLVGERVTLADITVVCTLLWLYKQVLEPSF
  RQAFPNTNRWFLTCINQPQFRAVLGEVKLCEKMAQFDAKKFAETQPKKDTPRKEKGSREE
  KQKPQAERKEEKKAAAPAPEEEMDECEQALAAEPKAKDPFAHLPKSTFVLDEFKRKYSNE
  DTLSVALPYFWEHFDKDGWSLWYSEYRFPEELTQTFMSCNLITGMFQRLDKLRKNAFASV
  ILFGTNNSSSISGVWVFRGQELAFPLSPDWQVDYESYTWRKLDPGSEETQTLVREYFSWE
  GAFQHVGKAFNQGKIFK

• Sequence length: 437

Pathways

KEGG Pathway:

Legionellosis

Reactome Pathway:

Eukaryotic Translation Elongation

Related Genes

EEF1A1 2 shared pathwaysLegionellosis, Eukaryotic Translation Elongation Related via 2 shared pathways including Legionellosis, Eukaryotic Translation Elongation.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
EEF1A1	0	[]	2	["Legionellosis","Eukaryotic Translation Elongation"]	0	[]

Diseases Linked via Similar Genes

Carcinoma Linked via 1 of 1 related geneEEF1A1 Stomach neoplasms Linked via 1 of 1 related geneEEF1A1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Carcinoma	1	["EEF1A1"]
Stomach neoplasms	1	["EEF1A1"]