EDF1 (endothelial differentiation related factor 1)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 8721
• Gene name: Endothelial differentiation related factor 1
• Gene symbol: EDF1
• Synonyms (NCBI Gene): CFAP280, EDF-1, MBF1
• Chromosome: 9
• Chromosome location: 9q34.3
• Summary: This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general

miRNA Show/Hide all (108)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023925	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT045491	hsa-miR-149-5p	CLASH	23622248
MIRT044209	hsa-miR-99b-5p	CLASH	23622248
MIRT040953	hsa-miR-18a-3p	CLASH	23622248
MIRT040630	hsa-miR-92b-3p	CLASH	23622248
MIRT039892	hsa-miR-615-3p	CLASH	23622248
MIRT038500	hsa-miR-296-3p	CLASH	23622248
MIRT952629	hsa-miR-1587	CLIP-seq
MIRT952630	hsa-miR-214	CLIP-seq
MIRT952631	hsa-miR-2277-3p	CLIP-seq
MIRT952632	hsa-miR-3150a-3p	CLIP-seq
MIRT952633	hsa-miR-3175	CLIP-seq
MIRT952634	hsa-miR-3619-5p	CLIP-seq
MIRT952635	hsa-miR-4492	CLIP-seq
MIRT952636	hsa-miR-4498	CLIP-seq
MIRT952637	hsa-miR-4505	CLIP-seq
MIRT952638	hsa-miR-450b-5p	CLIP-seq
MIRT952639	hsa-miR-4656	CLIP-seq
MIRT952640	hsa-miR-4667-5p	CLIP-seq
MIRT952641	hsa-miR-4675	CLIP-seq
MIRT952642	hsa-miR-4700-5p	CLIP-seq
MIRT952643	hsa-miR-4708-3p	CLIP-seq
MIRT952644	hsa-miR-4728-5p	CLIP-seq
MIRT952645	hsa-miR-4731-5p	CLIP-seq
MIRT952646	hsa-miR-4741	CLIP-seq
MIRT952647	hsa-miR-514	CLIP-seq
MIRT952648	hsa-miR-514b-3p	CLIP-seq
MIRT952649	hsa-miR-761	CLIP-seq
MIRT952650	hsa-miR-762	CLIP-seq
MIRT952651	hsa-miR-939	CLIP-seq
MIRT1982107	hsa-miR-3135b	CLIP-seq
MIRT1982108	hsa-miR-4467	CLIP-seq
MIRT952643	hsa-miR-4708-3p	CLIP-seq
MIRT952629	hsa-miR-1587	CLIP-seq
MIRT952630	hsa-miR-214	CLIP-seq
MIRT952631	hsa-miR-2277-3p	CLIP-seq
MIRT952632	hsa-miR-3150a-3p	CLIP-seq
MIRT952633	hsa-miR-3175	CLIP-seq
MIRT2216945	hsa-miR-320e	CLIP-seq
MIRT952634	hsa-miR-3619-5p	CLIP-seq
MIRT952635	hsa-miR-4492	CLIP-seq
MIRT952636	hsa-miR-4498	CLIP-seq
MIRT952637	hsa-miR-4505	CLIP-seq
MIRT952639	hsa-miR-4656	CLIP-seq
MIRT952640	hsa-miR-4667-5p	CLIP-seq
MIRT952641	hsa-miR-4675	CLIP-seq
MIRT952642	hsa-miR-4700-5p	CLIP-seq
MIRT952644	hsa-miR-4728-5p	CLIP-seq
MIRT952645	hsa-miR-4731-5p	CLIP-seq
MIRT952646	hsa-miR-4741	CLIP-seq
MIRT952649	hsa-miR-761	CLIP-seq
MIRT952650	hsa-miR-762	CLIP-seq
MIRT952651	hsa-miR-939	CLIP-seq
MIRT2521064	hsa-miR-1468	CLIP-seq
MIRT952629	hsa-miR-1587	CLIP-seq
MIRT2521065	hsa-miR-191	CLIP-seq
MIRT952630	hsa-miR-214	CLIP-seq
MIRT952631	hsa-miR-2277-3p	CLIP-seq
MIRT952632	hsa-miR-3150a-3p	CLIP-seq
MIRT2521066	hsa-miR-3150b-3p	CLIP-seq
MIRT952633	hsa-miR-3175	CLIP-seq
MIRT2216945	hsa-miR-320e	CLIP-seq
MIRT952634	hsa-miR-3619-5p	CLIP-seq
MIRT1982108	hsa-miR-4467	CLIP-seq
MIRT952635	hsa-miR-4492	CLIP-seq
MIRT952636	hsa-miR-4498	CLIP-seq
MIRT952637	hsa-miR-4505	CLIP-seq
MIRT952639	hsa-miR-4656	CLIP-seq
MIRT2521067	hsa-miR-4665-3p	CLIP-seq
MIRT952640	hsa-miR-4667-5p	CLIP-seq
MIRT952641	hsa-miR-4675	CLIP-seq
MIRT2521068	hsa-miR-4689	CLIP-seq
MIRT952642	hsa-miR-4700-5p	CLIP-seq
MIRT952644	hsa-miR-4728-5p	CLIP-seq
MIRT952645	hsa-miR-4731-5p	CLIP-seq
MIRT952646	hsa-miR-4741	CLIP-seq
MIRT2521069	hsa-miR-4784	CLIP-seq
MIRT2521070	hsa-miR-711	CLIP-seq
MIRT952649	hsa-miR-761	CLIP-seq
MIRT952650	hsa-miR-762	CLIP-seq
MIRT952651	hsa-miR-939	CLIP-seq
MIRT2521064	hsa-miR-1468	CLIP-seq
MIRT952629	hsa-miR-1587	CLIP-seq
MIRT2521065	hsa-miR-191	CLIP-seq
MIRT952630	hsa-miR-214	CLIP-seq
MIRT952631	hsa-miR-2277-3p	CLIP-seq
MIRT952632	hsa-miR-3150a-3p	CLIP-seq
MIRT2521066	hsa-miR-3150b-3p	CLIP-seq
MIRT952633	hsa-miR-3175	CLIP-seq
MIRT2216945	hsa-miR-320e	CLIP-seq
MIRT952634	hsa-miR-3619-5p	CLIP-seq
MIRT952635	hsa-miR-4492	CLIP-seq
MIRT952636	hsa-miR-4498	CLIP-seq
MIRT952637	hsa-miR-4505	CLIP-seq
MIRT952639	hsa-miR-4656	CLIP-seq
MIRT2521067	hsa-miR-4665-3p	CLIP-seq
MIRT952640	hsa-miR-4667-5p	CLIP-seq
MIRT952641	hsa-miR-4675	CLIP-seq
MIRT2521068	hsa-miR-4689	CLIP-seq
MIRT952642	hsa-miR-4700-5p	CLIP-seq
MIRT952644	hsa-miR-4728-5p	CLIP-seq
MIRT952645	hsa-miR-4731-5p	CLIP-seq
MIRT952646	hsa-miR-4741	CLIP-seq
MIRT2521069	hsa-miR-4784	CLIP-seq
MIRT2521070	hsa-miR-711	CLIP-seq
MIRT952649	hsa-miR-761	CLIP-seq
MIRT952650	hsa-miR-762	CLIP-seq
MIRT952651	hsa-miR-939	CLIP-seq

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001094	Function	TFIID-class transcription factor complex binding	IDA	12040021
GO:0003677	Function	DNA binding	IEA
GO:0003713	Function	Transcription coactivator activity	IMP	10567391, 12040021
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	10567391, 12040021, 21217774, 24008843, 25416956, 31527615, 32814053, 35156780, 36012204
GO:0005516	Function	Calmodulin binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	10567391
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IMP	10567391
GO:0005634	Component	Nucleus	NAS	8164657
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IDA	10567391
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	IMP	10567391
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	TAS	8164657, 12040021
GO:0019216	Process	Regulation of lipid metabolic process	TAS	12040021
GO:0030154	Process	Cell differentiation	IEA
GO:0043388	Process	Positive regulation of DNA binding	IDA	10567391
GO:0045446	Process	Endothelial cell differentiation	TAS	12040021
GO:0045893	Process	Positive regulation of DNA-templated transcription	TAS	8164657

Other IDs

• MIM: 605107
• HGNC: 3164
• e!Ensembl: ENSG00000107223

Protein

• UniProt ID: O60869
• Protein name: Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1)
• Protein function: Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequesterin
• PDB: 1X57 , 6ZVH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01381	HTH_3	81 → 134	Helix-turn-helix	Domain
  PF08523	MBF1	4 → 73	Multiprotein bridging factor 1	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues. {ECO:0000269|PubMed:10567391, ECO:0000269|PubMed:12040021, ECO:000026
• Sequence:

  MAESDWDTVTVLRKKGPTAAQAKSKQAILAAQRRGEDVETSKKWAAGQNKQHSITKNTAK
  LDRETEELHHDRVTLEVGKVIQQGRQSKGLTQKDLATKINEKPQVIADYESGRAIPNNQV
  LGKIERAIGLKLRGKDIGKPIEKGPRAK

• Sequence length: 148

Related Genes

No strongly related genes found yet for EDF1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to EDF1.