Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	1891
Gene name	Enoyl-CoA hydratase 1
Gene symbol	ECH1
Synonyms (NCBI Gene)	HPXEL
Chromosome	19
Chromosome location	19q13.2
Summary	This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encode

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016583	hsa-miR-193b-3p	Proteomics	21512034
MIRT019571	hsa-miR-340-5p	Sequencing	20371350
MIRT029968	hsa-miR-26b-5p	Microarray	19088304
MIRT046350	hsa-miR-23b-3p	CLASH	23622248
MIRT045040	hsa-miR-186-5p	CLASH	23622248
MIRT044420	hsa-miR-320a	CLASH	23622248
MIRT043922	hsa-miR-378a-3p	CLASH	23622248
MIRT951692	hsa-miR-142-5p	CLIP-seq
MIRT951693	hsa-miR-3151	CLIP-seq
MIRT951694	hsa-miR-3153	CLIP-seq
MIRT951695	hsa-miR-340	CLIP-seq
MIRT951696	hsa-miR-342-5p	CLIP-seq
MIRT951697	hsa-miR-4265	CLIP-seq
MIRT951698	hsa-miR-4296	CLIP-seq
MIRT951699	hsa-miR-4322	CLIP-seq
MIRT951700	hsa-miR-4447	CLIP-seq
MIRT951701	hsa-miR-4472	CLIP-seq
MIRT951702	hsa-miR-4646-5p	CLIP-seq
MIRT951703	hsa-miR-4651	CLIP-seq
MIRT951704	hsa-miR-4664-5p	CLIP-seq
MIRT951705	hsa-miR-4668-5p	CLIP-seq
MIRT951706	hsa-miR-4699-5p	CLIP-seq
MIRT951707	hsa-miR-4738-3p	CLIP-seq
MIRT951708	hsa-miR-491-5p	CLIP-seq
MIRT951709	hsa-miR-548g	CLIP-seq
MIRT951710	hsa-miR-561	CLIP-seq
MIRT951711	hsa-miR-608	CLIP-seq
MIRT951697	hsa-miR-4265	CLIP-seq
MIRT951698	hsa-miR-4296	CLIP-seq
MIRT951699	hsa-miR-4322	CLIP-seq
MIRT951694	hsa-miR-3153	CLIP-seq
MIRT2216692	hsa-miR-3910	CLIP-seq
MIRT2216693	hsa-miR-4289	CLIP-seq
MIRT951705	hsa-miR-4668-5p	CLIP-seq
MIRT951707	hsa-miR-4738-3p	CLIP-seq
MIRT2520656	hsa-miR-1255a	CLIP-seq
MIRT2520657	hsa-miR-1255b	CLIP-seq
MIRT2520658	hsa-miR-204	CLIP-seq
MIRT2520659	hsa-miR-211	CLIP-seq
MIRT2520660	hsa-miR-2861	CLIP-seq
MIRT2520661	hsa-miR-3064-5p	CLIP-seq
MIRT2520662	hsa-miR-3197	CLIP-seq
MIRT2520663	hsa-miR-331-3p	CLIP-seq
MIRT2520664	hsa-miR-3652	CLIP-seq
MIRT2520665	hsa-miR-3691-5p	CLIP-seq
MIRT2520666	hsa-miR-3922-5p	CLIP-seq
MIRT2520667	hsa-miR-4287	CLIP-seq
MIRT2520668	hsa-miR-4313	CLIP-seq
MIRT2520669	hsa-miR-4430	CLIP-seq
MIRT2520670	hsa-miR-4505	CLIP-seq
MIRT2520671	hsa-miR-4652-3p	CLIP-seq
MIRT2520672	hsa-miR-4685-3p	CLIP-seq
MIRT2520673	hsa-miR-4731-5p	CLIP-seq
MIRT2520674	hsa-miR-4752	CLIP-seq
MIRT2520675	hsa-miR-661	CLIP-seq
MIRT2520656	hsa-miR-1255a	CLIP-seq
MIRT2520657	hsa-miR-1255b	CLIP-seq
MIRT2520658	hsa-miR-204	CLIP-seq
MIRT2520659	hsa-miR-211	CLIP-seq
MIRT2520660	hsa-miR-2861	CLIP-seq
MIRT2520661	hsa-miR-3064-5p	CLIP-seq
MIRT2520662	hsa-miR-3197	CLIP-seq
MIRT2520663	hsa-miR-331-3p	CLIP-seq
MIRT2520664	hsa-miR-3652	CLIP-seq
MIRT2520665	hsa-miR-3691-5p	CLIP-seq
MIRT2520666	hsa-miR-3922-5p	CLIP-seq
MIRT2520667	hsa-miR-4287	CLIP-seq
MIRT2520668	hsa-miR-4313	CLIP-seq
MIRT2520669	hsa-miR-4430	CLIP-seq
MIRT2520670	hsa-miR-4505	CLIP-seq
MIRT2520671	hsa-miR-4652-3p	CLIP-seq
MIRT2520672	hsa-miR-4685-3p	CLIP-seq
MIRT2520673	hsa-miR-4731-5p	CLIP-seq
MIRT2520674	hsa-miR-4752	CLIP-seq
MIRT2520675	hsa-miR-661	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0005515	Function	Protein binding	IPI	15383276, 21988832, 25416956, 27499296, 31515488, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005777	Component	Peroxisome	IEA
GO:0005777	Component	Peroxisome	NAS	7558027
GO:0005782	Component	Peroxisomal matrix	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006635	Process	Fatty acid beta-oxidation	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016853	Function	Isomerase activity	IEA
GO:0051750	Function	Delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity	IBA
GO:0070062	Component	Extracellular exosome	HDA	20458337

MIM	HGNC	e!Ensembl
600696	3149	ENSG00000104823

Q13011

Protein name

Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-)

Protein function

Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA.

PDB

2VRE , 8SK6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00378	ECH_1	62 → 322	Enoyl-CoA hydratase/isomerase	Domain

Sequence

MAAGIVASRRLRDLLTRRLTGSNYPGLSISLRLTGSSAQEEASGVALGEAPDHSYESLRV
TSAQKHVLHVQLNRPNKRNAMNKVFWREMVECFNKISRDADCRAVVISGAGKMFTAGIDL
MDMASDILQPKGDDVARISWYLRDIITRYQETFNVIERCPKPVIAAVHGGCIGGGVDLVT
ACDIRYCAQDAFFQVKEVDVGLAADVGTLQRLPKVIGNQSLVNELAFTARKMMADEALGS
GLVSRVFPDKEVMLDAALALAAEISSKSPVAVQSTKVNLLYSRDHSVAESLNYVASWNMS
MLQTQDLVKSVQATTENKELKTVTFSKL

Sequence length

328

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Peroxisome	Peroxisomal protein import

ECH1 (enoyl-CoA hydratase 1)

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