ECD (ecdysoneless cell cycle regulator)

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Gene Gene information from NCBI Gene database.
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Entrez ID 11319
Gene name Ecdysoneless cell cycle regulator
Gene symbol ECD
Synonyms (NCBI Gene)
GCR2HSGT1SGT1
Chromosome 10
Chromosome location 10q22.2
miRNA miRNA information provided by mirtarbase database.
3
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miRTarBase ID miRNA Experiments Reference
MIRT025328 hsa-miR-34a-5p Proteomics 21566225
MIRT044103 hsa-miR-361-5p CLASH 23622248
MIRT2520655 hsa-miR-4311 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14 Show/Hide all (14)
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GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 23880345, 23935490, 24656813, 26711270, 28514442, 33961781, 34131137, 35271311, 38270169
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 19919181
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
616464 17029 ENSG00000122882
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95905
Protein name Protein ecdysoneless homolog (Human suppressor of GCR two) (hSGT1)
Protein function Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transa
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07093 SGT1 14 → 597 SGT1 protein Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in muscle and heart. Over-expressed in pancreatic and breast cancers. {ECO:0000269|PubMed:22270930, ECO:0000269|PubMed:22977192}.
Sequence 
MEETMKLATMEDTVEYCLFLIPDESRDSDKHKEILQKYIERIITRFAPMLVPYIWQNQPF
NLKYKPGKGGVPAHMFGVTKFGDNIEDEWFIVYVIKQITKEFPELVARIEDNDGEFLLIE
AADFLPKWLDPENSTNRVFFCHGELCIIPAPRKSGAESWLPTTPPTIPQALNIITAHSEK
ILASESIRAAVNRRIRGYPEKIQASLHRAHCFLPAGIVAVLKQRPRLVAAAVQAFYLRDP
IDLRACRVFKTFLPETRIMTSVTFTKCLYAQLVQQRFVPDRRSGYRLPPPSDPQYRAHEL
GMKLAHGFEILCSKCSPHFSDCKKSLVTASPLWASFLESLKKNDYFKGLIEGSAQYRERL
EMAENYFQLSVDWPESSLAMSPGEEILTLLQTIPFDIEDLKKEAANLPPEDDDQWLDLSP
DQLDQLLQEAVGKKESESVSKEEKEQNYDLTEVSESMKAFISKVSTHKGAELPREPSEAP
ITFDADSFLNYFDKILGPRPNESDSDDLDDEDFECLDSDDDLDFETHEPGEEASLKGTLD
NLKSYMAQMDQELAHTCISKSFTTRNQVEPVSQTTDNNSDEEDSGTGESVMAPVDVDLNL
VSNILESYSSQAGLAGPASNLLQSMGVQLPDNTDHRPTSKPTKN
Sequence length 644
Interactions View interactions

No strongly related genes found yet for ECD.

No additional diseases found yet through genes similar to ECD.