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Gene Gene information from NCBI Gene database.
Entrez ID 85403
Gene name ELL associated factor 1
Gene symbol EAF1
Synonyms (NCBI Gene)
-
Chromosome 3
Chromosome location 3p25.1
miRNA miRNA information provided by mirtarbase database.
696 Show/Hide all (696)
miRTarBase ID miRNA Experiments Reference
MIRT024262 hsa-miR-215-5p Microarray 19074876
MIRT026959 hsa-miR-192-5p Microarray 19074876
MIRT052165 hsa-let-7b-5p CLASH 23622248
MIRT044833 hsa-miR-320a CLASH 23622248
MIRT042498 hsa-miR-423-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
TFPT Unknown 17395368
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17 Show/Hide all (17)
GO ID Ontology Definition Evidence Reference
GO:0003711 Function Transcription elongation factor activity IBA
GO:0003711 Function Transcription elongation factor activity IMP 32087315
GO:0005515 Function Protein binding IPI 21516116, 21729782, 25416956, 27107012, 28514442, 32296183, 32814053, 33961781
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608315 20907 ENSG00000144597
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96JC9
Protein name ELL-associated factor 1
Protein function Acts as a transcriptional transactivator of ELL and ELL2 elongation activities.
PDB 7OKX , 7OKY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09816 EAF 14 → 114 RNA polymerase II transcription elongation factor Domain
Tissue specificity TISSUE SPECIFICITY: Strongly expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine and colon. Poorly expressed in thymus. {ECO:0000269|PubMed:11418481}.
Sequence
MNGTANPLLDREEHCLRLGESFEKRPRASFHTIRYDFKPASIDTSCEGELQVGKGDEVTI
TLPHIPGSTPPMTVFKGNKRPYQKDCVLIINHDTGEYVLEKLSSSIQVKKTRAE
GSSKIQ
ARMEQQPTRPPQTSQPPPPPPPMPFRAPTKPPVGPKTSPLKDNPSPEPQLDDIKRELRAE
VDIIEQMSSSSGSSSSDSESSSGSDDDSSSSGGEDNGPASPPQPSHQQPYNSRPAVANGT
SRPQGSNQLMNTLRNDLQLSESGSDSDD
Sequence length 268
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Formation of RNA Pol II elongation complex
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription Elongation