DUX1 (double homeobox 1)

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Gene Gene information from NCBI Gene database.
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Entrez ID 26584
Gene name Double homeobox 1
Gene symbol DUX1
Synonyms (NCBI Gene)
-
Chromosome 10
Chromosome location -
Summary The human genome contains hundreds of repeats of the 3.3-kb family in regions associated with heterochromatin. The DUX gene family, including DUX1, resides within these 3.3-kb repeated elements (Beckers et al., 2001 [PubMed 11245978]). See DUX4 (MIM 60600
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14 Show/Hide all (14)
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GO ID Ontology Definition Evidence Reference
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 9736770
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IEA
GO:0001228 Function DNA-binding transcription activator activity, RNA polymerase II-specific IDA 9736770
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
611441 3079 HGNC
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O43812
Protein name Double homeobox protein 1
Protein function Probable transcription activator. Binds the P5 DNA element sequence 5'-GATCTGAGTCTAATTGAGAATTACTGTAC-3'.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00046 Homeodomain 95 → 151 Homeodomain Domain
PF00046 Homeodomain 20 → 76 Homeodomain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in rhabdomyosarcoma TE671 cells as well as in several other normal and cancer cells. {ECO:0000269|PubMed:9736770}.
Sequence 
MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEELAQGIDIPE
PRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPG
IAAREELARETGLPESRIQIWFQNRRARHRGQSGRAPTQASIRCNAAPIG
Sequence length 170
Interactions View interactions

No strongly related genes found yet for DUX1.

No additional diseases found yet through genes similar to DUX1.