DUSP19 (dual specificity phosphatase 19)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 142679 |
| Gene name | Dual specificity phosphatase 19 |
| Gene symbol | DUSP19 |
| Synonyms (NCBI Gene) |
DUSP17LMWDSP3SKRP1TS-DSP1
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| Chromosome | 2 |
| Chromosome location | 2q32.1 |
| Summary | Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. |
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miRNA
miRNA information provided by mirtarbase database.
610
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q8WTR2 | ||||||||||
| Protein name | Dual specificity protein phosphatase 19 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase TS-DSP1) (Low molecular weight dual specificity phosphatase 3) (LMW-DSP3) (Protein phosphatase SKRP1) (Stress-activated protein kinase pathway-regulating pho | ||||||||||
| Protein function | Has a dual specificity toward Ser/Thr and Tyr-containing proteins. | ||||||||||
| PDB | 3S4E , 4D3P , 4D3Q , 4D3R | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest. {ECO:0000269|PubMed:12479873}. | ||||||||||
| Sequence |
MYSLNQEIKAFSRNNLRKQCTRVTTLTGKKIIETWKDARIHVVEEVEPSSGGGCGYVQDL |
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| Sequence length | 217 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with DUSP19 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to DUSP19 (see Related Genes above), that are NOT already directly curated for DUSP19 itself -- a lead worth checking, not a confirmed association.
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