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Gene Gene information from NCBI Gene database.
Entrez ID 150290
Gene name Dual specificity phosphatase 18
Gene symbol DUSP18
Synonyms (NCBI Gene)
DSP18DUSP20LMWDSP20
Chromosome 22
Chromosome location 22q12.2
Summary Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues.
miRNA miRNA information provided by mirtarbase database.
544 Show/Hide all (544)
miRTarBase ID miRNA Experiments Reference
MIRT024249 hsa-miR-218-5p Sequencing 20371350
MIRT037689 hsa-miR-744-5p CLASH 23622248
MIRT613648 hsa-miR-8485 HITS-CLIP 23313552
MIRT613647 hsa-miR-329-3p HITS-CLIP 23313552
MIRT613646 hsa-miR-362-3p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22 Show/Hide all (22)
GO ID Ontology Definition Evidence Reference
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004722 Function Protein serine/threonine phosphatase activity IEA
GO:0004725 Function Protein tyrosine phosphatase activity IBA
GO:0004725 Function Protein tyrosine phosphatase activity IDA 12408986
GO:0004725 Function Protein tyrosine phosphatase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611446 18484 ENSG00000167065
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NEJ0
Protein name Dual specificity protein phosphatase 18 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular weight dual specificity phosphatase 20) (LMW-DSP20)
Protein function Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). {ECO:0000269|PubMed:124
PDB 2ESB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00782 DSPc 27 → 157 Dual specificity phosphatase, catalytic domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed with highest levels in liver, brain, ovary and testis. {ECO:0000269|PubMed:12408986, ECO:0000269|PubMed:12591617}.
Sequence
Sequence length 188
Interactions View interactions