DUSP14 (dual specificity phosphatase 14)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 11072
• Gene name: Dual specificity phosphatase 14
• Gene symbol: DUSP14
• Synonyms (NCBI Gene): MKP-L, MKP6
• Chromosome: 17
• Chromosome location: 17q12
• Summary: Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues.

miRNA Show/Hide all (108)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030025	hsa-miR-26b-5p	Microarray	19088304
MIRT031948	hsa-miR-16-5p	Proteomics	18668040
MIRT234263	hsa-miR-922	PAR-CLIP	21572407
MIRT558308	hsa-miR-4528	PAR-CLIP	21572407
MIRT558309	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT558307	hsa-miR-107	PAR-CLIP	21572407
MIRT558305	hsa-miR-7156-3p	PAR-CLIP	21572407
MIRT558306	hsa-miR-1301-3p	PAR-CLIP	21572407
MIRT558303	hsa-miR-5047	PAR-CLIP	21572407
MIRT558304	hsa-miR-6516-5p	PAR-CLIP	21572407
MIRT558302	hsa-miR-450b-5p	PAR-CLIP	21572407
MIRT558301	hsa-miR-507	PAR-CLIP	21572407
MIRT558300	hsa-miR-557	PAR-CLIP	21572407
MIRT558299	hsa-miR-3680-3p	PAR-CLIP	21572407
MIRT234263	hsa-miR-922	PAR-CLIP	21572407
MIRT558308	hsa-miR-4528	PAR-CLIP	21572407
MIRT558309	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT558307	hsa-miR-107	PAR-CLIP	21572407
MIRT558305	hsa-miR-7156-3p	PAR-CLIP	21572407
MIRT558306	hsa-miR-1301-3p	PAR-CLIP	21572407
MIRT558303	hsa-miR-5047	PAR-CLIP	21572407
MIRT558304	hsa-miR-6516-5p	PAR-CLIP	21572407
MIRT558302	hsa-miR-450b-5p	PAR-CLIP	21572407
MIRT558301	hsa-miR-507	PAR-CLIP	21572407
MIRT558300	hsa-miR-557	PAR-CLIP	21572407
MIRT558299	hsa-miR-3680-3p	PAR-CLIP	21572407
MIRT947425	hsa-miR-103a	CLIP-seq
MIRT947426	hsa-miR-1231	CLIP-seq
MIRT947427	hsa-miR-1246	CLIP-seq
MIRT947428	hsa-miR-127-5p	CLIP-seq
MIRT947429	hsa-miR-1301	CLIP-seq
MIRT947430	hsa-miR-185	CLIP-seq
MIRT947431	hsa-miR-2278	CLIP-seq
MIRT947432	hsa-miR-3120-5p	CLIP-seq
MIRT947433	hsa-miR-320e	CLIP-seq
MIRT947434	hsa-miR-3663-5p	CLIP-seq
MIRT947435	hsa-miR-3671	CLIP-seq
MIRT947436	hsa-miR-3910	CLIP-seq
MIRT947437	hsa-miR-4306	CLIP-seq
MIRT947438	hsa-miR-4320	CLIP-seq
MIRT947439	hsa-miR-4477a	CLIP-seq
MIRT947440	hsa-miR-4499	CLIP-seq
MIRT947441	hsa-miR-4644	CLIP-seq
MIRT947442	hsa-miR-4693-3p	CLIP-seq
MIRT947443	hsa-miR-4714-3p	CLIP-seq
MIRT947444	hsa-miR-4717-3p	CLIP-seq
MIRT947445	hsa-miR-4802-3p	CLIP-seq
MIRT947446	hsa-miR-486-3p	CLIP-seq
MIRT947447	hsa-miR-490-5p	CLIP-seq
MIRT947448	hsa-miR-548an	CLIP-seq
MIRT947449	hsa-miR-548g	CLIP-seq
MIRT947450	hsa-miR-607	CLIP-seq
MIRT947451	hsa-miR-661	CLIP-seq
MIRT947425	hsa-miR-103a	CLIP-seq
MIRT947426	hsa-miR-1231	CLIP-seq
MIRT947427	hsa-miR-1246	CLIP-seq
MIRT947428	hsa-miR-127-5p	CLIP-seq
MIRT947429	hsa-miR-1301	CLIP-seq
MIRT947432	hsa-miR-3120-5p	CLIP-seq
MIRT947433	hsa-miR-320e	CLIP-seq
MIRT947434	hsa-miR-3663-5p	CLIP-seq
MIRT947438	hsa-miR-4320	CLIP-seq
MIRT947440	hsa-miR-4499	CLIP-seq
MIRT1980643	hsa-miR-4712-5p	CLIP-seq
MIRT947443	hsa-miR-4714-3p	CLIP-seq
MIRT947444	hsa-miR-4717-3p	CLIP-seq
MIRT947445	hsa-miR-4802-3p	CLIP-seq
MIRT947446	hsa-miR-486-3p	CLIP-seq
MIRT947447	hsa-miR-490-5p	CLIP-seq
MIRT947451	hsa-miR-661	CLIP-seq
MIRT1980644	hsa-miR-770-5p	CLIP-seq
MIRT1980645	hsa-miR-936	CLIP-seq
MIRT947425	hsa-miR-103a	CLIP-seq
MIRT947426	hsa-miR-1231	CLIP-seq
MIRT947427	hsa-miR-1246	CLIP-seq
MIRT2215686	hsa-miR-1253	CLIP-seq
MIRT2215687	hsa-miR-129-5p	CLIP-seq
MIRT947429	hsa-miR-1301	CLIP-seq
MIRT2215688	hsa-miR-18a	CLIP-seq
MIRT2215689	hsa-miR-18b	CLIP-seq
MIRT947431	hsa-miR-2278	CLIP-seq
MIRT947432	hsa-miR-3120-5p	CLIP-seq
MIRT2215690	hsa-miR-3153	CLIP-seq
MIRT2215691	hsa-miR-3157-5p	CLIP-seq
MIRT2215692	hsa-miR-3609	CLIP-seq
MIRT947434	hsa-miR-3663-5p	CLIP-seq
MIRT947438	hsa-miR-4320	CLIP-seq
MIRT2215693	hsa-miR-4691-3p	CLIP-seq
MIRT947442	hsa-miR-4693-3p	CLIP-seq
MIRT947443	hsa-miR-4714-3p	CLIP-seq
MIRT947444	hsa-miR-4717-3p	CLIP-seq
MIRT2215694	hsa-miR-4735-3p	CLIP-seq
MIRT2215695	hsa-miR-4744	CLIP-seq
MIRT2215696	hsa-miR-4761-5p	CLIP-seq
MIRT2215697	hsa-miR-4797-5p	CLIP-seq
MIRT947445	hsa-miR-4802-3p	CLIP-seq
MIRT2215698	hsa-miR-4802-5p	CLIP-seq
MIRT947447	hsa-miR-490-5p	CLIP-seq
MIRT2215699	hsa-miR-520g	CLIP-seq
MIRT2215700	hsa-miR-520h	CLIP-seq
MIRT2215701	hsa-miR-548ah	CLIP-seq
MIRT2215702	hsa-miR-569	CLIP-seq
MIRT2215703	hsa-miR-580	CLIP-seq
MIRT2215704	hsa-miR-589	CLIP-seq
MIRT2215705	hsa-miR-593	CLIP-seq
MIRT2215706	hsa-miR-600	CLIP-seq
MIRT947446	hsa-miR-486-3p	CLIP-seq
MIRT947451	hsa-miR-661	CLIP-seq

Gene ontology (GO) Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004722	Function	Protein serine/threonine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005737	Component	Cytoplasm	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0017017	Function	MAP kinase tyrosine/serine/threonine phosphatase activity	IEA

Other IDs

• MIM: 606618
• HGNC: 17007
• e!Ensembl: ENSG00000276023

Protein

• UniProt ID: O95147
• Protein name: Dual specificity protein phosphatase 14 (EC 3.1.3.16) (EC 3.1.3.48) (MKP-1-like protein tyrosine phosphatase) (MKP-L) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6)
• Protein function: Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases. Plays a negative role in TCR signaling by dephosphorylating MAP3K7 adapter TAB1 leading to its inactivation (PubMed:24403530). {ECO:0000269|PubMed:244035
• PDB: 2WGP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00782	DSPc	34 → 164	Dual specificity phosphatase, catalytic domain	Domain

• Sequence:

  MSSRGHSTLPRTLMAPRMISEGDIGGIAQITSSLFLGRGSVASNRHLLQARGITCIVNAT
  IEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSAT
  LCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGKSTVKMVQTPYGI
  VPDVYEKESRHLMPYWGI

• Sequence length: 198

Related Genes

No strongly related genes found yet for DUSP14.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to DUSP14.