DUSP11 (dual specificity phosphatase 11)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 8446
• Gene name: Dual specificity phosphatase 11
• Gene symbol: DUSP11
• Synonyms (NCBI Gene): PIR1
• Chromosome: 2
• Chromosome location: 2p13.1
• Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regu

miRNA Show/Hide all (53)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049190	hsa-miR-92a-3p	CLASH	23622248
MIRT947350	hsa-miR-217	CLIP-seq
MIRT947351	hsa-miR-3074-5p	CLIP-seq
MIRT947352	hsa-miR-30a	CLIP-seq
MIRT947353	hsa-miR-30b	CLIP-seq
MIRT947354	hsa-miR-30c	CLIP-seq
MIRT947355	hsa-miR-30d	CLIP-seq
MIRT947356	hsa-miR-30e	CLIP-seq
MIRT947357	hsa-miR-3120-3p	CLIP-seq
MIRT947358	hsa-miR-361-5p	CLIP-seq
MIRT947359	hsa-miR-376c	CLIP-seq
MIRT947360	hsa-miR-3908	CLIP-seq
MIRT947361	hsa-miR-4418	CLIP-seq
MIRT947362	hsa-miR-4445	CLIP-seq
MIRT947363	hsa-miR-4662a-3p	CLIP-seq
MIRT947364	hsa-miR-4718	CLIP-seq
MIRT947365	hsa-miR-509-3-5p	CLIP-seq
MIRT947366	hsa-miR-509-5p	CLIP-seq
MIRT947367	hsa-miR-545	CLIP-seq
MIRT947368	hsa-miR-583	CLIP-seq
MIRT947352	hsa-miR-30a	CLIP-seq
MIRT947353	hsa-miR-30b	CLIP-seq
MIRT947354	hsa-miR-30c	CLIP-seq
MIRT947355	hsa-miR-30d	CLIP-seq
MIRT947356	hsa-miR-30e	CLIP-seq
MIRT947357	hsa-miR-3120-3p	CLIP-seq
MIRT947358	hsa-miR-361-5p	CLIP-seq
MIRT947360	hsa-miR-3908	CLIP-seq
MIRT947367	hsa-miR-545	CLIP-seq
MIRT947368	hsa-miR-583	CLIP-seq
MIRT947351	hsa-miR-3074-5p	CLIP-seq
MIRT947352	hsa-miR-30a	CLIP-seq
MIRT947353	hsa-miR-30b	CLIP-seq
MIRT947354	hsa-miR-30c	CLIP-seq
MIRT947355	hsa-miR-30d	CLIP-seq
MIRT947356	hsa-miR-30e	CLIP-seq
MIRT947357	hsa-miR-3120-3p	CLIP-seq
MIRT947358	hsa-miR-361-5p	CLIP-seq
MIRT2215646	hsa-miR-3663-5p	CLIP-seq
MIRT947360	hsa-miR-3908	CLIP-seq
MIRT2215647	hsa-miR-3925-3p	CLIP-seq
MIRT2215648	hsa-miR-3927	CLIP-seq
MIRT2215649	hsa-miR-4267	CLIP-seq
MIRT2215650	hsa-miR-4436a	CLIP-seq
MIRT947362	hsa-miR-4445	CLIP-seq
MIRT2215651	hsa-miR-4464	CLIP-seq
MIRT2215652	hsa-miR-4650-3p	CLIP-seq
MIRT947364	hsa-miR-4718	CLIP-seq
MIRT2215653	hsa-miR-4748	CLIP-seq
MIRT947367	hsa-miR-545	CLIP-seq
MIRT947368	hsa-miR-583	CLIP-seq
MIRT2215654	hsa-miR-665	CLIP-seq
MIRT2215655	hsa-miR-766	CLIP-seq

Gene ontology (GO) Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IDA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IDA	9685386
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	9685386
GO:0004651	Function	Polynucleotide 5'-phosphatase activity	IBA
GO:0004651	Function	Polynucleotide 5'-phosphatase activity	IDA	10347225
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IDA	9685386
GO:0004725	Function	Protein tyrosine phosphatase activity	TAS	9685386
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9685386
GO:0005654	Component	Nucleoplasm	IDA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0006396	Process	RNA processing	TAS	9685386
GO:0006470	Process	Protein dephosphorylation	IDA	9685386
GO:0016607	Component	Nuclear speck	IDA	9685386
GO:0016607	Component	Nuclear speck	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IDA	24447265
GO:0045171	Component	Intercellular bridge	IDA

Other IDs

• MIM: 603092
• HGNC: 3066
• e!Ensembl: ENSG00000144048

Protein

• UniProt ID: O75319
• Protein name: RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Dual specificity protein phosphatase 11) (Phosphatase that interacts with RNA/RNP complex 1)
• Protein function: Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May particip
• PDB: 4JMJ , 4MBB , 4NYH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00782	DSPc	124 → 249	Dual specificity phosphatase, catalytic domain	Domain

• Sequence:

  MRNSETLERGVGGCRVFSCLGSYPGIEGAGLALLADLALGGRLLGTHMSQWHHPRSGWGR
  RRDFSGRSSAKKKGGNHIPERWKDYLPVGQRMPGTRFIAFKVPLQKSFEKKLAPEECFSP
  LDLFNKIREQNEELGLIIDLTYTQRYYKPEDLPETVPYLKIFTVGHQVPDDETIFKFKHA
  VNGFLKENKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGHCLERQ
  NYIEDLQNGPIRKNWNSSVPRSSDFEDSAHLMQPVHNKPVKQGPRYNLHQIQGHSAPRHF
  HTQTQSLQQSVRKFSENPHVYQRHHLPPPGPPGEDYSHRRYSWNVKPNASRAAQDRRRWY
  PYNYSRLSYPACWEWTQ

• Sequence length: 377

Related Genes

No strongly related genes found yet for DUSP11.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to DUSP11.