DUS1L (dihydrouridine synthase 1 like)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 64118
• Gene name: Dihydrouridine synthase 1 like
• Gene symbol: DUS1L
• Synonyms (NCBI Gene): DUS1, PP3111
• Chromosome: 17
• Chromosome location: 17q25.3

miRNA Show/Hide all (89)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025723	hsa-miR-7-5p	Microarray	19073608
MIRT030490	hsa-miR-24-3p	Microarray	19748357
MIRT041289	hsa-miR-193b-3p	CLASH	23622248
MIRT947292	hsa-miR-125a-5p	CLIP-seq
MIRT947293	hsa-miR-125b	CLIP-seq
MIRT947294	hsa-miR-3124-3p	CLIP-seq
MIRT947295	hsa-miR-3692	CLIP-seq
MIRT947296	hsa-miR-3910	CLIP-seq
MIRT947297	hsa-miR-3938	CLIP-seq
MIRT947298	hsa-miR-4319	CLIP-seq
MIRT947299	hsa-miR-4690-5p	CLIP-seq
MIRT947300	hsa-miR-4722-5p	CLIP-seq
MIRT947301	hsa-miR-4732-3p	CLIP-seq
MIRT947302	hsa-miR-4768-3p	CLIP-seq
MIRT947303	hsa-miR-548an	CLIP-seq
MIRT947304	hsa-miR-562	CLIP-seq
MIRT947305	hsa-miR-670	CLIP-seq
MIRT1980598	hsa-miR-1224-5p	CLIP-seq
MIRT1980599	hsa-miR-1268	CLIP-seq
MIRT1980600	hsa-miR-1268b	CLIP-seq
MIRT1980601	hsa-miR-3179	CLIP-seq
MIRT1980602	hsa-miR-4436b-3p	CLIP-seq
MIRT1980603	hsa-miR-4481	CLIP-seq
MIRT1980604	hsa-miR-450b-5p	CLIP-seq
MIRT1980605	hsa-miR-4645-5p	CLIP-seq
MIRT1980606	hsa-miR-4663	CLIP-seq
MIRT1980607	hsa-miR-4673	CLIP-seq
MIRT1980608	hsa-miR-4716-3p	CLIP-seq
MIRT1980609	hsa-miR-4736	CLIP-seq
MIRT1980610	hsa-miR-4745-5p	CLIP-seq
MIRT1980611	hsa-miR-4751	CLIP-seq
MIRT1980612	hsa-miR-507	CLIP-seq
MIRT1980613	hsa-miR-557	CLIP-seq
MIRT1980614	hsa-miR-585	CLIP-seq
MIRT1980615	hsa-miR-759	CLIP-seq
MIRT2215592	hsa-miR-103a	CLIP-seq
MIRT2215593	hsa-miR-107	CLIP-seq
MIRT2215594	hsa-miR-1184	CLIP-seq
MIRT1980598	hsa-miR-1224-5p	CLIP-seq
MIRT947292	hsa-miR-125a-5p	CLIP-seq
MIRT947293	hsa-miR-125b	CLIP-seq
MIRT1980599	hsa-miR-1268	CLIP-seq
MIRT1980600	hsa-miR-1268b	CLIP-seq
MIRT2215595	hsa-miR-187	CLIP-seq
MIRT2215596	hsa-miR-198	CLIP-seq
MIRT2215597	hsa-miR-2861	CLIP-seq
MIRT947294	hsa-miR-3124-3p	CLIP-seq
MIRT2215598	hsa-miR-3155	CLIP-seq
MIRT2215599	hsa-miR-3155b	CLIP-seq
MIRT1980601	hsa-miR-3179	CLIP-seq
MIRT2215600	hsa-miR-3180-5p	CLIP-seq
MIRT2215601	hsa-miR-361-3p	CLIP-seq
MIRT947296	hsa-miR-3910	CLIP-seq
MIRT947297	hsa-miR-3938	CLIP-seq
MIRT2215602	hsa-miR-4286	CLIP-seq
MIRT2215603	hsa-miR-4310	CLIP-seq
MIRT947298	hsa-miR-4319	CLIP-seq
MIRT2215604	hsa-miR-4418	CLIP-seq
MIRT1980602	hsa-miR-4436b-3p	CLIP-seq
MIRT1980603	hsa-miR-4481	CLIP-seq
MIRT1980604	hsa-miR-450b-5p	CLIP-seq
MIRT1980605	hsa-miR-4645-5p	CLIP-seq
MIRT1980606	hsa-miR-4663	CLIP-seq
MIRT1980607	hsa-miR-4673	CLIP-seq
MIRT2215605	hsa-miR-4711-3p	CLIP-seq
MIRT1980608	hsa-miR-4716-3p	CLIP-seq
MIRT947301	hsa-miR-4732-3p	CLIP-seq
MIRT1980609	hsa-miR-4736	CLIP-seq
MIRT1980610	hsa-miR-4745-5p	CLIP-seq
MIRT1980611	hsa-miR-4751	CLIP-seq
MIRT2215606	hsa-miR-484	CLIP-seq
MIRT1980612	hsa-miR-507	CLIP-seq
MIRT2215607	hsa-miR-509-3-5p	CLIP-seq
MIRT2215608	hsa-miR-509-5p	CLIP-seq
MIRT2215609	hsa-miR-511	CLIP-seq
MIRT947303	hsa-miR-548an	CLIP-seq
MIRT1980613	hsa-miR-557	CLIP-seq
MIRT947304	hsa-miR-562	CLIP-seq
MIRT1980614	hsa-miR-585	CLIP-seq
MIRT2215610	hsa-miR-661	CLIP-seq
MIRT947305	hsa-miR-670	CLIP-seq
MIRT1980615	hsa-miR-759	CLIP-seq
MIRT2215592	hsa-miR-103a	CLIP-seq
MIRT2215593	hsa-miR-107	CLIP-seq
MIRT1980604	hsa-miR-450b-5p	CLIP-seq
MIRT1980605	hsa-miR-4645-5p	CLIP-seq
MIRT1980607	hsa-miR-4673	CLIP-seq
MIRT1980612	hsa-miR-507	CLIP-seq
MIRT1980613	hsa-miR-557	CLIP-seq

Gene ontology (GO) Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002943	Process	TRNA dihydrouridine synthesis	IDA	34798057, 39354220
GO:0002943	Process	TRNA dihydrouridine synthesis	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IDA	39354220
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	39354220
GO:0005737	Component	Cytoplasm	IEA
GO:0008033	Process	TRNA processing	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0017150	Function	TRNA dihydrouridine synthase activity	IBA
GO:0017150	Function	TRNA dihydrouridine synthase activity	IEA
GO:0050660	Function	Flavin adenine dinucleotide binding	IEA
GO:0102262	Function	TRNA-dihydrouridine16 synthase activity	IDA	39354220
GO:0102262	Function	TRNA-dihydrouridine16 synthase activity	IEA
GO:0102263	Function	TRNA-dihydrouridine17 synthase activity	IDA	39354220
GO:0102263	Function	TRNA-dihydrouridine17 synthase activity	IEA

Other IDs

• MIM: 621087
• HGNC: 30086
• e!Ensembl: ENSG00000169718

Protein

• UniProt ID: Q6P1R4
• Protein name: tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like (EC 1.3.1.88) (tRNA-dihydrouridine synthase 1-like)
• Protein function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:34798057, PubMed:39354220). Specifically modifies U16 and U17 in cytoplasmic tRNAs (PubMed:39354220). Affects the level of some mature tRNA and
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01207	Dus	20 → 323	Dihydrouridine synthase (Dus)	Family

• Sequence:

  MPKLQGFEFWSRTLRGARHVVAPMVDQSELAWRLLSRRHGAQLCYTPMLHAQVFVRDANY
  RKENLYCEVCPEDRPLIVQFCANDPEVFVQAALLAQDYCDAIDLNLGCPQMIAKRGHYGA
  FLQDEWDLLQRMILLAHEKLSVPVTCKIRVFPEIDKTVRYAQMLEKAGCQLLTVHGRTKE
  QKGPLSGAASWEHIKAVRKAVAIPVFANGNIQCLQDVERCLRDTGVQGVMSAEGNLHNPA
  LFEGRSPAVWELAEEYLDIVREHPCPLSYVRAHLFKLWHHTLQVHQELREELAKVKTLEG
  IAAVSQELKLRCQEEISRQEGAKPTGDLPFHWICQPYIRPGPREGSKEKAGARSKRALEE
  EEGGTEVLSKNKQKKQLRNPHKTFDPSLKPKYAKCDQCGNPKGNRCVFSLCRGCCKKRAS
  KETADCPGHGLLFKTKLEKSLAWKEAQPELQEPQPAAPGTPGGFSEVMGSALA

• Sequence length: 473

Related Genes

No strongly related genes found yet for DUS1L.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to DUS1L.