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Gene Gene information from NCBI Gene database.
Entrez ID 79980
Gene name DSN1 component of MIS12 kinetochore complex
Gene symbol DSN1
Synonyms (NCBI Gene)
C20orf172KNL3MIS13dJ469A13.2hKNL-3
Chromosome 20
Chromosome location 20q11.23
Summary This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in
miRNA miRNA information provided by mirtarbase database.
465 Show/Hide all (465)
miRTarBase ID miRNA Experiments Reference
MIRT016359 hsa-miR-193b-3p Microarray 20304954
MIRT024556 hsa-miR-215-5p Microarray 19074876
MIRT026495 hsa-miR-192-5p Microarray 19074876
MIRT661987 hsa-miR-495-5p HITS-CLIP 23313552
MIRT661986 hsa-miR-382-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26 Show/Hide all (26)
GO ID Ontology Definition Evidence Reference
GO:0000444 Component MIS12/MIND type complex IBA
GO:0000444 Component MIS12/MIND type complex IDA 16585270, 20819937, 27881301
GO:0000444 Component MIS12/MIND type complex IEA
GO:0000444 Component MIS12/MIND type complex NAS 21633384
GO:0000775 Component Chromosome, centromeric region IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609175 16165 ENSG00000149636
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H410
Protein name Kinetochore-associated protein DSN1 homolog
Protein function Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.
PDB 5LSI , 5LSJ , 5LSK , 8PPR , 8Q5H
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08202 MIS13 78 → 354 Mis12-Mtw1 protein family Family
Sequence
Sequence length 356
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Neutrophil degranulation
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation