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Gene Gene information from NCBI Gene database.
Entrez ID 202500
Gene name Dynein regulatory complex subunit 5
Gene symbol DRC5
Synonyms (NCBI Gene)
D6S46FAP155TCTE1
Chromosome 6
Chromosome location 6p21.1
miRNA miRNA information provided by mirtarbase database.
620 Show/Hide all (620)
miRTarBase ID miRNA Experiments Reference
MIRT612387 hsa-miR-342-3p HITS-CLIP 19536157
MIRT612386 hsa-miR-362-3p HITS-CLIP 19536157
MIRT612385 hsa-miR-329-3p HITS-CLIP 19536157
MIRT612384 hsa-miR-8485 HITS-CLIP 19536157
MIRT612382 hsa-miR-1228-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
11 Show/Hide all (11)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 34169321
GO:0005737 Component Cytoplasm IEA
GO:0005856 Component Cytoskeleton IEA
GO:0005929 Component Cilium IEA
GO:0007018 Process Microtubule-based movement IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
186975 11693 ENSG00000146221
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5JU00
Protein name Dynein regulatory complex subunit 5 (T-complex-associated testis-expressed protein 1) (Tcte-1)
Protein function Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the
PDB 8J07
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13516 LRR_6 360 → 383 Leucine Rich repeat Repeat
PF13516 LRR_6 417 → 439 Leucine Rich repeat Repeat
PF13516 LRR_6 305 → 326 Leucine Rich repeat Repeat
PF13516 LRR_6 332 → 355 Leucine Rich repeat Repeat
Sequence
MQDTVTTSALLDPSHSSVSTQDNSSTGGHTSSTSPQLSKPSITPVPAKSRNPHPRANIRR
MRRIIAEDPEWSLAIVPLLTELCIQHIIRNFQKNPILKQMLPEHQQKVLNHLSPDLPLAV
TANLIDSENYWLRCCMHRWPVCHVAHHGGSWKRMFFERHLENLLKHFIPGTTDPAVILDL
LPLCRNYVRRVHVDQFLPPVQLPAQLRPGDQSDSGSEGEMEEPTVDHYQLGDLVAGLSHL
EELDLVYDVKDCGMNFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIII
RSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAH
NTNLISLNLRLNCIEDEGGQALA
HALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTL
TSINLSCNHIGLDGGKQLL
EGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANREAARQR
ALNPSHFMSTITANGPENSVG
Sequence length 501
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
TCTE1-related disorder Likely benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Cleidocranial Dysplasia Cleidocranial Dysplasia BEFREE 7711736
★★★★★
★☆☆☆☆
Found in Text Mining only
Spinocerebellar Ataxia Type 1 Spinocerebellar Ataxia BEFREE 2063871
★★★★★
★☆☆☆☆
Found in Text Mining only