DRC11 (dynein regulatory complex subunit 11)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 79781
• Gene name: Dynein regulatory complex subunit 11
• Gene symbol: DRC11
• Synonyms (NCBI Gene): 4930465P12Rik, IQCA, IQCA1
• Chromosome: 2
• Chromosome location: 2q37.2-q37.3

miRNA Show/Hide all (17)

miRTarBase ID	miRNA	Experiments	Reference
MIRT041209	hsa-miR-193b-3p	CLASH	23622248
MIRT1069471	hsa-miR-23a	CLIP-seq
MIRT1069472	hsa-miR-23b	CLIP-seq
MIRT1069473	hsa-miR-23c	CLIP-seq
MIRT1069474	hsa-miR-513a-3p	CLIP-seq
MIRT1069475	hsa-miR-514	CLIP-seq
MIRT1069476	hsa-miR-514b-3p	CLIP-seq
MIRT2249047	hsa-miR-140-5p	CLIP-seq
MIRT2249048	hsa-miR-3910	CLIP-seq
MIRT2249049	hsa-miR-548an	CLIP-seq
MIRT2552671	hsa-miR-198	CLIP-seq
MIRT2552672	hsa-miR-3153	CLIP-seq
MIRT2249048	hsa-miR-3910	CLIP-seq
MIRT2552673	hsa-miR-4646-5p	CLIP-seq
MIRT2552674	hsa-miR-4668-5p	CLIP-seq
MIRT2249049	hsa-miR-548an	CLIP-seq
MIRT2552675	hsa-miR-661	CLIP-seq

Gene ontology (GO) Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005929	Component	Cilium	IEA
GO:0008568	Function	Microtubule severing ATPase activity	IBA
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0031514	Component	Motile cilium	IEA
GO:0042995	Component	Cell projection	IEA
GO:0051013	Process	Microtubule severing	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q86XH1
• Protein name: Dynein regulatory complex protein 11 (IQ and AAA domain-containing protein 1)
• Protein function: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. {ECO:0000250|UniProtK
• PDB: 8J07
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00004	AAA	571 → 701	ATPase family associated with various cellular activities (AAA)	Domain

• Sequence:

  MSNAMYNKMWHQTQEALGALLDKEPQKMIEPQRNQVFIFQTLATFYVKYVQIFRNLENVY
  DQFVHPQKRILIRKVLDGVMGRILELKNEMVELELTEFHYFDDILQDLKLAPQQLDIPIP
  KYFLKEKLEVIKGREKILAQILADSGIDTSDMKYPVKSIPFDEAVKLIQIAERARQGRLR
  ALFMKQIYLQEYRAKQSKMLGKKVTDTWAAALRIQKVWRRFHQRKETEKLREEEMIFLGM
  NPPPLFNEVSATVIQAEKVDRLRNEVQIKHEEDYREALVTIKNDLKLIEGVDIKENLQDQ
  IRHWFIECRNLTGTFPDYPDVEEGGSAIIFSDKTIQQVIEDIIANQEEEEKNKKKKKKKE
  KQPKKAKKQKKGTKEKNKEEDEKWKMSPSLFLPAMKEGCNAYKEIWMKKDESWNFSQDYD
  PELIKEEKRKELQSEIRIQVDELMRQELKNLKLAVDRERERPVKAGKKKDKKGKKGKKKE
  KKAKKDKDLTADRTIESLYKELVEEGLLIQALKVNLSDYIGEYSYLGTTLRQVSIEPMPS
  LLDVRQLITLYGIWPLGSAAVHEKAPLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLS
  SSNIAGKYPGKNGLQMMLHAVFKVARQLQPSVVWIEDTEKTFYKKVPNAEKMNEPKRLKK
  HLPQILKLLKPDDRILIVGTTRRPFDAELQSFCKVYQKIILVPRPDYASRYVLWKQIIER
  NGGVLTSALNVSCLAKVTDGFTQGHIVEVVKGVLTDQRIRRQIHKPLTAVEFITAITSMN
  PVYKEEEESFKNWYAKTPLGKKRALAITGGSTEKAKDKGKRK

• Sequence length: 822

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Colon adenocarcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

No strongly related genes found yet for DRC11.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to DRC11.